MW 350.45 g/mol, Purity >99%. Bioactive component of Andrographis paniculata. Potent anti-inflammatory, immunosuppressant, antithrombotic and antiviral agent. Additionally displays antioxidative stress, neuroprotective and antinociceptive activities.
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Key facts
- CAS number
- 5508-58-7
- Purity
- > 99%
- Form
- Solid
- Source
- Andrographis paniculata
- Molecular weight
- 350.45 g/mol
- Molecular formula
- C20H30O5
- Nature
- Native
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MW 350.45 g/mol, Purity >99%. Bioactive component of Andrographis paniculata. Potent anti-inflammatory, immunosuppressant, antithrombotic and antiviral agent. Additionally displays antioxidative stress, neuroprotective and antinociceptive activities.
Key facts
- CAS number
- 5508-58-7
- Purity
- > 99%
- Form
- Solid
- Source
- Andrographis paniculata
- Molecular weight
- 350.45 g/mol
- Molecular formula
- C20H30O5
- Nature
- Native
- Solubility
Soluble in DMSO to 100 mM.
Soluble in ethanol to 10 mM.
- Biological description
Bioactive component of Andrographis paniculata. Potent anti-inflammatory, immunosuppressant, antithrombotic and antiviral agent. Additionally displays antioxidative stress, neuroprotective and antinociceptive activities.
- IUPAC name
- (3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-napthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- The product can be stored for up to 12 months
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2 product images
Chemical Structure - Andrographolide, anti-inflammatory agent (ab120636)
2D chemical structure image of ab120636, Andrographolide, anti-inflammatory agent
Functional Studies - Andrographolide, anti-inflammatory agent (ab120636)
MALME-3M cells were incubated at 37°C for 24h with vehicle control (0 μM) and 1 μM andrographolide (ab120636). Increased expression of p53 in MALME-3M cells correlates with an increase in andrographolide concentration, as described in literature.
Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 10 μg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 5% BSA before being incubated with Anti-p53 antibody [PAb 240] ab26 at 5 μg/ml and Anti-beta Actin antibody ab8227 at 1 μg/ml overnight at 4°C. Antibody binding was detected using an anti-mouse antibody conjugated to HRP (Goat Anti-Mouse IgG H&L (HRP) preadsorbed ab97040 ) at 1/10000 dilution and visualised using ECL development solution.
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