MW 351.4 Da, Purity >98%. Selective RARα agonists (EC50 values are 0.3, 8.6 and 13 nM for RARα, RARβ and RARγ respectively). Shows anticancer effect. Active in vivo..
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1 25 dihydroxyvitamin D3 receptor, 25-dihydroxyvitamin D3 receptor, AIS, ANDR_HUMAN, AR, AR8, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease), Atherosclerosis, susceptibility to, included, BAR, Bile acid receptor, CHNG1, DHTR, DKFZp686N23123, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), ER, ER-alpha, ER-beta, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESRA, ESTR B, Era, Erb, Erb2, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta 4, Estrogen resistance, included, FLJ00280, FLJ00318, FLJ16020, FLJ16733, Farnesoid X-activated receptor, Farnesol receptor HRR-1, HAP, HBV-activated protein, HDL cholesterol, augmented response of, to hormone replacement, included, HRR 1, HUMARA, HYSP1, IMD42, KD, Kennedy disease (KD), LGR 3, MGC102720, MGC129539, MGC75129, Member 1, Myocardial infarction, susceptibility to, included, NF-E2-related factor 2, NF2L2_HUMAN, NR1B1, NR1B2, NR1B3, NR1F3, NR1I1, NR2B1, NR3A1, NR3A2, NR3C4, NRF2, Nfe2l2, Nuclear factor, Nuclear factor (erythroid derived 2) like 2, Nuclear factor erythroid 2-related factor 2, Nuclear factor erythroid derived 2 like 2, Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group B member 1, Nuclear receptor subfamily 1 group B member 2, Nuclear receptor subfamily 1 group B member 3, Nuclear receptor subfamily 1 group F member 3, Nuclear receptor subfamily 1 group I member 1, Nuclear receptor subfamily 2 group B member 1, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form, OTTHUMP00000017718, OTTHUMP00000017719, OTTHUMP00000022510, PPP1R163, Protein phosphatase 1, regulatory subunit 163, RAR, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-alpha, RAR-beta, RAR-epsilon, RAR-gamma, RAR-related orphan receptor C, RARA_HUMAN, RARB_HUMAN, RARC, RARG_HUMAN, RARalpha1, RIP 14, RNESTROR, RORG_HUMAN, RRB2, RXR alpha1, RXR-interacting protein 14, RXRA_HUMAN, RZR GAMMA, RZRG, Retinoic acid binding receptor gamma, Retinoic acid nuclear receptor alpha variant 1, Retinoic acid nuclear receptor alpha variant 2, Retinoic acid receptor RXR-alpha, Retinoic acid receptor alpha, Retinoic acid receptor alpha polypeptide, Retinoic acid receptor beta, Retinoic acid receptor beta 2, Retinoic acid receptor beta 4, Retinoic acid receptor beta 5, Retinoic acid receptor beta polypeptide, Retinoic acid receptor gamma 2, Retinoic acid receptor, gamma, Retinoid X nuclear receptor alpha, Retinoid X receptor alpha, Retinoid X receptor-interacting protein 14, Retinoid-related orphan receptor-gamma, Rorc, SBMA, SMAX1, Seven transmembrane helix receptor, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), TFM, TOR, TSH Receptor, TSHR_HUMAN, Testicular Feminization (TFM), Thyroid adenoma hyperfunctioning, Thyroid carcinoma with thyrotoxicosis, Thyroid stimulating hormone receptor, isoform 2, Thyroid-stimulating hormone receptor, Thyrotropin receptor, Thyrotropin receptor I, Thyrotropin receptor I, hTSHR I, VDR_HUMAN, Vitamin D (1,25- dihydroxyvitamin D3) receptor, Vitamin D hormone receptor, Vitamin D nuclear receptor variant 1, Vitamin D receptor, Vitamin D3 receptor, androgen receptor splice variant 4b, erythroid derived 2, hTSHR I, like 2, nuclear factor erythroid 2 like 2
- Chemical Structure
Lab
Chemical Structure - AM580, RARalpha agonists (AB141314)
2D chemical structure image of ab141314, AM580, RARalpha agonists
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
These nuclear receptors influence major body systems by interacting with hormones or vitamins to regulate gene transcription. They form dimeric or heterodimeric complexes such as RXRA pairing with retinoic acid receptors. RARG VDR and ER modulate cell differentiation proliferation and apoptosis. TSH-R primarily regulates thyroid hormone synthesis influencing metabolism. AR mediates sexual development and reproductive functions while RORA and RARB partakes in embryonic development. ROR gamma is essential for thymopoiesis an aspect of immune defense. Nrf2 manages cellular antioxidant defense by initiating transcription of protective genes promoting cellular resilience against oxidative stress.
Pathways
These receptors integrate into critical signaling networks affecting multiple cellular processes. The retinoic acid-mediated pathway involves RARG RARA and RXRA influencing gene expression for tissue morphogenesis and homeostasis often linked with RXRA partners like PPARs. Similarly the Vitamin D pathway involves VDR impacting calcium and phosphate metabolism through interaction with proteins like calmodulin. Their involvement extends to immune response regulation and metabolic processes wherein ER components intersect with steroid biosynthesis pathways to modulate reproductive health.
Product promise
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