MW 163.2 Da, Purity >99%. ROS inhibitor. L-cysteine prodrug. Mucolytic agent. Inhibits viral stimulation by reactive oxygen intermediates. Shows mucolytic, hepatoprotective and antiviral effects in vivo. Orally active.
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- The Journal of pharmacology and experimental therapeutics 388:506-5172024Differential Efficacy of Small Molecules Dynasore and Mdivi-1 for the Treatment of Dry Eye Epitheliopathy or as a Countermeasure for Nitrogen Mustard Exposure of the Ocular Surface.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJinhong Pan,Satyabrata Pany,Rafael Martinez-Carrasco,M Elizabeth FiniPubMed 37442618
- Cancers 15:2023Functionalized Hybrid Iron Oxide-Gold Nanoparticles Targeting Membrane Hsp70 Radiosensitize Triple-Negative Breast Cancer Cells by ROS-Mediated Apoptosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhiyuan Wu,Stefan Stangl,Alicia Hernandez-Schnelzer,Fei Wang,Morteza Hasanzadeh Kafshgari,Ali Bashiri Dezfouli,Gabriele MulthoffPubMed 36831510
- Aging cell 20:e134892021Age-dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase B.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCecilia S Blengini,Alexandra L Nguyen,Mansour Aboelenain,Karen SchindlerPubMed 34704342
- International journal of molecular sciences 21:2020AGE-RAGE Axis Stimulates Oxidized LDL Uptake into Macrophages through Cyclin-Dependent Kinase 5-CD36 Pathway via Oxidative Stress Generation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHironori Yashima et. al.PubMed 33291667
- Cancer discovery :2020KEAP1/NFE2L2 mutations predict lung cancer radiation resistance that can be targeted by glutaminase inhibition.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMichael S Binkley et. al.PubMed 33071215
- FASEB bioAdvances 2:126-1442020Tumor necrosis factor receptor-2 signaling pathways promote survival of cancer stem-like CD133 cells in clear cell renal carcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJohn R Bradley,Jun Wang,Simon Pacey,Anne Y Warren,Jordan S Pober,Rafia S Al-LamkiPubMed 32123862
- Neuroscience 416:268-2802019ROS-Mediated Mitochondrial Dysfunction and ER Stress Contribute to Compression-Induced Neuronal Injury.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTao Chen et. al.PubMed 31425734
- Journal of diabetes research 2018:68230582018AGE/RAGE-Induced EMP Release via the NOX-Derived ROS Pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYing-Hua Chen et. al.PubMed 29744367
- Molecular medicine reports 17:6784-67882018COMMD7 activates CXCL10 production by regulating NF-κB and the production of reactive oxygen species.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNan You et. al.PubMed 29532873
- International journal of molecular medicine 41:3448-34562018MCMV triggers ROS/NLRP3-associated inflammasome activation in the inner ear of mice and cultured spiral ganglion neurons, contributing to sensorineural hearing loss.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWei Zhuang et. al.PubMed 29512778
Key facts
- CAS number
616-91-1
- Purity
> 99%
- Form
Solid
- Molecular weight
163.2 Da
- Molecular formula
C5H9NO3S
- PubChem identifier
12035
- Nature
Synthetic
Target data
Alternative names
FLJ00280, FLJ00318, FLJ16020, FLJ16733, MGC102720, NR2B1, Nuclear receptor subfamily 2 group B member 1, OTTHUMP00000022510, RXR alpha1, RXRA_HUMAN, Retinoic acid receptor RXR-alpha, Retinoid X nuclear receptor alpha, Retinoid X receptor alpha
Recommended products
MW 163.2 Da, Purity >99%. ROS inhibitor. L-cysteine prodrug. Mucolytic agent. Inhibits viral stimulation by reactive oxygen intermediates. Shows mucolytic, hepatoprotective and antiviral effects in vivo. Orally active.
Key facts
- CAS number
616-91-1
- Purity
> 99%
- Form
Solid
- Molecular weight
163.2 Da
- Molecular formula
C5H9NO3S
- PubChem identifier
12035
- Nature
Synthetic
- Solubility
1 G IN 5 ML WATER, 4 ML ALC; PRACTICALLY INSOL IN CHLOROFORM & ETHER. Soluble in water, alcohol, hot isopropyl alcohol, methyl acetate, and ethyl acetate.
- Biochemical name
Acetylcysteine
- Biological description
ROS inhibitor. L-cysteine prodrug. Mucolytic agent. Inhibits viral stimulation by reactive oxygen intermediates. Shows mucolytic, hepatoprotective and antiviral effects in vivo. Orally active.
- Canonical SMILES
CC(=O)NC(CS)C(=O)O
- Isomeric SMILES
CC(=O)N[C@@H](CS)C(=O)O
- InChI
InChI=1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1
- InChIKey
PWKSKIMOESPYIA-BYPYZUCNSA-N
- IUPAC name
(2R)-2-acetamido-3-sulfanylpropanoic acid
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
+4°C
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Retinoid X Receptor alpha (RXRA) also referred to as NR2B1 is a nuclear receptor with a mass of approximately 55 kDa. RXRA functions as a transcription factor and plays a significant role in regulating gene expression by forming heterodimers with other nuclear receptors. RXRA is expressed in many tissues with notable levels in organs like the liver lungs and kidneys. Its ability to bind DNA sequences known as retinoic acid response elements allows RXRA to regulate diverse physiological processes.
- Biological function summary
RXRA serves an important role in metabolic regulation especially in lipid metabolism and glucose homeostasis. It forms heterodimers with partners such as peroxisome proliferator-activated receptors (PPARs) enhancing its capacity to modulate various metabolic pathways. These heterodimers facilitate the transcription of genes that respond to nutritional changes. RXRA also influences immune responses and cell differentiation making it important for maintaining cellular health.
- Pathways
RXRA operates within the retinoid signaling and lipid metabolism pathways. Through its interaction with PPARs particularly PPAR-γ and PPAR-α RXRA becomes an integral part of the signaling that controls fatty acid storage and glucose metabolism. These pathways influence cellular function and energy balance impacting the body's overall metabolic status.
- Associated diseases and disorders
RXRA has associations with metabolic diseases such as diabetes and cardiovascular disorders. Dysregulation of RXRA expression or function can disrupt lipid and glucose metabolism leading to insulin resistance and metabolic syndrome. The RXRA-PPAR-γ interaction is essential in these conditions with the pair influencing adipogenesis and inflammatory responses. Understanding and targeting RXRA interactions can provide therapeutic prospects for these metabolic disorders.
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Chemical Structure - Acetylcysteine (N-Acetyl-L-cysteine), ROS inhibitor (ab143032)
2D chemical structure image of ab143032, Acetylcysteine (N-Acetyl-L-cysteine), ROS inhibitor
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