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AB146594

AICAR (Acadesine/AICA riboside) (aqueous solution), protein kinase activator

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MW 258.23 Da, Purity >98%. Cell-permeable activator of AMP-activated protein kinase. Is taken up into cells by adenosine transporters and phosphorylated by adenosine kinase to the active nucleotide ZMP (5-aminoimidazole-4-carboxamide ribonucleoside), which mimics effects of AMP on the AMPK system. Active in vivo and in vitro.

View Alternative Names

Non receptor tyrosine phosphatase 1, PTN1_HUMAN, PTP-1B, PTPN 1, Protein phosphotyrosylphosphatase 1B, Protein tyrosine phosphatase non receptor type 1, Protein tyrosine phosphatase placental, Protein-tyrosine phosphatase 1B, Tyrosine-protein phosphatase non-receptor type 1

1 Images
Chemical Structure - AICAR (Acadesine/AICA riboside) (aqueous solution), protein kinase activator (AB146594)
  • Chemical Structure

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Chemical Structure - AICAR (Acadesine/AICA riboside) (aqueous solution), protein kinase activator (AB146594)

2D chemical structure image of ab146594, AICAR (Acadesine/AICA riboside) (aqueous solution), protein kinase activator

Key facts

CAS number

2627-69-2

Purity

>98%

Form

Liquid

form

Molecular weight

258.23 Da

Molecular formula

C<sub>9</sub>H<sub>1</sub><sub>4</sub>N<sub>4</sub>O<sub>5</sub>

PubChem

17513

Nature

Synthetic

Biochemical name

Acadesine

Biological description

Cell-permeable activator of AMP-activated protein kinase. Is taken up into cells by adenosine transporters and phosphorylated by adenosine kinase to the active nucleotide ZMP (5-aminoimidazole-4-carboxamide ribonucleoside), which mimics effects of AMP on the AMPK system. Active in vivo and in vitro.

Canonical smiles

C1=NC(=C(N1C2C(C(C(O2)CO)O)O)N)C(=O)N

Isomeric smiles

C1=NC(=C(N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N)C(=O)N

InChi

InChI=1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1

InChiKey

RTRQQBHATOEIAF-UUOKFMHZSA-N

IUPAC Name

5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazole-4-carboxamide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|Store under desiccating conditions|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
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Product protocols

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