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AB120281

Amiloride hydrochloride, eNaC blocker

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(4 Publications)

MW 266.09 Da, Purity >99%. Epithelial sodium channel (eNaC) blocker. At higher concentrations, blocks the Na+/H+ exchange pathway. Also blocks transient reception potential cation (TRPC6 and TRPP3) channels.

View Alternative Names

ACEE, ACES_HUMAN, AHR_HUMAN, ARACHE, Acetylcholinesterase, Ah receptor, Apoptosis related acetylcholinesterase, Aromatic hydrocarbon receptor, Aryl hydrocarbon receptor, Aryl hydrocarbon receptor precursor, BDPLT5, BXR, CAR, CAR BETA, CARA, CD 87, CD87 antigen, Car 1, Cell cycle regulated protein kinase, Class E basic helix-loop-helix protein 76, Constitutive activator of retinoid response, Constitutive active response, Constitutive androstane receptor, EC 3.4.21.73, HD 7, HD 7B, HD 9, HDAC, HDAC 7B, HDAC 9B, HDAC 9FL, HDAC9_HUMAN, HDRP, HGNC:348, Histone deacetylase 4/5 related protein, Histone deacetylase 7, Histone deacetylase 7B, Histone deacetylase 9, Histone deacetylase 9A, Histone deacetylase-related protein, KIAA0744, KPCD1_HUMAN, MB67, MEF2 interacting transcription repressor protein, MEF2-interacting transcription repressor MITR, MGC97144, MITR, MO 3, Monocyte activation antigen Mo3, N-ACHE, NF-E2-related factor 2, NF2L2_HUMAN, NR1I2_HUMAN, NR1I3_HUMAN, NRF2, Nfe2l2, Nuclear factor, Nuclear factor (erythroid derived 2) like 2, Nuclear factor erythroid 2-related factor 2, Nuclear factor erythroid derived 2 like 2, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor subfamily 1 group I member 3, ONR 1, OTTHUMP00000215173, OTTHUMP00000215174, OTTHUMP00000215175, Orphan nuclear receptor MB67, Orphan nuclear receptor NR1I3, Orphan nuclear receptor PAR 1, Orphan nuclear receptor PXR, PAR, PAR q, PKC, PKC MU, PKCM, PKD, PLAU, PLAUR, PLG, PLK, PLK1_HUMAN, PLMN_HUMAN, PRKCM, PRKD 1, PRR, Plasmin, Plasmin heavy chain A, Plasmin light chain B, Plasminogen, Plasminogen activator receptor urokinase, Plasminogen activator urokinase receptor, Polo-like kinase 1, Pregnane X receptor, Protein kinase C mu, Protein kinase C mu type, Protein kinase D, Protein kinase D1, QPD, STPK 13, SXR, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase D1, Serine/threonine-protein kinase PLK1, Steroid and xenobiotic receptor, U-plasminogen activator, UPA receptor, UPAM, UPAR_HUMAN, URK, URKR, Urinary plasminogen activator, Urinary plasminogen activator receptor, Urokinase plasminogen activator, Urokinase plasminogen activator receptor, Urokinase plasminogen activator surface receptor, Urokinase type plasminogen activator, YT, YT blood group, bHLHe76, constitutive active receptor, constitutive androstane nuclear receptor variant 2, constitutive androstane nuclear receptor variant 3, constitutive androstane nuclear receptor variant 4, constitutive androstane nuclear receptor variant 5, erythroid derived 2, like 2, nPKC-D1, nPKC-mu, nuclear factor erythroid 2 like 2, orphan nuclear hormone receptor, pregnane X nuclear receptor variant 2, u plasminogen activator receptor, u-PA, u-plasminogen activator receptor form 2, urokinase-type plasminogen activator (uPA) receptor

1 Images
Chemical Structure - Amiloride hydrochloride, eNaC blocker (AB120281)
  • Chemical Structure

Lab

Chemical Structure - Amiloride hydrochloride, eNaC blocker (AB120281)

2D chemical structure image of ab120281, Amiloride hydrochloride, eNaC blocker

Key facts

CAS number

2016-88-8

Purity

>99%

Form

Solid

form

Molecular weight

266.09 Da

Molecular formula

C<sub>6</sub>H<sub>8</sub>ClN<sub>7</sub>O.ClH

PubChem

16230

Nature

Synthetic

Solubility

Soluble in water to 10 mM (with heating)

Soluble in DMSO to 100 mM

Biochemical name

Amiloride hydrochloride

Biological description

Epithelial sodium channel (eNaC) blocker. At higher concentrations, blocks the Na+/H+ exchange pathway. Also blocks transient reception potential cation (TRPC6 and TRPP3) channels.

Canonical smiles

C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.Cl

InChi

InChI=1S/C6H8ClN7O.ClH/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;/h(H4,8,9,13)(H4,10,11,14,15);1H

InChiKey

ACHKKGDWZVCSNH-UHFFFAOYSA-N

IUPAC Name

3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide;hydrochloride

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Toxic, refer to SDS for further information.

Product protocols

Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Nature protocols 20:336-362 PubMed39215132

2024

A bioswitchable delivery system for microRNA therapeutics based on a tetrahedral DNA nanostructure.

Applications

Unspecified application

Species

Unspecified reactive species

Songhang Li,Taoran Tian,Tao Zhang,Yunfeng Lin,Xiaoxiao Cai

Biophysical journal 122:1568-1569 PubMed36948190

2023

Endocytosis Is a Key Mode of Interaction between Extracellular β-Amyloid and the Cell Membrane.

Applications

Unspecified application

Species

Unspecified reactive species

Jing-Ming Shi,Li Zhu,Xi Lan,Duan-Wei Zhao,Yong-Jun He,Zheng-Qi Sun,Di Wu,Hai-Yun Li

Biophysical journal 119:1078-1090 PubMed32857960

2020

Endocytosis Is a Key Mode of Interaction between Extracellular β-Amyloid and the Cell Membrane.

Applications

Unspecified application

Species

Unspecified reactive species

Jing-Ming Shi,Li Zhu,Xi Lan,Duan-Wei Zhao,Yong-Jun He,Zheng-Qi Sun,Di Wu,Hai-Yun Li

The Journal of neuroscience : the official journal of the Society for Neuroscience 34:11106-18 PubMed25122907

2014

Recycling endosomes undergo rapid closure of a fusion pore on exocytosis in neuronal dendrites.

Applications

Unspecified application

Species

Unspecified reactive species

Damien Jullié,Daniel Choquet,David Perrais
View all publications

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