MW 498.5 Da, Purity >95%. Ac-IEPD-CHO, granzyme B and caspase-8 inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.
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- The Journal of clinical endocrinology and metabolism 93:3179-852008Gonadotropin-releasing hormones I and II induce apoptosis in human granulosa cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesIn-Sun Hong,Anthony P Cheung,Peter C K LeungPubMed 18477660
- The FEBS journal 274:4752-652007Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJohnson Agniswamy,Bin Fang,Irene T WeberPubMed 17697120
- Bioorganic & medicinal chemistry letters 12:2197-2002002Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChristopher A Willoughby,Herbert G Bull,Margarita Garcia-Calvo,Joanne Jiang,Kevin T Chapman,Nancy A ThornberryPubMed 12127536
- The Journal of biological chemistry 277:24631-72002Distinct intracellular signaling in tumor necrosis factor-related apoptosis-inducing ligand- and CD95 ligand-mediated apoptosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJurjen H L Velthuis et. al.PubMed 11980895
- Chemistry & biology 8:357-682001The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJ Rotonda,M Garcia-Calvo,H G Bull,W M Geissler,B M McKeever,C A Willoughby,N A Thornberry,J W BeckerPubMed 11325591
Key facts
- Purity
> 95%
- Molecular weight
498.5 Da
- Molecular formula
C22H34N4O9
- PubChem identifier
16760476
- Nature
Synthetic
Recommended products
MW 498.5 Da, Purity >95%. Ac-IEPD-CHO, granzyme B and caspase-8 inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.
Key facts
- Purity
> 95%
- Molecular weight
498.5 Da
- Molecular formula
C22H34N4O9
- PubChem identifier
16760476
- Nature
Synthetic
- Solubility
Soluble in DMSO.
- Biochemical name
Granzyme B Inhibitor IV
- Canonical SMILES
CC(C)CC(C(=O)NC(CCC(=O)O)C(=O)N1CCCC1C(=O)NC(CC(=O)O)C=O)NC(=O)C
- Isomeric SMILES
CC(C)C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N1CCCC1C(=O)N[C@@H](CC(=O)O)C=O)NC(=O)C
- InChI
InChI=1S/C22H34N4O9/c1-12(2)9-16(23-13(3)28)20(33)25-15(6-7-18(29)30)22(35)26-8-4-5-17(26)21(34)24-14(11-27)10-19(31)32/h11-12,14-17H,4-10H2,1-3H3,(H,23,28)(H,24,34)(H,25,33)(H,29,30)(H,31,32)/t14-,15-,16-,17?/m0/s1
- InChIKey
SVDITSCGEQCTNV-RXMKTKRKSA-N
- IUPAC name
(4S)-4-[[(2S)-2-acetamido-4-methylpentanoyl]amino]-5-[2-[[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-oxopentanoic acid
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
-20°C
- Appropriate long-term storage conditions
-20°C
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
Notes
This product is manufactured by BioVision, an Abcam company and was previously called 1119 Granzyme B Inhibitor Ac-IEPD-CHO. 1119-1 is the same size as the 1 mg size of ab142030.
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1 product image
Chemical Structure - Ac-IEPD-CHO, granzyme B and caspase-8 inhibitor (ab142030)
2D chemical structure image of ab142030, Ac-IEPD-CHO, granzyme B and caspase-8 inhibitor
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