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AB141438

AG 1478, EGF receptor tyrosine kinase inhibitor

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(1 Publication)

MW 314.8 Da, Purity >98%. Selective EGF receptor tyrosine kinase inhibitor (Ki = 10 nM). Supresses proliferation and cell-cycle progression. Cell-permeable and active in vivo.
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Chemical Structure - AG 1478, EGF receptor tyrosine kinase inhibitor (AB141438)
  • Chemical Structure

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Chemical Structure - AG 1478, EGF receptor tyrosine kinase inhibitor (AB141438)

2D chemical structure image of ab141438, AG 1478, EGF receptor tyrosine kinase inhibitor

Key facts

CAS number

175178-82-2

Purity

>98%

Form

Solid

form

Molecular weight

314.8 Da

Molecular formula

C<sub>1</sub><sub>7</sub>H<sub>1</sub><sub>5</sub>ClN<sub>2</sub>O<sub>2</sub>

PubChem

53429216

Nature

Synthetic

Solubility

Soluble in ethanol to 25 mM

Soluble in DMSO to 100 mM

Biochemical name

4-[(3-Chlorophenyl)methyl]-6,7-dimethoxyquinazoline

Biological description

Selective EGF receptor tyrosine kinase inhibitor (Ki = 10 nM). Supresses proliferation and cell-cycle progression. Cell-permeable and active in vivo.

Canonical smiles

COC1=C(C=C2C(=C1)C(=NC=N2)CC3=CC(=CC=C3)Cl)OC

InChi

InChI=1S/C17H15ClN2O2/c1-21-16-8-13-14(7-11-4-3-5-12(18)6-11)19-10-20-15(13)9-17(16)22-2/h3-6,8-10H,7H2,1-2H3

InChiKey

DOBKKEHYAFERJH-UHFFFAOYSA-N

IUPAC Name

4-[(3-chlorophenyl)methyl]-6,7-dimethoxyquinazoline

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Biochemicals

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 21: PubMed33302499

2020

Establishment of a Null Murine Oral Carcinoma Cell Line and the Identification of Genetic Alterations Associated with This Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Kuo-Wei Chang,Chia-En Lin,Hsi-Feng Tu,Hsin-Yao Chung,Yi-Fen Chen,Shu-Chun Lin
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Product promise

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