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AB143032

Acetylcysteine (N-Acetyl-L-cysteine), ROS inhibitor

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(13 Publications)

MW 163.2 Da, Purity >99%. ROS inhibitor. L-cysteine prodrug. Mucolytic agent. Inhibits viral stimulation by reactive oxygen intermediates. Shows mucolytic, hepatoprotective and antiviral effects in vivo. Orally active.

View Alternative Names

FLJ00280, FLJ00318, FLJ16020, FLJ16733, MGC102720, NR2B1, Nuclear receptor subfamily 2 group B member 1, OTTHUMP00000022510, RXR alpha1, RXRA_HUMAN, Retinoic acid receptor RXR-alpha, Retinoid X nuclear receptor alpha, Retinoid X receptor alpha

1 Images
Chemical Structure - Acetylcysteine (N-Acetyl-L-cysteine), ROS inhibitor (AB143032)
  • Chemical Structure

Lab

Chemical Structure - Acetylcysteine (N-Acetyl-L-cysteine), ROS inhibitor (AB143032)

2D chemical structure image of ab143032, Acetylcysteine (N-Acetyl-L-cysteine), ROS inhibitor

Key facts

CAS number

616-91-1

Purity

>99%

Form

Solid

form

Molecular weight

163.2 Da

Molecular formula

C<sub>5</sub>H<sub>9</sub>NO<sub>3</sub>S

PubChem

12035

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in DMSO to 100 mM

Biochemical name

Acetylcysteine

Biological description

ROS inhibitor. L-cysteine prodrug. Mucolytic agent. Inhibits viral stimulation by reactive oxygen intermediates. Shows mucolytic, hepatoprotective and antiviral effects in vivo. Orally active.

Canonical smiles

CC(=O)NC(CS)C(=O)O

Isomeric smiles

CC(=O)N[C@@H](CS)C(=O)O

InChi

InChI=1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1

InChiKey

PWKSKIMOESPYIA-BYPYZUCNSA-N

IUPAC Name

(2R)-2-acetamido-3-sulfanylpropanoic acid

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Retinoid X Receptor alpha (RXRA) also referred to as NR2B1 is a nuclear receptor with a mass of approximately 55 kDa. RXRA functions as a transcription factor and plays a significant role in regulating gene expression by forming heterodimers with other nuclear receptors. RXRA is expressed in many tissues with notable levels in organs like the liver lungs and kidneys. Its ability to bind DNA sequences known as retinoic acid response elements allows RXRA to regulate diverse physiological processes.
Biological function summary

RXRA serves an important role in metabolic regulation especially in lipid metabolism and glucose homeostasis. It forms heterodimers with partners such as peroxisome proliferator-activated receptors (PPARs) enhancing its capacity to modulate various metabolic pathways. These heterodimers facilitate the transcription of genes that respond to nutritional changes. RXRA also influences immune responses and cell differentiation making it important for maintaining cellular health.

Pathways

RXRA operates within the retinoid signaling and lipid metabolism pathways. Through its interaction with PPARs particularly PPAR-γ and PPAR-α RXRA becomes an integral part of the signaling that controls fatty acid storage and glucose metabolism. These pathways influence cellular function and energy balance impacting the body's overall metabolic status.

RXRA has associations with metabolic diseases such as diabetes and cardiovascular disorders. Dysregulation of RXRA expression or function can disrupt lipid and glucose metabolism leading to insulin resistance and metabolic syndrome. The RXRA-PPAR-γ interaction is essential in these conditions with the pair influencing adipogenesis and inflammatory responses. Understanding and targeting RXRA interactions can provide therapeutic prospects for these metabolic disorders.
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Product protocols

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Publications (13)

Recent publications for all applications. Explore the full list and refine your search

The FEBS journal 292:1726-1742 PubMed39718194

2024

Attenuated NIX in impaired mitophagy contributes to exacerbating cellular senescence in experimental periodontitis under hyperglycemic conditions.

Applications

Unspecified application

Species

Unspecified reactive species

Danni Song,Beibei Chen,Tianfan Cheng,Lijian Jin,Jiangfeng He,Yongming Li,Chongshan Liao

Communications biology 7:1637 PubMed39681694

2024

Toxoplasma gondii infection induces early host cell cycle arrest and DNA damage in primary human host cells by a MYR1-dependent mechanism.

Applications

Unspecified application

Species

Unspecified reactive species

Zahady D Velásquez,Lisbeth Rojas-Baron,Iván Conejeros,Carlos Hermosilla,Anja Taubert

Nature immunology 25:873-885 PubMed38553615

2024

Thioredoxin is a metabolic rheostat controlling regulatory B cells.

Applications

Unspecified application

Species

Unspecified reactive species

Hannah F Bradford,Thomas C R McDonnell,Alexander Stewart,Andrew Skelton,Joseph Ng,Zara Baig,Franca Fraternali,Deborah Dunn-Walters,David A Isenberg,Adnan R Khan,Claudio Mauro,Claudia Mauri

The Journal of pharmacology and experimental therapeutics 388:506-517 PubMed37442618

2024

Differential Efficacy of Small Molecules Dynasore and Mdivi-1 for the Treatment of Dry Eye Epitheliopathy or as a Countermeasure for Nitrogen Mustard Exposure of the Ocular Surface.

Applications

Unspecified application

Species

Unspecified reactive species

Jinhong Pan,Satyabrata Pany,Rafael Martinez-Carrasco,M Elizabeth Fini

Cancers 15: PubMed36831510

2023

Functionalized Hybrid Iron Oxide-Gold Nanoparticles Targeting Membrane Hsp70 Radiosensitize Triple-Negative Breast Cancer Cells by ROS-Mediated Apoptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiyuan Wu,Stefan Stangl,Alicia Hernandez-Schnelzer,Fei Wang,Morteza Hasanzadeh Kafshgari,Ali Bashiri Dezfouli,Gabriele Multhoff

Aging cell 20:e13489 PubMed34704342

2021

Age-dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase B.

Applications

Unspecified application

Species

Unspecified reactive species

Cecilia S Blengini,Alexandra L Nguyen,Mansour Aboelenain,Karen Schindler

International journal of molecular sciences 21: PubMed33291667

2020

AGE-RAGE Axis Stimulates Oxidized LDL Uptake into Macrophages through Cyclin-Dependent Kinase 5-CD36 Pathway via Oxidative Stress Generation.

Applications

Unspecified application

Species

Unspecified reactive species

Hironori Yashima,Michishige Terasaki,Ami Sotokawauchi,Takanori Matsui,Yusaku Mori,Tomomi Saito,Naoya Osaka,Hideki Kushima,Munenori Hiromura,Makoto Ohara,Tomoyasu Fukui,Sho-Ichi Yamagishi

Cancer discovery : PubMed33071215

2020

KEAP1/NFE2L2 mutations predict lung cancer radiation resistance that can be targeted by glutaminase inhibition.

Applications

Unspecified application

Species

Unspecified reactive species

Michael S Binkley,Young-Jun Jeon,Monica Nesselbush,Everett J Moding,Barzin Y Nabet,Diego Almanza,Christian Kunder,Henning Stehr,Christopher H Yoo,Siyeon Rhee,Michael Xiang,Jacob J Chabon,Emily Hamilton,David M Kurtz,Linda Gojenola,Susie Grant Owen,Ryan B Ko,June Ho Shin,Peter G Maxim,Natalie Shaubie Lui,Leah M Backhus,Mark F Berry,Joseph B Shrager,Kavitha J Ramchandran,Sukhmani K Padda,Millie Das,Joel W Neal,Heather A Wakelee,Ash A Alizadeh,Billy W Loo,Maximilian Diehn

FASEB bioAdvances 2:126-144 PubMed32123862

2020

Tumor necrosis factor receptor-2 signaling pathways promote survival of cancer stem-like CD133 cells in clear cell renal carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

John R Bradley,Jun Wang,Simon Pacey,Anne Y Warren,Jordan S Pober,Rafia S Al-Lamki

Neuroscience 416:268-280 PubMed31425734

2019

ROS-Mediated Mitochondrial Dysfunction and ER Stress Contribute to Compression-Induced Neuronal Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Tao Chen,Jie Zhu,Yu-Hai Wang,Chun-Hua Hang
View all publications
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