MW 1046.2 Da, Purity >95%. Angiotensin II (human), Vasoconstrictor peptide. Achieve your results faster with highly validated, pure and trusted compounds.
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- Frontiers in cardiovascular medicine 10:11107072023Cfa-circ002203 was upregulated in rapidly paced atria of dogs and involved in the mechanisms of atrial fibrosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWenfeng Shangguan,Tianshu Gu,Rukun Cheng,Xing Liu,Yu Liu,Shuai Miao,Weiding Wang,Fang Song,Hualing Wang,Tong Liu,Xue LiangPubMed 37593150
- Scientific reports 13:121402023Based on network pharmacology, gastrodin attenuates hypertension-induced vascular smooth muscle cell proliferation and PI3K/AKT pathway activation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAling Shen,Meizhu Wu,Farman Ali,Zhi Guo,Yi Fang,Yuting Zhou,Siyu Zhang,Wenqiang Zhang,Ying Wen,Min Yu,Jun Peng,Keji ChenPubMed 37495624
- Biomolecules 13:2023Pharmacological Inhibition of Gasdermin D Suppresses Angiotensin II-Induced Experimental Abdominal Aortic Aneurysms.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJia Guo,Jinyun Shi,Min Qin,Yan Wang,Zhidong Li,Takahiro Shoji,Toru Ikezoe,Yingbin Ge,Baohui XuPubMed 37371479
- Frontiers in pharmacology 13:10023632022Quercetin inhibits angiotensin II-induced vascular smooth muscle cell proliferation and activation of JAK2/STAT3 pathway: A target based networking pharmacology approach.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDi Wang,Farman Ali,Huixin Liu,Ying Cheng,Meizhu Wu,Muhammad Zubair Saleem,Huifang Zheng,Lihui Wei,Jiangfeng Chu,Qiurong Xie,Aling Shen,Jun PengPubMed 36324691
- Fundamental & clinical pharmacology 37:60-742022Activation of the Mas receptors by AVE0991 and MrgD receptor using alamandine to limit the deleterious effects of Ang II-induced hypertension.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLokman Hekim Tanrıverdi,Onural Özhan,Ahmet Ulu,Azibe Yıldız,Burhan Ateş,Nigar Vardı,Hacı Ahmet Acet,Hakan ParlakpinarPubMed 36117326
- Frontiers in cell and developmental biology 10:9758792022Effects of angiotensin II combined with asparaginase and dexamethasone on the femoral head in mice: A model of steroid-induced femoral head osteonecrosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJiahe Liu,Chenzhi Li,Fan Yang,Minde Li,Baolin Wu,Haojie Chen,Shaopeng Li,Xiuzhi Zhang,Jiahui Yang,Yan Xia,Mingjian Wu,Yancheng Li,Baoyi Liu,Dewei ZhaoPubMed 36187471
- Oxidative medicine and cellular longevity 2022:54905532022RIP3 Contributes to Cardiac Hypertrophy by Influencing MLKL-Mediated Calcium Influx.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHonghong Xue,Hongtao Shi,Fan Zhang,Hao Li,Chao Li,Qinghua HanPubMed 35464769
- Advances in clinical and experimental medicine : official organ Wroclaw Medical University 31:59-692021Metformin protects against abdominal aortic aneurysm by Atg7-induced autophagy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJingjing Guo,Zhu Wang,Ming Xue,Lei Mi,Mengpeng Zhao,Chao Ma,Jian Wu,Xinqiang HanPubMed 34714980
- Experimental and therapeutic medicine 21:5602021Adropin inhibits the phenotypic modulation and proliferation of vascular smooth muscle cells during neointimal hyperplasia by activating the AMPK/ACC signaling pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLi Wang,Liang-Ping Zhao,Yu-Qi Chen,Xian-Song Chang,Hui Xiong,Dai-Min Zhang,Wei-Ting Xu,Jian-Chang ChenPubMed 33850532
Key facts
- CAS number
- 4474-91-3
- Purity
- > 95%
- Form
- Solid
- Molecular weight
- 1046.2 Da
- Molecular formula
- C50H71N13O12
- PubChem identifier
- 172198
- Nature
- Synthetic
Alternative names
AG2S, AGTR1B, AGTR1_HUMAN, AGTR2_HUMAN, AT 1B, AT 1r, AT 2, AT1, AT1AR, AT1BR, AT2R1, AT2R1A, AT2R1B, ATGR 2, Agtr1a, Ang II, Angiotensin II receptor type 1, Angiotensin II type-1 receptor, Angiotensin II type-2 receptor, Angiotensin receptor 1, Angiotensin receptor 1B, Angiotensin receptor 2, At1a, HAT1R, MRX 88, Type 1B angiotensin II receptor, Type-1 angiotensin II receptor, Type-2 angiotensin II receptor, angiotensin II receptor type 2
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MW 1046.2 Da, Purity >95%. Angiotensin II (human), Vasoconstrictor peptide. Achieve your results faster with highly validated, pure and trusted compounds.
Key facts
- CAS number
- 4474-91-3
- Purity
- > 95%
- Form
- Solid
- Molecular weight
- 1046.2 Da
- Molecular formula
- C50H71N13O12
- PubChem identifier
- 172198
- Nature
- Synthetic
- Solubility
Soluble in water to 1mg/ml.
- Biochemical name
- Angiotensin II
- Canonical SMILES
- CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N
- Isomeric SMILES
- CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N
- InChI
- InChI=1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1
- InChIKey
- CZGUSIXMZVURDU-JZXHSEFVSA-N
- IUPAC name
- (3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxy-2-phenylethyl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Angiotensin II Type 1 Receptor (AGTR1) and Angiotensin II Type 2 Receptor (AGTR2) play key roles in the renin-angiotensin system which regulates blood pressure and fluid balance. AGTR1 also called AT1 receptor typically binds angiotensin II a vasoconstrictor peptide leading to vasoconstriction and an increase in blood pressure. AGTR1 has a molecular mass of approximately 41 kDa and primarily expresses in vascular smooth muscle cells the heart liver kidney and adrenal gland. AGTR2 often called AT2 receptor shares similar angiotensin II binding but can mediate effects counter to AGTR1 such as vasodilation.
- Biological function summary
These receptors function distinctly despite both interacting with the angiotensin II peptide. AGTR1 is the major mediator of the angiotensin II-induced vasoconstriction and aldosterone secretion facilitating sodium retention and influencing cardiovascular function. AGTR2 although it binds the same peptide is involved in cellular growth and differentiation displaying roles in neuroprotection and promoting vasodilation. These receptors do not form complexes like ion channels but function independently to fine-tune physiological responses.
- Pathways
AGTR1 and AGTR2 interact mainly with the renin-angiotensin-aldosterone system (RAAS) and counter-regulatory pathways like nitric oxide production. AGTR1 activation by angiotensin II influences the RAAS by triggering G-protein signaling cascades leading to the activation of phospholipase C and subsequent inositol triphosphate production. This pathway results in calcium release promoting muscle contraction. AGTR2 can modulate nitric oxide and bradykinin pathways providing vasodilation and antiproliferative effects. Proteins like angiotensin-converting enzyme (ACE) and renin help regulate these pathways through their role in converting angiotensinogen to angiotensin I then to angiotensin II.
- Associated diseases and disorders
AGTR1 and AGTR2 have implications in hypertension and heart failure. Overactivation of AGTR1 is often linked with hypertension due to its vasoconstrictive action and fluid retention. Angiotensin receptor blockers (ARBs) target AGTR1 to treat hypertension by inhibiting angiotensin II binding. AGTR2 by mediating vasodilation plays a protective role in cardiovascular diseases but can also get involved in pathological conditions like fibrosis when dysregulated. Both receptors but predominantly AGTR1 associate with conditions like diabetic nephropathy because they affect renal function. The angiotensin-converting enzyme (ACE) remains a critical upstream regulator in these disease contexts as it modulates the production of angiotensin II.
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Chemical Structure - Angiotensin II (human), Vasoconstrictor peptide (ab120183)
2D chemical structure image of ab120183, Angiotensin II (human), Vasoconstrictor peptide
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