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AB141849

APETx2, ASIC3 channel blocker

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(1 Publication)

MW 4561.05 g/mol, Purity >98%. Selective, reversible ASIC3 channel blocker (IC50 = 63 nM). Inhibits heteromeric ASIC2b and ASIC3 currents (IC50 = 117 nM) and NaV1.8 channels (IC50 = 2.6 μM). Shows analgesic effects in vivo.
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Functional Studies - APETx2, ASIC3 channel blocker (AB141849)
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Functional Studies - APETx2, ASIC3 channel blocker (AB141849)

APETx2 blocks inward currents of ASIC3 channels expressed in Xenopus oocytes. Membrane potential was held at 5 mV and whole cell current was continuously recorded. ASIC3 currents were elicited by rapid exposure to pH 5 in physiological solution every 20 sec. 1 µM APETx2 (ab141849) was introduced into the bath via perfusion, resulting in a reversible inhibition of the pH dependent inward transients.

Chemical Structure - APETx2, ASIC3 channel blocker (AB141849)
  • Chemical Structure

Lab

Chemical Structure - APETx2, ASIC3 channel blocker (AB141849)

2D chemical structure image of ab141849, APETx2, ASIC3 channel blocker

Key facts

CAS number

713544-47-9

Purity

>98%

Form

Solid

form

Source

Anthopleura elegantissima

Molecular weight

4561.05 g/mol

Nature

Native

Solubility

Soluble in water to 1 mg/ml

Biological description

Selective, reversible ASIC3 channel blocker (IC50 = 63 nM). Inhibits heteromeric ASIC2b and ASIC3 currents (IC50 = 117 nM) and NaV1.8 channels (IC50 = 2.6 μM). Shows analgesic effects in vivo.

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of nanobiotechnology 22:556 PubMed39267105

2024

A novel spherical GelMA-HAMA hydrogel encapsulating APET×2 polypeptide and CFIm25-targeting sgRNA for immune microenvironment modulation and nucleus pulposus regeneration in intervertebral discs.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Jun Yu,Yuan-Ting Zhao,Haimiti Abudouaini,Peng Zou,Tian-Qi Li,Xiao-Fan Bai,Shan-Xi Wang,Jian-Bin Guan,Meng-Wei Li,Xiao-Dong Wang,Ying-Guang Wang,Ding-Jun Hao
View all publications
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