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AB120011

AMN082 dihydrochloride, mGlu7 agonist

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(11 Publications)

MW 465.5 Da, Purity >98%. Potent, selective, orally active and brain penetrant mGlu7 receptor agonist. Potently inhibits cAMP accumulation and stimulates GTP binding (EC50 = 64-290 nM) in mGluR7 transfected cells. Selective over mGlu1, 2, 3, 4,5, 6, and 8, ionotropic receptors (up to 10 μM). Elevates plasma stress hormones *in vivo*. Induces mGlu7 receptor internalisation in dissociated hippocampal neurones.
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Chemical Structure - AMN082 dihydrochloride, mGlu7 agonist (AB120011)
  • Chemical Structure

Lab

Chemical Structure - AMN082 dihydrochloride, mGlu7 agonist (AB120011)

2D chemical structure image of ab120011, AMN082 dihydrochloride, mGlu7 agonist

Key facts

CAS number

97075-46-2

Purity

>98%

Form

Solid

form

Molecular weight

465.5 Da

Molecular formula

C<sub>2</sub><sub>8</sub>H<sub>3</sub><sub>0</sub>Cl<sub>2</sub>N<sub>2</sub>

PubChem

11698390

Nature

Synthetic

Solubility

Soluble in water to 5 mM

Soluble in ethanol to 1 mM

Soluble in DMSO to 100 mM

Biochemical name

Amn082 dihydrochloride

Biological description

Potent, selective, orally active and brain penetrant mGlu7 receptor agonist. Potently inhibits cAMP accumulation and stimulates GTP binding (EC50 = 64-290 nM) in mGluR7 transfected cells. Selective over mGlu1, 2, 3, 4,5, 6, and 8, ionotropic receptors (up to 10 μM). Elevates plasma stress hormones *in vivo*. Induces mGlu7 receptor internalisation in dissociated hippocampal neurones.

Canonical smiles

C1=CC=C(C=C1)C(C2=CC=CC=C2)NCCNC(C3=CC=CC=C3)C4=CC=CC=C4.Cl.Cl

InChi

InChI=1S/C28H28N2.2ClH/c1-5-13-23(14-6-1)27(24-15-7-2-8-16-24)29-21-22-30-28(25-17-9-3-10-18-25)26-19-11-4-12-20-26;;/h1-20,27-30H,21-22H2;2*1H

InChiKey

YRQCDCNQANSUPB-UHFFFAOYSA-N

IUPAC Name

N,N'-dibenzhydrylethane-1,2-diamine;dihydrochloride

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Complementary Products

Biochemicals

AB120003

D-AP5, NMDA glutamate site antagonist

Chemical Structure - D-AP5, NMDA glutamate site antagonist (AB120003)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
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Primary Antibodies

AB302531

Anti-Metabotropic Glutamate Receptor 7/MGLUR7 antibody [EPR24530-11] (BSA and Azide free)

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Metabotropic Glutamate Receptor 7/MGLUR7 antibody [EPR24530-11] (BSA and Azide free) (AB302531)

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  • 0
Primary Antibodies

AB205921

Anti-PD-L1 antibody [28-8]

BOND RX™ Validated|20ul selling size|Recombinant|KO Validated|Advanced Validation|RabMAb

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PD-L1 antibody [28-8] (AB205921)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (11)

Recent publications for all applications. Explore the full list and refine your search

Brain research bulletin 140:28-33 PubMed29605484

2018

AMN082-a metabotropic glutamate receptor type 7 allosteric agonist in the NAc facilitates extinction and inhibits the reinstatement of morphine-induced conditioned place preference in male rats.

Applications

Unspecified application

Species

Unspecified reactive species

Mahsaneh Vatankhah,Abdolrahman Sarihi,Alireza Komaki,Siamak Shahidi,Abbas Haghparast

Frontiers in cellular neuroscience 9:345 PubMed26388733

2015

Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals.

Applications

Unspecified application

Species

Unspecified reactive species

Luca Bragina,Tiziana Bonifacino,Silvia Bassi,Marco Milanese,Giambattista Bonanno,Fiorenzo Conti

Behavioural brain research 253:9-16 PubMed23827202

2013

Effects of group II and III metabotropic glutamate receptor ligands on conditioned taste aversion learning.

Applications

Unspecified application

Species

Unspecified reactive species

D Klakotskaia,A K Ramsey,S W Fowler,P Serfozo,A Simonyi,T R Schachtman

Psychopharmacology 220:481-94 PubMed21952670

2011

Opposing efficacy of group III mGlu receptor activators, LSP1-2111 and AMN082, in animal models of positive symptoms of schizophrenia.

Applications

Unspecified application

Species

Unspecified reactive species

Joanna M Wierońska,Katarzyna Stachowicz,Francine Acher,Tomasz Lech,Andrzej Pilc

The Journal of pharmacology and experimental thera 338:345-52 PubMed21508084

2011

The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise?

Applications

Unspecified application

Species

Unspecified reactive species

Stacey J Sukoff Rizzo,Sarah K Leonard,Adam Gilbert,Paul Dollings,Deborah L Smith,Mei-Yi Zhang,Li Di,Brian J Platt,Sarah Neal,Jason M Dwyer,Corey N Bender,Jean Zhang,Tim Lock,Dianne Kowal,Angela Kramer,Andrew Randall,Christine Huselton,Karthick Vishwanathan,Susanna Y Tse,John Butera,Robert H Ring,Sharon Rosenzweig-Lipson,Zoë A Hughes,John Dunlop

The Journal of pharmacology and experimental therapeutics 334:1066-74 PubMed20562216

2010

The antidepressant-like action of metabotropic glutamate 7 receptor agonist N,N'-bis(diphenylmethyl)-1,2-ethanediamine (AMN082) is serotonin-dependent.

Applications

Unspecified application

Species

Unspecified reactive species

Agnieszka Pałucha-Poniewiera,Piotr Brański,Tomasz Lenda,Andrzej Pilc

British journal of pharmacology 160:367-75 PubMed20423346

2010

A novel role for the metabotropic glutamate receptor-7: modulation of faecal water content and colonic electrolyte transport in the mouse.

Applications

Unspecified application

Species

Unspecified reactive species

M Julio-Pieper,N P Hyland,J A Bravo,T G Dinan,J F Cryan

Behavioural pharmacology 20:596-604 PubMed19667973

2009

The selective metabotropic glutamate receptor 7 allosteric agonist AMN082 inhibits inflammatory pain-induced and incision-induced hypersensitivity in rat.

Applications

Unspecified application

Species

Unspecified reactive species

Sharron Dolan,Mark D Gunn,Laura Biddlestone,Andrea M Nolan

Physiological research 57:969-972 PubMed19154087

2009

AMN 082, an agonist of mGluR7, exhibits mixed anti- and proconvulsant effects in developing rats.

Applications

Unspecified application

Species

Unspecified reactive species

P Mares

Neuropharmacology 54:804-14 PubMed18255102

2008

Group III mGluR regulation of synaptic transmission at the SC-CA1 synapse is developmentally regulated.

Applications

Unspecified application

Species

Unspecified reactive species

Jennifer E Ayala,Colleen M Niswender,Qingwei Luo,Jessica L Banko,P Jeffrey Conn
View all publications
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