Skip to main content

MW 485.9 Da, Purity >98%. Potent, irreversible Her2/ErbB 2 and EGFR kinase inhibitor (IC50 values are 0.5, 0.4, 10 and 14 nM for EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 respectively). Shows antitumor effects in vivo. Orally active.

Be the first to review this product! Submit a review

Images

Chemical Structure - Afatinib (BIBW 2992), Her2/ErbB 2 and EGFR kinase inhibitor (AB142018), expandable thumbnail

Publications

Key facts

CAS number

850140-72-6

Purity

> 98%

Form

Powder

Molecular weight

485.9 Da

Molecular formula

C24H25ClFN5O3

PubChem identifier

10184653

Nature

Synthetic

Alternative names

Recommended products

MW 485.9 Da, Purity >98%. Potent, irreversible Her2/ErbB 2 and EGFR kinase inhibitor (IC50 values are 0.5, 0.4, 10 and 14 nM for EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 respectively). Shows antitumor effects in vivo. Orally active.

Key facts

Purity

> 98%

PubChem identifier

10184653

Solubility

Soluble in ethanol to 25 mM. Soluble in DMSO to 100 mM.

Biochemical name

Afatinib

Biological description

Potent, irreversible Her2/ErbB 2 and EGFR kinase inhibitor (IC50 values are 0.5, 0.4, 10 and 14 nM for EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 respectively). Shows antitumor effects in vivo. Orally active.

Canonical SMILES

CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4

Isomeric SMILES

CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4

InChI

InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1

InChIKey

ULXXDDBFHOBEHA-CWDCEQMOSA-N

IUPAC name

(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Storage information

Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

IRAK-1 p38 BLK FRK MK2 ErbB3/HER3 ErbB2/HER2 EGFR Lck ErbB4/HER4 ABL1 CK1 epsilon Eph receptor A6 DYRK1A Flt3/CD135 MEK5 GAK PHKG2 MNK1 DYRK2 PHKG1 MNK2 and HIPK4 are proteins with diverse roles in cellular processes. These proteins often referred by alternate names such as EGFR (HER1) and ErbB2 (HER2) vary in molecular weight and structure. For instance afatinib is a molecule targeting EGFR with precise mass properties. Expression of these proteins is observed in various tissues and cell types reflecting their significance in cellular function.

Biological function summary

Many of these proteins like EGFR and HER2 function as part of larger receptor complexes involved in signal transduction. They play important roles in cell proliferation differentiation and survival. For example HER2 is an important member of the ErbB family receptor complex contributing to signal amplification. Proteins like MK2 interact with p38 to mediate cellular responses to external stress factors. Expression patterns of these proteins affect cellular behavior significantly.

Pathways

These proteins partake in important signaling pathways such as the MAPK/ERK and PI3K/AKT pathways. EGFR and HER2 signal through these pathways influencing cell growth and survival. Their interactions with other proteins like PI3K allow for cross-talk between signaling pathways. These pathways are essential for cellular response to growth factors and stress signals thereby modulating cell fate decisions.

Associated diseases and disorders

Aberrant function or expression of these proteins often relates to cancer and inflammatory diseases. Overexpression of EGFR and HER2 is commonly associated with breast and lung cancer as they drive uncontrolled cell proliferation. ABL1 is linked to chronic myeloid leukemia through its fusion with the BCR protein. Therapeutic agents like afatinib and its analogs target these proteins to manage and treat such diseases by inhibiting their activity and altering disease progression.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • Chemical Structure - Afatinib (BIBW 2992), Her2/ErbB 2 and EGFR kinase inhibitor (ab142018), expandable thumbnail

    Chemical Structure - Afatinib (BIBW 2992), Her2/ErbB 2 and EGFR kinase inhibitor (ab142018)

    2D chemical structure image of ab142018, Afatinib (BIBW 2992), Her2/ErbB 2 and EGFR kinase inhibitor

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com