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AB141983

AF12198, human type I interleukin receptor antagonist

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AF12198 (CAS No: 185413-30-3)(ab141983). Potent and selective antagonist peptide for human type I interleukin-1 receptor (IL1R1) (IC50 values are 8 nM, > 6.7 µM and > 200 µM for hIL1R1,hIL1R2 and hIL1R1, respectively). Blocks IL-1-induced expression of ICAM-1 and reduces IL-1β-induced IL-6 and IL-8 production. Also exhibits anti-inflammatory activity. Active in vivo MW 1895.14.

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1 Images
Chemical Structure - AF12198, human type I interleukin receptor antagonist (AB141983)
  • Chemical Structure

Lab

Chemical Structure - AF12198, human type I interleukin receptor antagonist (AB141983)

2D chemical structure image of ab141983, AF12198, human type I interleukin receptor antagonist

Key facts

CAS number

185413-30-3

Form

Solid

form

Formulation

Constituents: 100% AF12198

Molecular weight

1895.14 g/mol

Nature

Synthetic

Solubility

Soluble in 3:1 water/acetonitrile to 1 mg/ml

Biological description

Potent and selective antagonist peptide for human type I interleukin-1 receptor (IL1R1) (IC50 values are 8 nM, > 6.7 µM and > 200 µM for hIL1R1,hIL1R2 and hIL1R1, respectively). Blocks IL-1-induced expression of ICAM-1 and reduces IL-1β-induced IL-6 and IL-8 production. Also exhibits anti-inflammatory activity. Active in vivo.

Isomeric smiles

C[C@H]([C@@H](C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc2c[nH]c3c2cccc3)C(=O)N[C@@H](Cc4ccc(cc4)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N5CCC5C(=O)N[C@@H](Cc6ccc(cc6)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N7CCC[C@H]7C(=O)N[C@@H](CC(C)C)C(=O)N)NC(=O)[C@H](Cc8c[nH]c9c8cccc9)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)C)O

InChi

1S/C96H123N19O22/c1-51(2)41-69(83(98)124)107-92(133)77-24-16-38-113(77)95(136)75(42-52(3)4)111-84(125)53(5)102-86(127)71(44-57-25-29-61(118)30-26-57)110-93(134)78-37-40-115(78)94(135)68(33-35-79(97)120)106-88(129)72(45-58-27-31-62(119)32-28-58)108-89(130)73(46-59-48-99-65-21-13-11-19-63(59)65)104-80(121)50-101-91(132)76-23-15-39-114(76)96(137)82(54(6)116)112-90(131)74(47-60-49-100-66-22-14-12-20-64(60)66)109-85(126)67(34-36-81(122)123)105-87(128)70(103-55(7)117)43-56-17-9-8-10-18-56/h8-14,17-22,25-32,48-49,51-54,67-78,82,99-100,116,118-119H,15-16,23-24,33-47,50H2,1-7H3,(H2,97,120)(H2,98,124)(H,101,132)(H,102,127)(H,103,117)(H,104,121)(H,105,128)(H,106,129)(H,107,133)(H,108,130)(H,109,126)(H,110,134)(H,111,125)(H,112,131)(H,122,123)/t53-,54+,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78?,82-/m0/s1

InChiKey

VASLMBMCJADVGR-BRPRRQPRSA-N

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Product protocols

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Product promise

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