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MW 280.28 Da, Purity >99%. Potent, selective EGF receptor tyrosine kinase inhibitor (IC50 = 0.7 μM). Selective over ErbB2, PDGF receptor tyrosine kinase and insulin receptor (IC50 values are 42, 6 and 100 μM respectively). Blocks CDK2 activation leading to cell cycle arrest at late G1 and during S phase.
Alternative names=26S proteasome non-ATPase regulatory subunit 14, 26S proteasome regulatory subunit rpn11, 26S proteasome-associated PAD1 homolog, 26S proteasome-associated PAD1 homolog 1, AAD20, Avian erythroblastic leukemia viral (v erb b) oncogene homolog, Cell growth inhibiting protein 40, Cell proliferation inducing protein 61, DKFZp686O15119, EGFR_HUMAN, ERBB, ERBB1, Epidermal growth factor receptor, Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog), Epidermal growth factor receptor (erythroblastic leukemia viral (v erb b) oncogene homolog avian), Errp, FLJ10358, GAC, GAM, GLS, GLS1, GLSK_HUMAN, Glutaminase C, Glutaminase kidney isoform, Glutaminase phosphate activated, HER1, K-glutaminase, KGA, KIAA0838, L-glutamine amidohydrolase, NISBD2, Oncogen ERBB, PAD1, PAD1, yeast, homolog of, PIG61, POH1, PSDE_HUMAN, Proteasome (prosome, macropain) 26S subunit, non-ATPase, 14, Proteasome 26S subunit non ATPase 14, Proto-oncogene c-ErbB-1, RPN11, Receptor tyrosine-protein kinase ErbB-1, SA7, Species antigen 7, Testis tissue sperm binding protein Li 69n, Urogastrone, Wa5, erb-b2 receptor tyrosine kinase 1, mENA, mitochondrial, v-erb-b Avian erythroblastic leukemia viral oncogen homolog, wa2
- CAS number
133550-35-3
- Purity
> 99%
- Form
Solid
- Molecular weight
280.28 Da
- Molecular formula
C16H12N2O3
- PubChem identifier
5328771
- Nature
Synthetic
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MW 280.28 Da, Purity >99%. Potent, selective EGF receptor tyrosine kinase inhibitor (IC50 = 0.7 μM). Selective over ErbB2, PDGF receptor tyrosine kinase and insulin receptor (IC50 values are 42, 6 and 100 μM respectively). Blocks CDK2 activation leading to cell cycle arrest at late G1 and during S phase.
Alternative names=26S proteasome non-ATPase regulatory subunit 14, 26S proteasome regulatory subunit rpn11, 26S proteasome-associated PAD1 homolog, 26S proteasome-associated PAD1 homolog 1, AAD20, Avian erythroblastic leukemia viral (v erb b) oncogene homolog, Cell growth inhibiting protein 40, Cell proliferation inducing protein 61, DKFZp686O15119, EGFR_HUMAN, ERBB, ERBB1, Epidermal growth factor receptor, Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog), Epidermal growth factor receptor (erythroblastic leukemia viral (v erb b) oncogene homolog avian), Errp, FLJ10358, GAC, GAM, GLS, GLS1, GLSK_HUMAN, Glutaminase C, Glutaminase kidney isoform, Glutaminase phosphate activated, HER1, K-glutaminase, KGA, KIAA0838, L-glutamine amidohydrolase, NISBD2, Oncogen ERBB, PAD1, PAD1, yeast, homolog of, PIG61, POH1, PSDE_HUMAN, Proteasome (prosome, macropain) 26S subunit, non-ATPase, 14, Proteasome 26S subunit non ATPase 14, Proto-oncogene c-ErbB-1, RPN11, Receptor tyrosine-protein kinase ErbB-1, SA7, Species antigen 7, Testis tissue sperm binding protein Li 69n, Urogastrone, Wa5, erb-b2 receptor tyrosine kinase 1, mENA, mitochondrial, v-erb-b Avian erythroblastic leukemia viral oncogen homolog, wa2
Key facts
- CAS number
133550-35-3
- Purity
> 99%
- Form
Solid
- Molecular weight
280.28 Da
- Molecular formula
C16H12N2O3
- PubChem identifier
5328771
- Nature
Synthetic
- Biochemical name
Tyrphostin B48
- Biological description
Potent, selective EGF receptor tyrosine kinase inhibitor (IC50 = 0.7 μM). Selective over ErbB2, PDGF receptor tyrosine kinase and insulin receptor (IC50 values are 42, 6 and 100 μM respectively). Blocks CDK2 activation leading to cell cycle arrest at late G1 and during S phase.
- Canonical SMILES
C1=CC=C(C=C1)NC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N
- Isomeric SMILES
C1=CC=C(C=C1)NC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N
- InChI
InChI=1S/C16H12N2O3/c17-10-12(8-11-6-7-14(19)15(20)9-11)16(21)18-13-4-2-1-3-5-13/h1-9,19-20H,(H,18,21)/b12-8+
- InChIKey
HKHOVJYOELRGMV-XYOKQWHBSA-N
- IUPAC name
(E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-2-enamide
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
Ambient
- Storage information
The product can be stored for up to 12 months
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