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AB120778

Amthamine dihydrobromide, H2 agonist

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(1 Publication)

MW 319.06 g/mol, Purity >99%. Selective H2 agonist (pKi = 5.2). Weak antagonist of H3 and displays no activity at H1. Increases gastric acid secretion. Additionally increases blood pressure.
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Functional Studies - Amthamine dihydrobromide, H2 agonist (AB120778)
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Functional Studies - Amthamine dihydrobromide, H2 agonist (AB120778)

ab78079 staining PKA R2 (phospho S96) in HepG2 cells treated with amthamine dihydrobromide (ab120778), by ICC/IF. Increase of PKA R2 (phospho S96) expression correlates with increased concentration of amthamine dihydrobromide, as described in literature.
The cells were incubated at 37°C for 60 minutes in media containing different concentrations of ab120778 (amthamine dihydrobromide) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab78079 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Amthamine dihydrobromide, H2 agonist (AB120778)
  • Chemical Structure

Lab

Chemical Structure - Amthamine dihydrobromide, H2 agonist (AB120778)

2D chemical structure image of ab120778, Amthamine dihydrobromide, H2 agonist

Key facts

CAS number

142457-00-9

Purity

>99%

Form

Solid

form

Molecular weight

319.06 g/mol

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biological description

Selective H2 agonist (pKi = 5.2). Weak antagonist of H3 and displays no activity at H1. Increases gastric acid secretion. Additionally increases blood pressure.

IUPAC Name

2-Amino-4-methyl-5-thiazoleethanamine dihydrobromide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Proceedings of the National Academy of Sciences of the United States of America 120:e2207003120 PubMed36812204

2023

Histamine H receptor deficit in glutamatergic neurons contributes to the pathogenesis of schizophrenia.

Applications

Unspecified application

Species

Unspecified reactive species

Qianyi Ma,Lei Jiang,Han Chen,Dadao An,Yiting Ping,Yujia Wang,Haibin Dai,Xiangnan Zhang,Yi Wang,Zhong Chen,Weiwei Hu
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