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AB143750

Aloisine A, CDK inhibitor

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MW 267.33 g/mol. Cell-permeable, potent, selective, reversible, ATP-competitive inhibitor of CDK1/cyclin B (IC50 = 150nM), CDK2/cyclin A (IC50 = 120nM), CDK2/cyclin E (IC50 = 400nM), CDK5/p25 (IC50 = 200nM), CDK5/p35 (IC50 = 160nM) and GSK-3α (IC50 = 500nM). Also inhibits GSK-3β (IC50 = 650nM) and c-Jun N-terminal kinase (JNK) (IC50 = ~3-10μM). Poor inhibitor of CK1, CK2, CDK4/cyclin D1, MAPKK, PKA, PKG, PKCs and c-raf (IC50≥100μM). Blocks cell cycle progression in both G1 and G2 phase.
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Chemical Structure - Aloisine A, CDK inhibitor (AB143750)
  • Chemical Structure

Lab

Chemical Structure - Aloisine A, CDK inhibitor (AB143750)

2D chemical structure image of ab143750, Aloisine A, CDK inhibitor

Key facts

CAS number

496864-16-5

Molecular weight

267.33 g/mol

Molecular formula

C<sub>1</sub><sub>6</sub>H<sub>1</sub><sub>7</sub>N<sub>3</sub>O

Nature

Synthetic

Solubility

DMSO

Biological description

Cell-permeable, potent, selective, reversible, ATP-competitive inhibitor of CDK1/cyclin B (IC50 = 150nM), CDK2/cyclin A (IC50 = 120nM), CDK2/cyclin E (IC50 = 400nM), CDK5/p25 (IC50 = 200nM), CDK5/p35 (IC50 = 160nM) and GSK-3α (IC50 = 500nM). Also inhibits GSK-3β (IC50 = 650nM) and c-Jun N-terminal kinase (JNK) (IC50 = ~3-10μM). Poor inhibitor of CK1, CK2, CDK4/cyclin D1, MAPKK, PKA, PKG, PKCs and c-raf (IC50≥100μM). Blocks cell cycle progression in both G1 and G2 phase.

IUPAC Name

4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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