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AB141089

Actinonin, Matrix metalloprotease (MMP) inhibitor

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MW 385.5 Da, Purity >97%. Potent MMP and peptide deformylase inhibitor. Shows potent activity against peptide deformylase, M, N, leucine, alanyl, dipeptidyl aminopeptidases, enkephalinase A, and meprin α and β. Shows antiproliferative effects. Shows male-specific anti-ischemic effects in vivo. .
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Chemical Structure - Actinonin, Matrix metalloprotease (MMP) inhibitor (AB141089)
  • Chemical Structure

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Chemical Structure - Actinonin, Matrix metalloprotease (MMP) inhibitor (AB141089)

2D chemical structure image of ab141089, Actinonin, Matrix metalloprotease (MMP) inhibitor

Key facts

CAS number

13434-13-4

Purity

>97%

Form

Solid

form

Molecular weight

385.5 Da

Molecular formula

C<sub>1</sub><sub>9</sub>H<sub>3</sub><sub>5</sub>N<sub>3</sub>O<sub>5</sub>

PubChem

443600

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Soluble in ethanol to 50 mM

Biochemical name

Actinonin

Biological description

Potent MMP and peptide deformylase inhibitor. Shows potent activity against peptide deformylase, M, N, leucine, alanyl, dipeptidyl aminopeptidases, enkephalinase A, and meprin α and β. Shows antiproliferative effects. Shows male-specific anti-ischemic effects in vivo.

Canonical smiles

CCCCCC(CC(=O)NO)C(=O)NC(C(C)C)C(=O)N1CCCC1CO

Isomeric smiles

CCCCC[C@H](CC(=O)NO)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1CO

InChi

InChI=1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)/t14-,15+,17+/m1/s1

InChiKey

XJLATMLVMSFZBN-VYDXJSESSA-N

IUPAC Name

(2R)-N'-hydroxy-N-[(2S)-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]-2-pentylbutanediamide

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Complementary Products

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Biochemicals

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Chemical Structure - Thiorphan, Neprilysin/neutral endopeptidase inhibitor (AB141169)

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Biochemicals

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Biochemicals

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD13 also known as aminopeptidase N is a metalloprotease with a molecular mass of approximately 150 kDa. It is expressed on the surface of many cell types including epithelial cells endothelial cells and fibroblasts. CD13 functions mechanically as an actinonin-sensitive enzyme which means it involves in cleaving N-terminal amino acids from peptides and proteins. This activity facilitates the modulation of various cellular processes by adjusting levels of bioactive peptides in the extracellular environment.
Biological function summary

The multifunctional enzyme engages in different roles within the body. It participates in the degradation of signaling peptides which is essential for maintaining cellular environment balance. CD13 is not part of any complex but interacts with other peptides and is involved in antigen processing on certain immune cells. It also influences angiogenesis and cell motility which makes it significant in tissue remodeling and repairing processes.

Pathways

CD13 plays roles in RAS and MAPK signaling pathways. It closely interacts with proteins such as MMP1 and other metalloproteases to orchestrate extracellular matrix remodeling. In these pathways CD13 contributes to processes like cell proliferation and migration by boosting peptide cleavage which links to cellular growth signals. Additionally it works along with stromal cells to influence inflammatory responses.

CD13 has connections to cancer and inflammatory diseases. Its overexpression commonly appears in cancers where it assists tumor cell invasions and metastasis making it a potential target for cancer therapies. In inflammatory disorders CD13 modifies the response by processing peptides that regulate inflammation. Proteins like MMP1 collaborate with CD13 in these diseases further affecting tissue remodeling and inflammation control.
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Product protocols

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