JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB141200

Ampicillin trihydrate, beta-lactam antibiotic

Be the first to review this product! Submit a review

|

(0 Publication)

MW 349.4 Da, Purity >98%. β-lactam antibiotic (MIC50 = 3.12 μg/ml). Competitively inhibits transpeptidase causing cell wall disruption to Gram-positive and Gram-negative bacteria. Active in vitro and in vivo.

View Alternative Names

DINB protein, DINB1, DINP, DNA damage inducible protein b, DNA polymerase eta, DNA polymerase iota, DNA polymerase kappa, DinB homolog 1 (E. coli), Eta 2, FLJ16395, FLJ21978, POLH_HUMAN, POLI_HUMAN, POLK_HUMAN, POLQ, Polymerase (DNA directed) iota, Polymerase (DNA directed) kappa, RAD 30B, RAD30, RAD30 homolog A, RAD30 homolog B, RAD30, S. cerevisiae, homolog of, RAD30A, RAD3OB, XP V, Xeroderma pigmentosum variant type protein, polymerase DNA directed eta, polymerase, DNA, kappa

1 Images
Chemical Structure - Ampicillin trihydrate, beta-lactam antibiotic (AB141200)
  • Chemical Structure

Lab

Chemical Structure - Ampicillin trihydrate, beta-lactam antibiotic (AB141200)

2D chemical structure image of ab141200, Ampicillin trihydrate, beta-lactam antibiotic

Key facts

CAS number

69-53-4

Purity

>98%

Form

Solid

form

Source

Zea sp.

Molecular weight

349.4 Da

Molecular formula

C<sub>1</sub><sub>6</sub>H<sub>1</sub><sub>9</sub>N<sub>3</sub>O<sub>4</sub>S

PubChem

6249

Nature

Native

Solubility

Soluble in DMSO to 100 mM

Soluble in water to 10 mM

Biochemical name

Ampicillin

Biological description

β-lactam antibiotic (MIC50 = 3.12 μg/ml). Competitively inhibits transpeptidase causing cell wall disruption to Gram-positive and Gram-negative bacteria. Active in vitro and in vivo.

Canonical smiles

CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)N)C(=O)O)C

Isomeric smiles

CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=CC=C3)N)C(=O)O)C

InChi

InChI=1S/C16H19N3O4S/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23)/t9-,10-,11+,14-/m1/s1

InChiKey

AVKUERGKIZMTKX-NJBDSQKTSA-N

IUPAC Name

(2S,5R,6R)-6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DNA Polymerase iota (Pol ι) DNA Polymerase kappa (POLK) and DNA Polymerase eta (Pol η) are specialized Y-family DNA polymerases. These enzymes play roles in DNA translesion synthesis allowing DNA replication across damaged templates. DNA Polymerase eta for instance may weigh around 80 kDa. These enzymes are expressed in a variety of tissues with higher activity in proliferative cells. Their expression and activity may vary depending on the cell cycle and specific cellular needs for DNA repair.
Biological function summary

These DNA polymerases provide a mechanism for replicative bypass of DNA lesions ensuring continuity of DNA replication. They do not work in isolation but cooperate within the DNA damage tolerance pathways. Pol η part of the error-free damage bypass pathway helps transcribe across UV-induced cyclobutane pyrimidine dimers. Pol ι and POLK participate in mutagenic bypass potentially incorporating incorrect bases opposite certain types of lesions affecting genomic stability to different extents depending on the existing lesion.

Pathways

Pol ι POLK and Pol η play essential roles in the DNA damage response and repair pathways alongside proteins like PCNA (Proliferating Cell Nuclear Antigen) and RPA (Replication Protein A). They take part in pathways such as the post-replication repair (PRR) and nucleotide excision repair (NER) pathways. Through these pathways they interact with other polymerases and accessory proteins to carry on DNA replication functions despite the presence of DNA damage.

Defects or deficiencies in DNA Polymerase eta are connected to xeroderma pigmentosum variant (XP-V) a condition causing extreme sensitivity to UV rays and heightened cancer risk. Mutations in POLK may associate with increased genomic instability contributing to cancers due to error-prone replication past DNA lesions. These polymerases interact with tumor suppressor proteins like p53 and BRCA1 in the context of the cellular response to DNA damage influencing carcinogenesis and cancer progression.
style
left-column
style
left-column

Product protocols

style
left-column
style
left-column
style
right-column

Complementary Products

Reagents, Controls & Accessories

AB146567

Ampicillin sodium (aqueous), beta-lactam antibiotic

Chemical Structure - Ampicillin sodium (aqueous), beta-lactam antibiotic (AB146567)

  • 0
  • 0
Biochemicals

AB146574

Kanamycin sulfate (aqueous), aminoglycoside antibiotic agent

Chemical Structure - Kanamycin sulfate (aqueous), aminoglycoside antibiotic agent (AB146574)

  • 0
  • 0
Multiplex Kits

AB287912

Penicillin/Streptomycin/Amphotericin B, Sterile-Filtered (100X)

  • 0
  • 0
Biochemicals

AB146573

Gentamycin sulfate (aqueous), aminoglycoside antibiotic agent

Chemical Structure - Gentamycin sulfate (aqueous), aminoglycoside antibiotic agent (AB146573)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com