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AB282442

Apatinib

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(1 Publication)

MW 441.9 Da. Potent and selective inhibitor of VEGFR2, IC50 = 1 nm. Orally bioavailable. Achieve your results faster with highly validated, pure and trusted compounds.

Key facts

Form

Solid

form

Molecular weight

441.9 Da

Molecular formula

C<sub>2</sub><sub>4</sub>H<sub>2</sub><sub>4</sub>ClNO<sub>5</sub>

PubChem

1315474

Nature

Synthetic

Solubility

Soluble in DMSO ?100 mM

Biochemical name

4-[(2-chlorophenoxy)methyl]-N-(3,4,5-trimethoxybenzyl)benzamide

Biological description

Potent and selective inhibitor of VEGFR2, IC50 = 1 nm. Orally bioavailable.

Canonical smiles

COC1=CC(=CC(=C1OC)OC)CNC(=O)C2=CC=C(C=C2)COC3=CC=CC=C3Cl

InChi

InChI=1S/C24H24ClNO5/c1-28-21-12-17(13-22(29-2)23(21)30-3)14-26-24(27)18-10-8-16(9-11-18)15-31-20-7-5-4-6-19(20)25/h4-13H,14-15H2,1-3H3,(H,26,27)

InChiKey

XLIUTITZOISOFE-UHFFFAOYSA-N

IUPAC Name

4-[(2-chlorophenoxy)methyl]-N-[(3,4,5-trimethoxyphenyl)methyl]benzamide

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Product details

For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer science 102:1374-80 PubMed21443688

2011

YN968D1 is a novel and selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase with potent activity in vitro and in vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Shu Tian,Haitian Quan,Chengying Xie,Haiyi Guo,Fangfang Lü,Yongping Xu,Jin Li,Liguang Lou
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