MW 4561.05 g/mol, Purity >98%. Selective, reversible ASIC3 channel blocker (IC50 = 63 nM). Inhibits heteromeric ASIC2b and ASIC3 currents (IC50 = 117 nM) and NaV1.8 channels (IC50 = 2.6 μM). Shows analgesic effects in vivo.
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Key facts
- CAS number
- 713544-47-9
- Purity
- > 98%
- Form
- Solid
- Source
- Anthopleura elegantissima
- Molecular weight
- 4561.05 g/mol
- Nature
- Native
Recommended products
MW 4561.05 g/mol, Purity >98%. Selective, reversible ASIC3 channel blocker (IC50 = 63 nM). Inhibits heteromeric ASIC2b and ASIC3 currents (IC50 = 117 nM) and NaV1.8 channels (IC50 = 2.6 μM). Shows analgesic effects in vivo.
Key facts
- CAS number
- 713544-47-9
- Purity
- > 98%
- Form
- Solid
- Source
- Anthopleura elegantissima
- Molecular weight
- 4561.05 g/mol
- Nature
- Native
- Solubility
Soluble in water to 1 mg/ml.
- Biological description
Selective, reversible ASIC3 channel blocker (IC50 = 63 nM). Inhibits heteromeric ASIC2b and ASIC3 currents (IC50 = 117 nM) and NaV1.8 channels (IC50 = 2.6 μM). Shows analgesic effects in vivo.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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2 product images
Chemical Structure - APETx2, ASIC3 channel blocker (ab141849)
2D chemical structure image of ab141849, APETx2, ASIC3 channel blocker
Functional Studies - APETx2, ASIC3 channel blocker (ab141849)
APETx2 blocks inward currents of ASIC3 channels expressed in Xenopus oocytes. Membrane potential was held at 5 mV and whole cell current was continuously recorded. ASIC3 currents were elicited by rapid exposure to pH 5 in physiological solution every 20 sec. 1 µM APETx2 (ab141849) was introduced into the bath via perfusion, resulting in a reversible inhibition of the pH dependent inward transients.
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