MW 219.24 Da, Purity >99%. Nootropic, positive allosteric modulator of AMPA receptors. Slows AMPA receptor deactivation and desensitisation. Antidpressant and anxiolytic in vivo. Also available in Kit: Ionotropic agonists (ab120323).
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Key facts
- CAS number
- 72432-10-1
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 219.24 Da
- Molecular formula
- C12H13NO3
- PubChem identifier
- 2196
- Nature
- Synthetic
Target data
Alternative names
(R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, AMPA 1, AMPA-selective glutamate receptor 1, CP2C9_HUMAN, CPC12, CPC8, CPC9, CPCJ, CYP2C, CYP2C10, CYPIIC9, Cytochrome P-450MP, Cytochrome P450 2C9, Cytochrome P450 MP-4, Cytochrome P450 MP-8, Cytochrome P450 PB-1, Cytochrome P450, family 2, subfamily C, polypeptide 9, GLUH1, GRIA1_HUMAN, GluA1, GluR-1, GluR-A, GluR-K1, Glutamate receptor 1, Glutamate receptor ionotropic, Glutamate receptor ionotropic AMPA 1, HBGR1, MGC133252, MGC149605, MGC88320, Microsomal monooxygenase, OTTHUMP00000020135, OTTHUMP00000160643, OTTHUMP00000165781, OTTHUMP00000224241, OTTHUMP00000224242, OTTHUMP00000224243, P450 MP, P450 PB 1, P450C2C, P450IIC19, P450IIC9, S-mephenytoin 4-hydroxylase, Xenobiotic monooxygenase, cytochrome P-450 S-mephenytoin 4-hydroxylase, flavoprotein-linked monooxygenase
Recommended products
MW 219.24 Da, Purity >99%. Nootropic, positive allosteric modulator of AMPA receptors. Slows AMPA receptor deactivation and desensitisation. Antidpressant and anxiolytic in vivo. Also available in Kit: Ionotropic agonists (ab120323).
Key facts
- CAS number
- 72432-10-1
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 219.24 Da
- Molecular formula
- C12H13NO3
- PubChem identifier
- 2196
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
Soluble in ethanol to 25 mM.
- Biochemical name
- Aniracetam
- Biological description
Nootropic, positive allosteric modulator of AMPA receptors. Slows AMPA receptor deactivation and desensitisation. Antidpressant and anxiolytic in vivo. Also available in Kit: Ionotropic agonists (ab120323).
- Canonical SMILES
- COC1=CC=C(C=C1)C(=O)N2CCCC2=O
- InChI
- InChI=1S/C12H13NO3/c1-16-10-6-4-9(5-7-10)12(15)13-8-2-3-11(13)14/h4-7H,2-3,8H2,1H3
- InChIKey
- ZXNRTKGTQJPIJK-UHFFFAOYSA-N
- IUPAC name
- 1-(4-methoxybenzoyl)pyrrolidin-2-one
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- The product can be stored for up to 12 months
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Glutamate Receptor 1 (GRIA1) also known as AMPA receptor is a subunit of ionotropic glutamate receptors with a mass of about 106 kDa. This protein is mainly expressed in the central nervous system especially in the brain cortex. GRIA1 plays a role in excitatory neurotransmission by controlling the flow of ions through the cell membrane important for synaptic plasticity and neuron communication. This receptor forms tetrameric complexes facilitating rapid synaptic transmission by mediating the influx of calcium and sodium ions upon glutamate binding.
- Biological function summary
GRIA1 influences cellular signaling through synaptic strength modulation and neuroplasticity important for learning and memory. It forms a part of the larger AMPA receptor complex which includes other subunits like Glutamate Receptor 2 (GRIA2). AMPA receptors' activity may modulate neuronal circuit function and interacts functionally with NMDA receptors to allow calcium permeability upon synaptic excitation. The dynamic expression and function of GRIA1 contribute to maintaining synaptic homeostasis and adaptability.
- Pathways
GRIA1 is active in the glutamatergic synapse pathway and plays a significant role in long-term potentiation (LTP) an essential mechanism underlying learning and memory. The receptor’s function connects with NMDA receptors and other signaling proteins such as CaMKII which further propagate intracellular signaling cascades. GRIA1's involvement in these pathways highlights its coordination with other proteins to promote proper synaptic function and neural plasticity.
- Associated diseases and disorders
GRIA1 shows associations with neurological conditions such as epilepsy and schizophrenia. Altered expression or function of GRIA1 can disrupt normal ion flow contributing to hyperexcitability and cognitive dysfunctions. This receptor interacts with proteins like PSD-95 part of synaptic scaffolding which may exhibit deviating expression profiles in disorders. Understanding GRIA1’s role and how it relates to other proteins can advance therapeutic strategies for neurological diseases.
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Chemical Structure - Aniracetam, AMPA receptor poteniator (ab120316)
2D chemical structure image of ab120316, Aniracetam, AMPA receptor poteniator
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