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MW 267.33 g/mol. Cell-permeable, potent, selective, reversible, ATP-competitive inhibitor of CDK1/cyclin B (IC50 = 150nM), CDK2/cyclin A (IC50 = 120nM), CDK2/cyclin E (IC50 = 400nM), CDK5/p25 (IC50 = 200nM), CDK5/p35 (IC50 = 160nM) and GSK-3α (IC50 = 500nM). Also inhibits GSK-3β (IC50 = 650nM) and c-Jun N-terminal kinase (JNK) (IC50 = ~3-10μM). Poor inhibitor of CK1, CK2, CDK4/cyclin D1, MAPKK, PKA, PKG, PKCs and c-raf (IC50≥100μM). Blocks cell cycle progression in both G1 and G2 phase.

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Images

Chemical Structure - Aloisine A, CDK inhibitor (AB143750), expandable thumbnail

Key facts

CAS number
496864-16-5
Molecular weight
267.33 g/mol
Molecular formula
C16H17N3O
Nature
Synthetic

Target data

Recommended products

MW 267.33 g/mol. Cell-permeable, potent, selective, reversible, ATP-competitive inhibitor of CDK1/cyclin B (IC50 = 150nM), CDK2/cyclin A (IC50 = 120nM), CDK2/cyclin E (IC50 = 400nM), CDK5/p25 (IC50 = 200nM), CDK5/p35 (IC50 = 160nM) and GSK-3α (IC50 = 500nM). Also inhibits GSK-3β (IC50 = 650nM) and c-Jun N-terminal kinase (JNK) (IC50 = ~3-10μM). Poor inhibitor of CK1, CK2, CDK4/cyclin D1, MAPKK, PKA, PKG, PKCs and c-raf (IC50≥100μM). Blocks cell cycle progression in both G1 and G2 phase.

Key facts

Solubility

DMSO.

Biological description

Cell-permeable, potent, selective, reversible, ATP-competitive inhibitor of CDK1/cyclin B (IC50 = 150nM), CDK2/cyclin A (IC50 = 120nM), CDK2/cyclin E (IC50 = 400nM), CDK5/p25 (IC50 = 200nM), CDK5/p35 (IC50 = 160nM) and GSK-3α (IC50 = 500nM). Also inhibits GSK-3β (IC50 = 650nM) and c-Jun N-terminal kinase (JNK) (IC50 = ~3-10μM). Poor inhibitor of CK1, CK2, CDK4/cyclin D1, MAPKK, PKA, PKG, PKCs and c-raf (IC50≥100μM). Blocks cell cycle progression in both G1 and G2 phase.

IUPAC name
4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

Product promise

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1 product image

  • Chemical Structure - Aloisine A, CDK inhibitor (ab143750), expandable thumbnail

    Chemical Structure - Aloisine A, CDK inhibitor (ab143750)

    2D chemical structure image of ab143750, Aloisine A, CDK inhibitor

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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