AB141058

Actinomycin D (Dactinomycin), Nucleic acid and protein synthesis inhibitor

Name: Actinomycin D (Dactinomycin), Nucleic acid and protein synthesis inhibitor (CAS 50-76-0) | Abcam
Brand: Abcam Limited
SKU: AB141058
Price: 175 USD
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(18 Publications)

MW 1255.4 Da, Purity >98%. Nucleic acid and protein synthesis inhibitor. Intercalates DNA, stabilizes topoisomerases I and II and inhibits transcription. Antibacterial and antitumor agent. Active in vivo and in vitro.

View Alternative Names

Beta-interferon, Fibroblast interferon, IFB, IFF, IFN-beta, IFNB 1, IFNB_HUMAN, Interferon beta, Interferon beta 1 fibroblast, Interferon beta precursor, MGC96956

1 Images

Chemical Structure - Actinomycin D (Dactinomycin), Nucleic acid and protein synthesis inhibitor (AB141058)

Chemical Structure

Lab

Chemical Structure - Actinomycin D (Dactinomycin), Nucleic acid and protein synthesis inhibitor (AB141058)

2D chemical structure image of ab141058, Actinomycin D (Dactinomycin), Nucleic acid and protein synthesis inhibitor

Key facts

CAS number

50-76-0

Purity

>98%

Form

Solid

form

Source

Streptomyces sp.

Molecular weight

1255.4 Da

Molecular formula

C62H86N12O16

PubChem

2019

Nature

Native

Solubility

Soluble in 20 mg/mL (in DMSO)

Biochemical name

actinomycin D

Biological description

Nucleic acid and protein synthesis inhibitor. Intercalates DNA, stabilizes topoisomerases I and II and inhibits transcription. Antibacterial and antitumor agent. Active in vivo and in vitro.

Canonical smiles

CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C

InChi

InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)

InChiKey

RJURFGZVJUQBHK-UHFFFAOYSA-N

IUPAC Name

2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide

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Product details

This product is hygroscopic. Unused dilute solutions of Actinomycin D are extremely sensitive to light and tend to adsorb to plastic and glass and should be discarded. However, frozen aliquots of concentrated stock solution are stable for at least a month.

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Properties and storage information

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Storage information

It is important to note that this product is reported to be light sensitive|Store in the dark

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Interferon beta also known as IFN-beta or beta interferon is a type I interferon with a mass of approximately 20 kDa. It originates primarily from fibroblasts and plays an essential role in the immune response. This protein targets and binds to specific cell surface receptors initiating various antiviral states within cells. This action assists in slowing down viral replication and spread. IFN-beta's expression increases in response to viral infections making it an important component in the body's first line of defense against pathogens.

Biological function summary

Interferon beta functions as an important mediator of immune functions regulating the activity of natural killer cells and macrophages. It also boosts antigen presentation to T cells. Interferon beta belongs to the larger family of interferons which includes IFN-alpha and IFN-gamma each having distinct effects but working together to mount an effective immune response. Though it does not form part of a complex it plays a critical standalone role in immune signaling pathways.

Pathways

Interferon beta associates strongly with the JAK-STAT signaling pathway. Upon activation it interacts with receptors to phosphorylate STAT proteins mainly STAT1 and STAT2 which then dimerize and translocate to the nucleus to trigger gene expression. Another important pathway is the antiviral response where interferon beta modulates the expression of hundreds of interferon-stimulated genes. These pathways intricately involve other proteins like IFN-alpha and IFN-gamma which work synergistically to establish an effective antiviral environment.

Interferon beta shows significant implications in multiple sclerosis and hepatitis C infection. It is widely used as a therapeutic agent in managing multiple sclerosis by modulating the immune response to reduce inflammation and slow disease progression. Similarly its role in antiviral defense makes it relevant to hepatitis C infection management. In these contexts IFN-alpha and IFN-gamma are also important as they share similar antiviral and immunomodulatory functions that can complement IFN-beta's actions enhancing the treatment's efficacy.

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Product protocols

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Publications (18)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:2078 PubMed40021667

2025

Nuclear retention of unspliced HIV-1 RNA as a reversible post-transcriptional block in latency.

Applications

Unspecified application

Species

Unspecified reactive species

Agnieszka Dorman,Maryam Bendoumou,Aurelija Valaitienė,Jakub Wadas,Haider Ali,Antoine Dutilleul,Paolo Maiuri,Lorena Nestola,Monika Bociaga-Jasik,Gilbert Mchantaf,Coca Necsoi,Stéphane De Wit,Véronique Avettand-Fenoël,Alessandro Marcello,Krzysztof Pyrc,Alexander O Pasternak,Carine Van Lint,Anna Kula-Pacurar

Cell death & disease 16:82 PubMed39924557

2025

The RNA M5C methyltransferase NSUN2 promotes progression of hepatocellular carcinoma by enhancing PKM2-mediated glycolysis.

Applications

Unspecified application

Species

Unspecified reactive species

Qin Qi,Rui Zhong,Yan Huang,Yong Tang,Xiao-Wen Zhang,Chang Liu,Chun-Fang Gao,Lin Zhou,Jian Yu,Lu-Yi Wu

Nature 634:986-994 PubMed39358506

2024

RNA mC oxidation by TET2 regulates chromatin state and leukaemogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Zhongyu Zou,Xiaoyang Dou,Ying Li,Zijie Zhang,Juan Wang,Boyang Gao,Yu Xiao,Yiding Wang,Lijie Zhao,Chenxi Sun,Qinzhe Liu,Xianbin Yu,Hao Wang,Juyeong Hong,Qing Dai,Feng-Chun Yang,Mingjiang Xu,Chuan He

The Tohoku journal of experimental medicine 264:9-19 PubMed38839357

2024

Shenqi Qiangjing Granules Ameliorate Asthenozoospermia in Mice by Regulating Ferroptosis through the METTL3/GPX4 Signaling Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Qiuyu Lu,Jiabao Ma,Luying Wei,Jing Fu,Xiaoxia Li,Kedao Lai,Xin Li,Bingyu Xia,Bin Bin,Aicun Tang

EMBO reports 25:168-197 PubMed38225354

2024

Ribogenesis boosts controlled by HEATR1-MYC interplay promote transition into brain tumour growth.

Applications

Unspecified application

Species

Unspecified reactive species

Laura R Diaz,Jon Gil-Ranedo,Karolina J Jaworek,Nsikan Nsek,Joao Pinheiro Marques,Eleni Costa,David A Hilton,Hubert Bieluczyk,Oliver Warrington,C Oliver Hanemann,Matthias E Futschik,Torsten Bossing,Claudia S Barros

EMBO reports 23:e54859 PubMed35979733

2022

UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Zheng,Yu Cao,Jun Yang,Hui Jiang

Cell death & disease 12:1006 PubMed34707111

2021

c-Myc-activated USP2-AS1 suppresses senescence and promotes tumor progression via stabilization of E2F1 mRNA.

Applications

Unspecified application

Species

Unspecified reactive species

Bingyan Li,Guang Zhang,Zhongyu Wang,Yang Yang,Chenfeng Wang,Debao Fang,Kaiyue Liu,Fang Wang,Yide Mei

Cell death & disease 12:349 PubMed33824282

2021

ZEB1-induced LINC01559 expedites cell proliferation, migration and EMT process in gastric cancer through recruiting IGF2BP2 to stabilize ZEB1 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Huojian Shen,Hongyi Zhu,Yuanwen Chen,Zhiyong Shen,Weiqing Qiu,Changlin Qian,Jie Zhang

Molecular cancer 19:164 PubMed33225938

2020

The circular RNA circ-ERBIN promotes growth and metastasis of colorectal cancer by miR-125a-5p and miR-138-5p/4EBP-1 mediated cap-independent HIF-1α translation.

Applications

Unspecified application

Species

Unspecified reactive species

Liang-Yan Chen,Lian Wang,Yue-Xiang Ren,Zheng Pang,Yao Liu,Xiao-Dong Sun,Jian Tu,Zheng Zhi,Yan Qin,Li-Na Sun,Jian-Ming Li

Genes & diseases 9:494-509 PubMed35224163

2020

Melatonin antagonizes ovarian aging via YTHDF2-MAPK-NF-κB pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Ruigong Zhu,Xian Ji,Xuan Wu,Jiajing Chen,Xuesong Li,Hong Jiang,Haiping Fu,Hui Wang,Zhe Lin,Xin Tang,Shixiu Sun,Qingguo Li,Bingjian Wang,Hongshan Chen

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Actinomycin D (Dactinomycin), Nucleic acid and protein synthesis inhibitor

Chemical Structure - Actinomycin D (Dactinomycin), Nucleic acid and protein synthesis inhibitor (AB141058)

Key facts

CAS number

Purity

Form

Source

Molecular weight

Molecular formula

PubChem

Nature

Solubility

Biochemical name

Biological description

Canonical smiles

InChi

InChiKey

IUPAC Name

Product details

Properties and storage information

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Publications (18)

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Primary Antibodies

Primary Antibodies

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