MW 214.23 Da, Purity >98%. Broad spectrum cytoprotective agent. Inactive prodrug of WR-1065. In vitro effects include p53 activation and indirect activation of proteins, including Bcl-2 and HIF-1α, involved in DNA repair and apoptosis. .
Images
Key facts
- CAS number
- 20537-88-6
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 214.23 Da
- Molecular formula
- C5H15N2O3PS
- PubChem identifier
- 2141
- Nature
- Synthetic
Target data
Alternative names
AChR, CHRM1, Cholinergic receptor muscarinic 1, D(2) dopamine receptor, D(3) dopamine receptor, Dopamine D2 receptor, Dopamine D3 receptor, HM1, Muscarinic acetylcholine receptor M1
Recommended products
MW 214.23 Da, Purity >98%. Broad spectrum cytoprotective agent. Inactive prodrug of WR-1065. In vitro effects include p53 activation and indirect activation of proteins, including Bcl-2 and HIF-1α, involved in DNA repair and apoptosis. .
Key facts
- CAS number
- 20537-88-6
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 214.23 Da
- Molecular formula
- C5H15N2O3PS
- PubChem identifier
- 2141
- Nature
- Synthetic
- Solubility
Soluble in water to 100 mM.
- Biochemical name
- Amifostine
- Biological description
Broad spectrum cytoprotective agent. Inactive prodrug of WR-1065. In vitro effects include p53 activation and indirect activation of proteins, including Bcl-2 and HIF-1α, involved in DNA repair and apoptosis.
- Canonical SMILES
- C(CN)CNCCSP(=O)(O)O
- InChI
- InChI=1S/C5H15N2O3PS/c6-2-1-3-7-4-5-12-11(8,9)10/h7H,1-6H2,(H2,8,9,10)
- InChIKey
- JKOQGQFVAUAYPM-UHFFFAOYSA-N
- IUPAC name
- 2-(3-aminopropylamino)ethylsulfanylphosphonic acid
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Muscarinic Acetylcholine Receptor 1 (CHRM1) and Dopamine Receptors D2 and D3 play significant roles in neurotransmission. CHRM1 also known as M1 receptor is a G protein-coupled receptor with a mass of approximately 51 kDa. It is primarily found in the central nervous system particularly regions like the cerebral cortex and hippocampus. Dopamine Receptors D2 and D3 both belonging to the dopamine receptor family are expressed in brain regions like the striatum and frontal cortex. These receptors modulate neurotransmitter activity by interacting with their ligands acetylcholine and dopamine respectively.
- Biological function summary
These receptors are involved in cognitive functions and motor control. CHRM1 participates in mediating cholinergic signals that influence learning and memory. It functions as part of a complex with other muscarinic receptors affecting neuronal excitability and signal transduction. Dopamine Receptors D2 and D3 regulate dopaminergic pathways important for movement and reward processing contributing to controlling behavior through dopaminergic synapses.
- Pathways
Muscarinic Acetylcholine Receptor 1 integrates into the cholinergic signaling pathway. This pathway plays a substantial role in modulating neurotransmission and synaptic plasticity. Dopamine Receptors D2 and D3 integrate into dopaminergic signaling pathways important in regulating the release of dopamine impacting mood and emotional response. These receptors share pathways with proteins such as G-proteins which are involved in signal transduction and cellular responses.
- Associated diseases and disorders
These receptors are associated with neurological and psychiatric conditions. CHRM1 is linked to Alzheimer's disease due to its involvement in cognitive function and memory. Changes in muscarinic receptor activity have been observed in patients with this condition affecting signal transmission. Dopamine Receptors D2 and D3 are implicated in diseases like schizophrenia often associated with dopamine dysregulation. Alterations in these receptors' activity influence symptoms and treatment responses. Both are connected to proteins involved in neuropsychiatric disorders such as neurotransmitter transporters and enzymes regulating neurotransmitter synthesis.
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
Chemical Structure - Amifostine, cytoprotective agent (ab141060)
2D chemical structure image of ab141060, Amifostine, cytoprotective agent
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com