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MW 293.28 Da, Purity >96%. Potent CDK inhibitor (IC50 values are 3.5 (CDK1/cyclin B), 20 (CDK2/cyclin A) and 40 nM (CDK5/p35)). Also displays potent and selective inhibition of GSK-3β (IC50 values are 40 and 4 nM respectively). Antiproliferative effects seen in vitro. Cell-permeable.
Alternative names=AI838772, AW493413, CCNB, CCNB1_HUMAN, CCNB2_HUMAN, CD5R1_HUMAN, CDC28, CDC28A, CDC2A, CDK1_HUMAN, CDK2_HUMAN, CDK5 activator 1, CDK5P35, CDK5R, CDK5R1, CDK5_HUMAN, CDKN1, CDKN2, CELL CYCLE CONTROLLER CDC2, Cdc 2, Cell Divsion Cycle 2 Protein, Cell devision kinase 2, Cell division control protein 2, Cell division control protein 2 homolog, Cell division cycle 2 G1 to S and G2 to M, Cell division protein kinase 1, Cell division protein kinase 2, Cell division protein kinase 5, Crk6, CycB2, Cyclin B1, Cyclin B2, Cyclin-dependent kinase 1, Cyclin-dependent kinase 2, Cyclin-dependent kinase 5, Cyclin-dependent kinase 5 activator 1, Cyclin-dependent kinase 5 regulatory subunit 1, DKFZP586N0721, DKFZp686D0638, DKFZp686J10186, DKFZp686L20222, FLJ11090, G2 mitotic specific cyclin B1, G2 mitotic specific cyclin B2, G2/mitotic specific cyclin B3, G2/mitotic-specific cyclin-B1, G2/mitotic-specific cyclin-B2, GSK-3 alpha, GSK-3 beta, GSK3A_HUMAN, GSK3B_HUMAN, GSK3beta isoform, Glycogen synthase kinase-3 alpha, Glycogen synthase kinase-3 beta, HSPC193, HST17436, HsT17299, JV15-2, LDS1C, LDS3, MAD (mothers against decapentaplegic Drosophila) homolog 3, MAD homolog 3, MAD, mothers against decapentaplegic homolog 3, MADH 3, MGC104252, MGC108931, MGC111195, MGC112732, MGC140694, MGC60396, MPF, Mad homolog JV15 2, Mad protein homolog, Mothers against DPP homolog 3, Mothers against decapentaplegic homolog 3, NCK 5A, Neuronal CDK5 activator, P23, P34CDC2, P35, PSSALRE, Protein kinase CDK5 splicing, RP11 805H4.3, RP24-311F12.2, Regulatory partner for CDK5 kinase, SCAN1, SMA and MAD related protein 3, SMAD, SMAD family member 3, SMAD, mothers against DPP homolog 3, SMAD3_HUMAN, Serine threonine protein kinase PSSALRE, Serine/threonine protein kinase GSK3A, Serine/threonine-protein kinase GSK3B, Serine/threonine-protein kinase PSSALRE, TPKII catalytic subunit, TPKII regulatory subunit, TYDP, TYDP1_HUMAN, Tau protein kinase II 23 kDa subunit, Tau protein kinase II catalytic subunit, Tyr-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, cdc2-related protein kinase, cyclin dependent kinase 2-alpha, hMAD-3, hSMAD3, kinase Cdc2, p25, p33 protein kinase, p33(CDK2), p34 Cdk1, p34 protein kinase
- CAS number
237430-03-4
- Purity
> 96%
- Form
Solid
- Molecular weight
293.28 Da
- Molecular formula
C16H11N3O3
- PubChem identifier
5005498
- Nature
Synthetic
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MW 293.28 Da, Purity >96%. Potent CDK inhibitor (IC50 values are 3.5 (CDK1/cyclin B), 20 (CDK2/cyclin A) and 40 nM (CDK5/p35)). Also displays potent and selective inhibition of GSK-3β (IC50 values are 40 and 4 nM respectively). Antiproliferative effects seen in vitro. Cell-permeable.
Alternative names=AI838772, AW493413, CCNB, CCNB1_HUMAN, CCNB2_HUMAN, CD5R1_HUMAN, CDC28, CDC28A, CDC2A, CDK1_HUMAN, CDK2_HUMAN, CDK5 activator 1, CDK5P35, CDK5R, CDK5R1, CDK5_HUMAN, CDKN1, CDKN2, CELL CYCLE CONTROLLER CDC2, Cdc 2, Cell Divsion Cycle 2 Protein, Cell devision kinase 2, Cell division control protein 2, Cell division control protein 2 homolog, Cell division cycle 2 G1 to S and G2 to M, Cell division protein kinase 1, Cell division protein kinase 2, Cell division protein kinase 5, Crk6, CycB2, Cyclin B1, Cyclin B2, Cyclin-dependent kinase 1, Cyclin-dependent kinase 2, Cyclin-dependent kinase 5, Cyclin-dependent kinase 5 activator 1, Cyclin-dependent kinase 5 regulatory subunit 1, DKFZP586N0721, DKFZp686D0638, DKFZp686J10186, DKFZp686L20222, FLJ11090, G2 mitotic specific cyclin B1, G2 mitotic specific cyclin B2, G2/mitotic specific cyclin B3, G2/mitotic-specific cyclin-B1, G2/mitotic-specific cyclin-B2, GSK-3 alpha, GSK-3 beta, GSK3A_HUMAN, GSK3B_HUMAN, GSK3beta isoform, Glycogen synthase kinase-3 alpha, Glycogen synthase kinase-3 beta, HSPC193, HST17436, HsT17299, JV15-2, LDS1C, LDS3, MAD (mothers against decapentaplegic Drosophila) homolog 3, MAD homolog 3, MAD, mothers against decapentaplegic homolog 3, MADH 3, MGC104252, MGC108931, MGC111195, MGC112732, MGC140694, MGC60396, MPF, Mad homolog JV15 2, Mad protein homolog, Mothers against DPP homolog 3, Mothers against decapentaplegic homolog 3, NCK 5A, Neuronal CDK5 activator, P23, P34CDC2, P35, PSSALRE, Protein kinase CDK5 splicing, RP11 805H4.3, RP24-311F12.2, Regulatory partner for CDK5 kinase, SCAN1, SMA and MAD related protein 3, SMAD, SMAD family member 3, SMAD, mothers against DPP homolog 3, SMAD3_HUMAN, Serine threonine protein kinase PSSALRE, Serine/threonine protein kinase GSK3A, Serine/threonine-protein kinase GSK3B, Serine/threonine-protein kinase PSSALRE, TPKII catalytic subunit, TPKII regulatory subunit, TYDP, TYDP1_HUMAN, Tau protein kinase II 23 kDa subunit, Tau protein kinase II catalytic subunit, Tyr-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, cdc2-related protein kinase, cyclin dependent kinase 2-alpha, hMAD-3, hSMAD3, kinase Cdc2, p25, p33 protein kinase, p33(CDK2), p34 Cdk1, p34 protein kinase
Key facts
- CAS number
237430-03-4
- Purity
> 96%
- Form
Solid
- Molecular weight
293.28 Da
- Molecular formula
C16H11N3O3
- PubChem identifier
5005498
- Nature
Synthetic
- Biochemical name
Alsterpaullone
- Biological description
Potent CDK inhibitor (IC50 values are 3.5 (CDK1/cyclin B), 20 (CDK2/cyclin A) and 40 nM (CDK5/p35)). Also displays potent and selective inhibition of GSK-3β (IC50 values are 40 and 4 nM respectively). Antiproliferative effects seen in vitro. Cell-permeable.
- Canonical SMILES
C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)[N+](=O)[O-]
- InChI
InChI=1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20)
- InChIKey
OLUKILHGKRVDCT-UHFFFAOYSA-N
- IUPAC name
9-nitro-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
+4°C
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
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