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AB218603

AC 55541, protease-activated receptor 2 (PAR2) agonist

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MW 518.4 Da, Purity >98%. Potent, selective protease-activated receptor 2 (PAR2) agonist that displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. Stimulates cell proliferation, PI hydrolysis and Ca2+ mobilization *in vitro* (pEC50 values are 6.7, 5.9 and 6.6 respectively) and exhibits pronociceptive activity *in vivo*.

Key facts

CAS number

916170-19-9

Purity

>98%

Form

Solid

form

Molecular weight

518.4 Da

Molecular formula

C<sub>2</sub><sub>5</sub>H<sub>2</sub><sub>0</sub>BrN<sub>5</sub>O<sub>3</sub>

PubChem

9589606

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

N-[2-[(2E)-2-[1-(3-bromophenyl)ethylidene]hydrazinyl]-2-oxo-1-(4-oxo-3H-phthalazin-1-yl)ethyl]benzamide

Biological description

Potent, selective protease-activated receptor 2 (PAR2) agonist that displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. Stimulates cell proliferation, PI hydrolysis and Ca2+ mobilization *in vitro* (pEC50 values are 6.7, 5.9 and 6.6 respectively) and exhibits pronociceptive activity *in vivo*.

Canonical smiles

CC(=NNC(=O)C(C1=NNC(=O)C2=CC=CC=C21)NC(=O)C3=CC=CC=C3)C4=CC(=CC=C4)Br

Isomeric smiles

C/C(=N\NC(=O)C(C1=NNC(=O)C2=CC=CC=C21)NC(=O)C3=CC=CC=C3)/C4=CC(=CC=C4)Br

InChi

InChI=1S/C25H20BrN5O3/c1-15(17-10-7-11-18(26)14-17)28-31-25(34)22(27-23(32)16-8-3-2-4-9-16)21-19-12-5-6-13-20(19)24(33)30-29-21/h2-14,22H,1H3,(H,27,32)(H,30,33)(H,31,34)/b28-15+

InChiKey

UCUHFWIFSHROPY-RWPZCVJISA-N

IUPAC Name

N-[2-[(2E)-2-[1-(3-bromophenyl)ethylidene]hydrazinyl]-2-oxo-1-(4-oxo-3H-phthalazin-1-yl)ethyl]benzamide

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 9412 AC-55541. 9412-25 is the same size as the 25 mg size of ab218603.
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|Store under desiccating conditions
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Product protocols

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Biochemicals

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Biochemicals

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Primary Antibodies

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