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AB120205

alpha-MSH (free acid), Endogenous melanocortin receptor agonist

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(1 Publication)

MW 1665.9 Da, Purity >95%. Achieve your results faster with highly validated, pure and trusted compounds.
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Functional Studies - alpha-MSH (free acid), Endogenous melanocortin receptor agonist (AB120205)
  • FuncS

Unknown

Functional Studies - alpha-MSH (free acid), Endogenous melanocortin receptor agonist (AB120205)

ab24851 staining cAMP in MALME-3M cells treated with α-MSH (ab120205), by ICC/IF. Increase of cAMP correlates with increased concentration of α-MSH, as described in literature.
The cells were incubated at 37°C for 2h in media containing different concentrations of ab120205 (α-MSH) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab24851 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 goat anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - alpha-MSH (free acid), Endogenous melanocortin receptor agonist (AB120205)
  • Chemical Structure

Lab

Chemical Structure - alpha-MSH (free acid), Endogenous melanocortin receptor agonist (AB120205)

2D chemical structure image of ab120205, alpha-MSH (free acid), Endogenous melanocortin receptor agonist

Key facts

CAS number

10466-28-1

Purity

>95%

Form

Solid

form

Molecular weight

1665.9 Da

Molecular formula

C<sub>7</sub><sub>7</sub>H<sub>1</sub><sub>0</sub><sub>8</sub>N<sub>2</sub><sub>0</sub>O<sub>2</sub><sub>0</sub>S

PubChem

16131203

Nature

Synthetic

Solubility

Soluble in water

Biochemical name

Ac-Ser-Tyr-Ser-Met-Glu-DL-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-OH

Canonical smiles

CC(C)C(C(=O)O)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)CNC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC5=CN=CN5)NC(=O)C(CCC(=O)O)NC(=O)C(CCSC)NC(=O)C(CO)NC(=O)C(CC6=CC=C(C=C6)O)NC(=O)C(CO)NC(=O)C

Isomeric smiles

CC(C)[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)C(CC5=CN=CN5)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CC6=CC=C(C=C6)O)NC(=O)[C@H](CO)NC(=O)C

InChi

InChI=1S/C77H108N20O20S/c1-42(2)64(76(116)117)96-74(114)61-20-13-30-97(61)75(115)54(18-10-11-28-78)87-62(102)38-84-65(105)57(34-46-36-83-50-17-9-8-16-49(46)50)93-66(106)51(19-12-29-82-77(79)80)88-69(109)55(32-44-14-6-5-7-15-44)91-71(111)58(35-47-37-81-41-85-47)94-67(107)52(25-26-63(103)104)89-68(108)53(27-31-118-4)90-73(113)60(40-99)95-70(110)56(33-45-21-23-48(101)24-22-45)92-72(112)59(39-98)86-43(3)100/h5-9,14-17,21-24,36-37,41-42,51-61,64,83,98-99,101H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H,81,85)(H,84,105)(H,86,100)(H,87,102)(H,88,109)(H,89,108)(H,90,113)(H,91,111)(H,92,112)(H,93,106)(H,94,107)(H,95,110)(H,96,114)(H,103,104)(H,116,117)(H4,79,80,82)/t51-,52-,53-,54-,55-,56-,57-,58?,59-,60-,61-,64-/m0/s1

InChiKey

MBBQINYFFIKILA-PDEGJNOBSA-N

IUPAC Name

(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-[[1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-6-amino-1-[(2S)-2-[[(1S)-1-carboxy-2-methylpropyl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 14:5601 PubMed37699899

2023

Solar ultraviolet B radiation promotes α-MSH secretion to attenuate the function of ILC2s via the pituitary-lung axis.

Applications

Unspecified application

Species

Unspecified reactive species

Yuying Huang,Lin Zhu,Shipeng Cheng,Ranran Dai,Chunrong Huang,Yanyan Song,Bo Peng,Xuezhen Li,Jing Wen,Yi Gong,Yunqian Hu,Ling Qian,Linyun Zhu,Fengying Zhang,Li Yu,Chunyan Yi,Wangpeng Gu,Zhiyang Ling,Liyan Ma,Wei Tang,Li Peng,Guochao Shi,Yaguang Zhang,Bing Sun
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