JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB142090

ACC2 Inhibitor, ACC2 (Acetyl-CoA Carboxylase) inhibitor

Be the first to review this product! Submit a review

|

(1 Publication)

MW 403.52 g/mol, Purity >98%. Potent, selective ACC2 (Acetyl-CoA Carboxylase) inhibitor (IC50 values are 28 and 210 nM for hACC2 and hACC1 respectively). Active in vivo and in vitro.
1 Images
Chemical Structure - ACC2 Inhibitor, ACC2 (Acetyl-CoA Carboxylase) inhibitor (AB142090)
  • Chemical Structure

Lab

Chemical Structure - ACC2 Inhibitor, ACC2 (Acetyl-CoA Carboxylase) inhibitor (AB142090)

2D chemical structure image of ab142090, ACC2 Inhibitor, ACC2 (Acetyl-CoA Carboxylase) inhibitor

Key facts

Purity

>98%

Form

Solid

form

Molecular weight

403.52 g/mol

Molecular formula

C<sub>1</sub><sub>9</sub>H<sub>2</sub><sub>1</sub>N<sub>3</sub>O<sub>3</sub>S<sub>2</sub>

Nature

Synthetic

Solubility

Soluble in DMSO

Biological description

Potent, selective ACC2 (Acetyl-CoA Carboxylase) inhibitor (IC50 values are 28 and 210 nM for hACC2 and hACC1 respectively). Active in vivo and in vitro.

Canonical smiles

CC(=O)NC(C)C1CNC(S1)C3CNC(OC2CCC(OC(C)C)CC2)S3

InChi

InChI=1S/C19H21N3O3S2c1-11(2)24-14-5-7-15(8-6-14)25-19-21-10-17(27-19)18-20-9-16(26-18)12(3)22-13(4)23/h5-12H,1-4H3,(H,22,23)

InChiKey

CVAJIWQTUPPAIF-UHFFFAOYSA-N

IUPAC Name

N-(1-(2'-(4-Isopropoxyphenoxy)-2,5'-bithiazol-5-yl)ethyl)acetamide

style
left-column

Complementary Products

Proteins & Peptides

AB7403

Streptavidin (HRP)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Streptavidin (HRP) (AB7403)

  • 5
  • 7
Biochemicals

AB120081

FCCP, mitochondrial oxidative phosphorylation uncoupler

Chemical Structure - FCCP, mitochondrial oxidative phosphorylation uncoupler (AB120081)

  • 4
  • 1
Biochemicals

AB141871

GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor

Functional Studies - GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (AB141871)

  • 5
  • 1
Assay Kits

AB235976

2-NBDG Glucose Uptake Assay Kit

Functional Studies - 2-NBDG Glucose Uptake Assay Kit (AB235976)

  • 0
  • 0
style
left-column

Product details

This product is manufactured by BioVision, an Abcam company and was previously called 1717 ACC2 Inhibitor. 1717-1 is the same size as the 1 mg size of ab142090.
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

|

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

style
left-column
style
left-column
style
left-column

Product protocols

style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical investigation 131: PubMed34255743

2021

WNT6/ACC2-induced storage of triacylglycerols in macrophages is exploited by Mycobacterium tuberculosis.

Applications

Unspecified application

Species

Unspecified reactive species

Julius Brandenburg,Sebastian Marwitz,Simone C Tazoll,Franziska Waldow,Barbara Kalsdorf,Tim Vierbuchen,Thomas Scholzen,Annette Gross,Svenja Goldenbaum,Alexandra Hölscher,Martina Hein,Lara Linnemann,Maja Reimann,Andreas Kispert,Michael Leitges,Jan Rupp,Christoph Lange,Stefan Niemann,Jochen Behrends,Torsten Goldmann,Holger Heine,Ulrich E Schaible,Christoph Hölscher,Dominik Schwudke,Norbert Reiling
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com