AB142088

Akt Inhibitor (Akti-1/2), Akt1/2 kinase inhibitor

Name: Akt Inhibitor (Akti-1/2), Akt1/2 kinase inhibitor (ab142088) | Abcam
Brand: Abcam Limited
SKU: AB142088
Price: 245 USD
Availability: InStock

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(19 Publications)

MW 551.6 Da, Purity >99%. Potent isozyme selective Akt1/2 kinase inhibitor. (IC₅₀ values are 58, 210 nM and 2.12 mM for Akt1, Akt2, and Akt3, respectively). No inhibition against pleckstrin homology (PH) domain-lacking Akts, PKA, PKC and SGK.

1 Images

Chemical Structure - Akt Inhibitor (Akti-1/2), Akt1/2 kinase inhibitor (AB142088)

Chemical Structure

Lab

Chemical Structure - Akt Inhibitor (Akti-1/2), Akt1/2 kinase inhibitor (AB142088)

2D chemical structure image of ab142088, Akt Inhibitor (Akti-1/2), Akt1/2 kinase inhibitor

Key facts

Purity

>99%

Form

Solid

form

Molecular weight

551.6 Da

Molecular formula

C34H29N7O

PubChem

10196499

Nature

Synthetic

Solubility

Soluble in DMSO to 10 mM

Biochemical name

CID 10196499

Biological description

Potent isozyme selective Akt1/2 kinase inhibitor. (IC₅₀ values are 58, 210 nM and 2.12 mM for Akt1, Akt2, and Akt3, respectively). No inhibition against pleckstrin homology (PH) domain-lacking Akts, PKA, PKC and SGK.

Canonical smiles

C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC=C(C=C4)C5=NC6=C(C=C7C(=C6)NC=N7)N=C5C8=CC=CC=C8

Isomeric smiles

C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC=C(C=C4)C5=NC6=C(C=C7C(=C6)NC=N7)N=C5C8=CC=CC=C8

InChi

InChI=1S/C34H29N7O/c42-34-39-26-8-4-5-9-31(26)41(34)25-14-16-40(17-15-25)20-22-10-12-24(13-11-22)33-32(23-6-2-1-3-7-23)37-29-18-27-28(36-21-35-27)19-30(29)38-33/h1-13,18-19,21,25H,14-17,20H2,(H,35,36)(H,39,42)

InChiKey

BIWGYFZAEWGBAL-UHFFFAOYSA-N

IUPAC Name

3-[1-[[4-(7-phenyl-3H-imidazo[4,5-g]quinoxalin-6-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one

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Properties and storage information

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Storage information

Store under desiccating conditions|The product can be stored for up to 12 months

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Product protocols

Visit the General protocols
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Publications (19)

Recent publications for all applications. Explore the full list and refine your search

Science signaling 16:eabo6555 PubMed37874883

2023

Human IL-17A protein production is controlled through a PIP5K1α-dependent translational checkpoint.

Applications

Unspecified application

Species

Unspecified reactive species

Shankar K Revu,Wenjuan Yang,Dhivyaa Rajasundaram,Alexander Brady,Saikat Majumder,Sarah L Gaffen,William Hawse,Zongqi Xia,Mandy J McGeachy

Molecular oncology 16:3642-3653 PubMed35973936

2022

Sphingosine-1-phosphate-lyase deficiency affects glucose metabolism in a way that abets oncogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Sumaiya Y Afsar,Shah Alam,Carina Fernandez Gonzalez,Gerhild van Echten-Deckert

Cell biology international 46:1480-1494 PubMed35673985

2022

RNA-seq and ATAC-seq analyses of multilineage differentiating stress enduring cells: Comparison with dermal fibroblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Qian Mao,Yan Cheng,Ru-Zhi Zhang,Yi-Bo Liu,Yue Li,Kang Ge,Hui-Ling Jin

Cell cycle (Georgetown, Tex.) 21:1697-1709 PubMed35485293

2022

Suppression of CX3CL1 by miR-497-5p inhibits cell growth and invasion through inactivating the ERK/AKT pathway in NSCLC cells.

Applications

Unspecified application

Species

Unspecified reactive species

Wen Tang,Ping Jia,Lin Zuo,Jia Zhao

Cancer cell international 22:13 PubMed34996459

2022

Hypoxia-mediated YTHDF2 overexpression promotes lung squamous cell carcinoma progression by activation of the mTOR/AKT axis.

Applications

Unspecified application

Species

Unspecified reactive species

Peng Xu,Kang Hu,Ping Zhang,Zhi-Gang Sun,Nan Zhang

Science signaling 14: PubMed34131021

2021

The costimulatory activity of Tim-3 requires Akt and MAPK signaling and its recruitment to the immune synapse.

Applications

Unspecified application

Species

Unspecified reactive species

Shunsuke Kataoka,Priyanka Manandhar,Judong Lee,Creg J Workman,Hridesh Banerjee,Andrea L Szymczak-Workman,Michael Kvorjak,Jason Lohmueller,Lawrence P Kane

Journal of virology : PubMed32967962

2020

White spot syndrome virus benefits from endosomal trafficking, substantially facilitated by a valosin-containing protein, to escape autophagic elimination and propagate in crustacean .

Applications

Unspecified application

Species

Unspecified reactive species

Chuang Meng,Ling-Ke Liu,Dong-Li Li,Rui-Lin Gao,Wei-Wei Fan,Ke-Jian Wang,Han-Ching Wang,Hai-Peng Liu

Cell reports 29:3385-3393.e6 PubMed31825823

2019

PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Elizabeth Foxall,Adela Staszowska,Liisa M Hirvonen,Mirella Georgouli,Mariacristina Ciccioli,Alexander Rimmer,Lynn Williams,Yolanda Calle,Victoria Sanz-Moreno,Susan Cox,Gareth E Jones,Claire M Wells

Frontiers in cellular neuroscience 13:437 PubMed31680862

2019

Proteomic Identification of Pathways Responsible for the Estradiol Therapeutic Window in AD Animal Models.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Cui,Jon Reed,Gogce Crynen,Ghania Ait-Ghezala,Fiona Crawford,Yong Shen,Rena Li

Molecular medicine reports 20:2812-2822 PubMed31322233

2019

The role of Zeb1 in the pathogenesis of morbidly adherent placenta.

Applications

Unspecified application

Species

Unspecified reactive species

Na Li,Tian Yang,Wenqian Yu,Hao Liu,Chong Qiao,Caixia Liu

View all publications

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Akt Inhibitor (Akti-1/2), Akt1/2 kinase inhibitor

Chemical Structure - Akt Inhibitor (Akti-1/2), Akt1/2 kinase inhibitor (AB142088)

Key facts

Purity

Form

Molecular weight

Molecular formula

PubChem

Nature

Solubility

Biochemical name

Biological description

Canonical smiles

Isomeric smiles

InChi

InChiKey

IUPAC Name

Properties and storage information

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Product protocols

Publications (19)

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