MW 319.06 g/mol, Purity >99%.
Selective H2 agonist (pKi = 5.2). Weak antagonist of H3 and displays no activity at H1. Increases gastric acid secretion. Additionally increases blood pressure.
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- Proceedings of the National Academy of Sciences of the United States of America 120:e22070031202023Histamine H receptor deficit in glutamatergic neurons contributes to the pathogenesis of schizophrenia.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQianyi Ma,Lei Jiang,Han Chen,Dadao An,Yiting Ping,Yujia Wang,Haibin Dai,Xiangnan Zhang,Yi Wang,Zhong Chen,Weiwei HuPubMed 36812204
Key facts
- CAS number
- 142457-00-9
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 319.06 g/mol
- Nature
- Synthetic
Recommended products
MW 319.06 g/mol, Purity >99%.
Selective H2 agonist (pKi = 5.2). Weak antagonist of H3 and displays no activity at H1. Increases gastric acid secretion. Additionally increases blood pressure.
Key facts
- CAS number
- 142457-00-9
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 319.06 g/mol
- Nature
- Synthetic
- Solubility
Soluble in water to 100 mM.
- Biological description
Selective H2 agonist (pKi = 5.2). Weak antagonist of H3 and displays no activity at H1. Increases gastric acid secretion. Additionally increases blood pressure.
- IUPAC name
- 2-Amino-4-methyl-5-thiazoleethanamine dihydrobromide
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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2 product images
Chemical Structure - Amthamine dihydrobromide, H2 agonist (ab120778)
2D chemical structure image of ab120778, Amthamine dihydrobromide, H2 agonist
Functional Studies - Amthamine dihydrobromide, H2 agonist (ab120778)
ab78079 staining PKA R2 (phospho S96) in HepG2 cells treated with amthamine dihydrobromide (ab120778), by ICC/IF. Increase of PKA R2 (phospho S96) expression correlates with increased concentration of amthamine dihydrobromide, as described in literature.
The cells were incubated at 37°C for 60 minutes in media containing different concentrations of ab120778 (amthamine dihydrobromide) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab78079 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
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