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MW 294.3 Da, Purity >99%. JAK2/3 inhibitor (IC50 values are ~10 and 25 μM, respectively). Inhibits downstream activation of STAT5a/b. Effects synaptic plasticity and cytokine-independent cell growth in vitro and spatial learning, memory and tumor cell invasion in vivo.
Alternative names=EC 2.7.10.2, JAK L, JAK2_HUMAN, JAK3 HUMAN, JAK3_HUMAN, JTK 10, Janus Activating Kinase 2, Janus kinase 2, Janus kinase 2 (a protein tyrosine kinase), Janus kinase 3, Janus kinase 3 (a protein tyrosine kinase, leukocyte), L-JAK, Leukocyte janus kinase, OTTHUMP00000043260, Protein tyrosine kinase leukocyte, THCYT3, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase JAK3, kinase Jak2
- CAS number
133550-30-8
- Purity
> 99%
- Form
Solid
- Molecular weight
294.3 Da
- Molecular formula
C17H14N2O3
- PubChem identifier
5328779
- Nature
Synthetic
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MW 294.3 Da, Purity >99%. JAK2/3 inhibitor (IC50 values are ~10 and 25 μM, respectively). Inhibits downstream activation of STAT5a/b. Effects synaptic plasticity and cytokine-independent cell growth in vitro and spatial learning, memory and tumor cell invasion in vivo.
Alternative names=EC 2.7.10.2, JAK L, JAK2_HUMAN, JAK3 HUMAN, JAK3_HUMAN, JTK 10, Janus Activating Kinase 2, Janus kinase 2, Janus kinase 2 (a protein tyrosine kinase), Janus kinase 3, Janus kinase 3 (a protein tyrosine kinase, leukocyte), L-JAK, Leukocyte janus kinase, OTTHUMP00000043260, Protein tyrosine kinase leukocyte, THCYT3, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase JAK3, kinase Jak2
Key facts
- CAS number
133550-30-8
- Purity
> 99%
- Form
Solid
- Molecular weight
294.3 Da
- Molecular formula
C17H14N2O3
- PubChem identifier
5328779
- Nature
Synthetic
- Biochemical name
Tyrphostin B42
- Biological description
JAK2/3 inhibitor (IC50 values are ~10 and 25 μM, respectively). Inhibits downstream activation of STAT5a/b. Effects synaptic plasticity and cytokine-independent cell growth in vitro and spatial learning, memory and tumor cell invasion in vivo.
- Canonical SMILES
C1=CC=C(C=C1)CNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N
- Isomeric SMILES
C1=CC=C(C=C1)CNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N
- InChI
InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+
- InChIKey
TUCIOBMMDDOEMM-RIYZIHGNSA-N
- IUPAC name
(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
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