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MW 1665.9 Da, Purity >95%. alpha-MSH (free acid), Endogenous melanocortin receptor agonist. Achieve your results faster with highly validated, pure and trusted compounds.

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Images

Chemical Structure - alpha-MSH (free acid), Endogenous melanocortin receptor agonist (AB120205), expandable thumbnail
  • Functional Studies - alpha-MSH (free acid), Endogenous melanocortin receptor agonist (AB120205), expandable thumbnail

Publications

Key facts

CAS number
10466-28-1
Purity
> 95%
Form
Solid
Molecular weight
1665.9 Da
Molecular formula
C77H108N20O20S
PubChem identifier
16131203
Nature
Synthetic

Target data

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MW 1665.9 Da, Purity >95%. alpha-MSH (free acid), Endogenous melanocortin receptor agonist. Achieve your results faster with highly validated, pure and trusted compounds.

Key facts

Purity
> 95%
PubChem identifier
16131203
Solubility

Soluble in water.

Biochemical name
Ac-Ser-Tyr-Ser-Met-Glu-DL-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-OH
Canonical SMILES
CC(C)C(C(=O)O)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)CNC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC5=CN=CN5)NC(=O)C(CCC(=O)O)NC(=O)C(CCSC)NC(=O)C(CO)NC(=O)C(CC6=CC=C(C=C6)O)NC(=O)C(CO)NC(=O)C
Isomeric SMILES
CC(C)[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)C(CC5=CN=CN5)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CC6=CC=C(C=C6)O)NC(=O)[C@H](CO)NC(=O)C
InChI
InChI=1S/C77H108N20O20S/c1-42(2)64(76(116)117)96-74(114)61-20-13-30-97(61)75(115)54(18-10-11-28-78)87-62(102)38-84-65(105)57(34-46-36-83-50-17-9-8-16-49(46)50)93-66(106)51(19-12-29-82-77(79)80)88-69(109)55(32-44-14-6-5-7-15-44)91-71(111)58(35-47-37-81-41-85-47)94-67(107)52(25-26-63(103)104)89-68(108)53(27-31-118-4)90-73(113)60(40-99)95-70(110)56(33-45-21-23-48(101)24-22-45)92-72(112)59(39-98)86-43(3)100/h5-9,14-17,21-24,36-37,41-42,51-61,64,83,98-99,101H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H,81,85)(H,84,105)(H,86,100)(H,87,102)(H,88,109)(H,89,108)(H,90,113)(H,91,111)(H,92,112)(H,93,106)(H,94,107)(H,95,110)(H,96,114)(H,103,104)(H,116,117)(H4,79,80,82)/t51-,52-,53-,54-,55-,56-,57-,58?,59-,60-,61-,64-/m0/s1
InChIKey
MBBQINYFFIKILA-PDEGJNOBSA-N
IUPAC name
(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-[[1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-6-amino-1-[(2S)-2-[[(1S)-1-carboxy-2-methylpropyl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

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2 product images

  • Chemical Structure - alpha-MSH (free acid), Endogenous melanocortin receptor agonist (ab120205), expandable thumbnail

    Chemical Structure - alpha-MSH (free acid), Endogenous melanocortin receptor agonist (ab120205)

    2D chemical structure image of ab120205, alpha-MSH (free acid), Endogenous melanocortin receptor agonist

  • Functional Studies - alpha-MSH (free acid), Endogenous melanocortin receptor agonist (ab120205), expandable thumbnail

    Functional Studies - alpha-MSH (free acid), Endogenous melanocortin receptor agonist (ab120205)

    ab24851 staining cAMP in MALME-3M cells treated with α-MSH (ab120205), by ICC/IF. Increase of cAMP correlates with increased concentration of α-MSH, as described in literature.
    The cells were incubated at 37°C for 2h in media containing different concentrations of ab120205 (α-MSH) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab24851 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-mouse polyclonal antibody (Goat Anti-Mouse IgG H&L (DyLight® 488) preadsorbed ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

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