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AB142685

Aeroplysinin (Aeroplysinin-1), antiangiogenic agent

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MW 338.98 Da, Purity >95%. Potent antiangiogenic agent. Inhibits COX-2 expression. Selectivity for endothelial cells. Able to induce apoptosis via capsase activation, chromatin condensation and nuclear fragmentation. Antibiotic and cytotoxic effects (IC50 = 3 μm) and displays a wide-spectrum antitumor activity. Active in vivo. .
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Chemical Structure - Aeroplysinin (Aeroplysinin-1), antiangiogenic agent (AB142685)
  • Chemical Structure

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Chemical Structure - Aeroplysinin (Aeroplysinin-1), antiangiogenic agent (AB142685)

2D chemical structure image of ab142685, Aeroplysinin (Aeroplysinin-1), antiangiogenic agent

Key facts

CAS number

28656-91-9

Purity

>95%

Source

Aplysina aerophoba

Molecular weight

338.98 Da

Molecular formula

C<sub>9</sub>H<sub>9</sub>Br<sub>2</sub>NO<sub>3</sub>

PubChem

100308

Nature

Native

Solubility

Soluble in ethanol to 25 mM

Soluble in DMSO to 25 mM

Biochemical name

Aeroplysinin I

Biological description

Potent antiangiogenic agent. Inhibits COX-2 expression. Selectivity for endothelial cells. Able to induce apoptosis via capsase activation, chromatin condensation and nuclear fragmentation. Antibiotic and cytotoxic effects (IC50 = 3 μm) and displays a wide-spectrum antitumor activity. Active in vivo.

Canonical smiles

COC1=C(C(C(C=C1Br)(CC#N)O)O)Br

Isomeric smiles

COC1=C([C@@H]([C@@](C=C1Br)(CC#N)O)O)Br

InChi

InChI=1S/C9H9Br2NO3/c1-15-7-5(10)4-9(14,2-3-12)8(13)6(7)11/h4,8,13-14H,2H2,1H3/t8-,9-/m0/s1

InChiKey

BGYNLOSBKBOJJD-IUCAKERBSA-N

IUPAC Name

2-[(1S,6R)-3,5-dibromo-1,6-dihydroxy-4-methoxycyclohexa-2,4-dien-1-yl]acetonitrile

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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