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MW 354.45 g/mol, Purity >98%. Roscovitine-related purine with no activity on CDKS. Selectively and potently increases production of extracellular Aβ42 and decreases production of extracellular Aβ38 in cultured cells. Extracellular Aβ40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting γ-secretase activity toward Aβ42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains.

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Key facts

Purity
> 98%
Form
Solid
Molecular weight
354.45 g/mol
Molecular formula
C19H26N6O
Nature
Synthetic

Target data

Recommended products

MW 354.45 g/mol, Purity >98%. Roscovitine-related purine with no activity on CDKS. Selectively and potently increases production of extracellular Aβ42 and decreases production of extracellular Aβ38 in cultured cells. Extracellular Aβ40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting γ-secretase activity toward Aβ42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains.

Key facts

Purity
> 98%
Solubility

Soluble in DMSO.

Soluble in ethanol.

Biological description

Roscovitine-related purine with no activity on CDKS. Selectively and potently increases production of extracellular Aβ42 and decreases production of extracellular Aβ38 in cultured cells. Extracellular Aβ40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting γ-secretase activity toward Aβ42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains.

Isomeric SMILES
CC(C)N1C2=NC(N[C@@H](CO)CC)=NC(N(C)C3=CC=CC=C3)=C2N=C1
InChI
InChI=1S/C19H26N6O/c1-5-14(11-26)21-19-22-17(24(4)15-9-7-6-8-10-15)16-18(23-19)25(12-20-16)13(2)3/h6-10,12-14,26H,5,11H2,1-4H3,(H,21,22,23)/t14-/m1/s1
InChIKey
HYFZLABHJHEEFS-CQSZACIVSA-N
IUPAC name
(2R)-2-[[9-Isopropyl-6-(N-methylanilino)purin-2-yl]amino]butan-1-ol

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes

Notes

This product is manufactured by BioVision, an Abcam company and was previously called 2575 Aftin-5. 2575-1 is the same size as the 1 mg size of ab285376.

Protect from air and light.

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