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AB147022

Alloswitch-1, mGlu5 modulator

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MW 366.8 Da, Purity >98%. Photoswitchable allosteric modulator selective for the metabotropic glutamate receptor mGlu5. Acts as a potent NAM (negative allosteric modulator) in dark or under green light but loses its NAM potency under violet light when photoisomerized.

Key facts

Purity

>98%

Form

Solid

form

Formulation

Constituents: 100% Alloswitch-1

Molecular weight

366.8 Da

Molecular formula

C<sub>1</sub><sub>9</sub>H<sub>1</sub><sub>5</sub>ClN<sub>4</sub>O<sub>2</sub>

PubChem

76853680

Nature

Synthetic

Solubility

Soluble in ethanol to 10 mM

Soluble in DMSO to 100 mM

Biochemical name

Alloswitch-1

Biological description

Photoswitchable allosteric modulator selective for the metabotropic glutamate receptor mGlu5. Acts as a potent NAM (negative allosteric modulator) in dark or under green light but loses its NAM potency under violet light when photoisomerized.

Canonical smiles

COC1=C(C=CC(=C1)N=NC2=CC=CC=N2)NC(=O)C3=CC=CC=C3Cl

InChi

InChI=1S/C19H15ClN4O2/c1-26-17-12-13(23-24-18-8-4-5-11-21-18)9-10-16(17)22-19(25)14-6-2-3-7-15(14)20/h2-12H,1H3,(H,22,25)

InChiKey

JJRNGNCTPCWXGM-UHFFFAOYSA-N

IUPAC Name

2-chloro-N-[2-methoxy-4-(pyridin-2-yldiazenyl)phenyl]benzamide

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Primary Antibodies

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Anti-SRPX2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-SRPX2 antibody (AB91584)

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Secondary Antibodies

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|Store under desiccating conditions
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Product protocols

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Product promise

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