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MW 1046.2 Da, Purity >95%. Angiotensin II (human), Vasoconstrictor peptide. Achieve your results faster with highly validated, pure and trusted compounds.


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Key facts

CAS number

4474-91-3

Purity

> 95%

Form

Solid

Molecular weight

1046.2 Da

Molecular formula

C50H71N13O12

PubChem identifier

172198

Nature

Synthetic

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Alternative names

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MW 1046.2 Da, Purity >95%. Angiotensin II (human), Vasoconstrictor peptide. Achieve your results faster with highly validated, pure and trusted compounds.

Alternative names

Key facts

Purity

> 95%

PubChem identifier

172198

Biochemical name

Angiotensin II

Canonical SMILES

CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N

Isomeric SMILES

CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N

InChI

InChI=1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1

InChIKey

CZGUSIXMZVURDU-JZXHSEFVSA-N

IUPAC name

(3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxy-2-phenylethyl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate long-term storage conditions

-20°C

Storage information

Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary info

Biological summary

These receptors function distinctly despite both interacting with the angiotensin II peptide. AGTR1 is the major mediator of the angiotensin II-induced vasoconstriction and aldosterone secretion facilitating sodium retention and influencing cardiovascular function. AGTR2 although it binds the same peptide is involved in cellular growth and differentiation displaying roles in neuroprotection and promoting vasodilation. These receptors do not form complexes like ion channels but function independently to fine-tune physiological responses.

Mechanical summary

Angiotensin II Type 1 Receptor (AGTR1) and Angiotensin II Type 2 Receptor (AGTR2) play key roles in the renin-angiotensin system which regulates blood pressure and fluid balance. AGTR1 also called AT1 receptor typically binds angiotensin II a vasoconstrictor peptide leading to vasoconstriction and an increase in blood pressure. AGTR1 has a molecular mass of approximately 41 kDa and primarily expresses in vascular smooth muscle cells the heart liver kidney and adrenal gland. AGTR2 often called AT2 receptor shares similar angiotensin II binding but can mediate effects counter to AGTR1 such as vasodilation.

Pathway

AGTR1 and AGTR2 interact mainly with the renin-angiotensin-aldosterone system (RAAS) and counter-regulatory pathways like nitric oxide production. AGTR1 activation by angiotensin II influences the RAAS by triggering G-protein signaling cascades leading to the activation of phospholipase C and subsequent inositol triphosphate production. This pathway results in calcium release promoting muscle contraction. AGTR2 can modulate nitric oxide and bradykinin pathways providing vasodilation and antiproliferative effects. Proteins like angiotensin-converting enzyme (ACE) and renin help regulate these pathways through their role in converting angiotensinogen to angiotensin I then to angiotensin II.

Disease

AGTR1 and AGTR2 have implications in hypertension and heart failure. Overactivation of AGTR1 is often linked with hypertension due to its vasoconstrictive action and fluid retention. Angiotensin receptor blockers (ARBs) target AGTR1 to treat hypertension by inhibiting angiotensin II binding. AGTR2 by mediating vasodilation plays a protective role in cardiovascular diseases but can also get involved in pathological conditions like fibrosis when dysregulated. Both receptors but predominantly AGTR1 associate with conditions like diabetic nephropathy because they affect renal function. The angiotensin-converting enzyme (ACE) remains a critical upstream regulator in these disease contexts as it modulates the production of angiotensin II.

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1 product image

  • Chemical Structure - Angiotensin II (human), Vasoconstrictor peptide (ab120183), expandable thumbnail

    Chemical Structure - Angiotensin II (human), Vasoconstrictor peptide (ab120183)

    2D chemical structure image of ab120183, Angiotensin II (human), Vasoconstrictor peptide

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Product protocols

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