MW 623.8 Da, Purity >95%. Potent histone deacetylase inhibitor (IC50 = 0.7 nM). Inhibits cancer cell proliferation via induction of p21WAF1/Cip1 and gelsolin. Active in vitro and in vivo. Cell-permeable.
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AHO3, Antigen NY-CO-9, BDMR, CD142, CD142 antigen, CDA07, CDLS5, CPBHM, CTG 26, CTG repeat protein 26, Coagulation factor III, Coagulation factor III (thromboplastin tissue factor), D10Wsu179e, DKFZP761B039, DKFZp686H12203, EC 3.5.1.98, F3, FLJ16239, FLJ17960, FLJ22237, GON 10, HA6116, HD 10, HD 11, HD 2, HD 4, HD 6, HD 7, HD 7B, HD 8, HD 9, HD1, HD3, HD5, HDA10_HUMAN, HDA11_HUMAN, HDAC, HDAC 11, HDAC 7B, HDAC 9B, HDAC 9FL, HDAC A, HDAC1_HUMAN, HDAC2_HUMAN, HDAC3_HUMAN, HDAC4_HUMAN, HDAC5_HUMAN, HDAC6_HUMAN, HDAC8_HUMAN, HDAC9_HUMAN, HDACL-1, HDRP, Histone Deacetylase A, Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 11, Histone deacetylase 2, Histone deacetylase 2 (HD2), Histone deacetylase 3, Histone deacetylase 4, Histone deacetylase 4/5 related protein, Histone deacetylase 5, Histone deacetylase 6, Histone deacetylase 6 (HD6), Histone deacetylase 7, Histone deacetylase 7B, Histone deacetylase 8, Histone deacetylase 9, Histone deacetylase 9A, Histone deacetylase like 1, Histone deacetylase-related protein, JM 21, KIAA0288, KIAA0744, KIAA0901, MEF2 interacting transcription repressor protein, MEF2-interacting transcription repressor MITR, MGC149722, MITR, MRXS6, NCOR2_HUMAN, NY CO 9, Nuclear Receptor Co-Repressor 2, OTTHUMP00000017046, OTTHUMP00000028555, OTTHUMP00000032398, OTTHUMP00000197663, OTTHUMP00000227077, OTTHUMP00000227078, PPP1R90, Protein phosphatase 1 regulatory subunit 90, RPD 3, RPD3-2, RPD3L1, Reduced potassium dependency yeast homolog like 1, SMAP 270, SMAP45, SMRT, SMRTE, SMRTE tau, Silencing Mediator for Retanoid and Thyroid Hormone Receptors, Silencing mediator of retinoic acid and thyroid hormone receptor, T3 receptor-associating factor, TFA, TF_HUMAN, TNRC 14, TRAC 1, Thromboplastin, Thyroid retinoic acid receptor associated corepressor, Thyroid-, Tissue factor, WTS, YAF1, YY1 associated factor 1, YY1 transcription factor binding protein, Yy1bp, retinoic-acid-receptor-associated corepressor, transcriptional regulator homolog RPD3
- Chemical Structure
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Chemical Structure - Apicidin, HDAC inhibitor (AB142060)
2D chemical structure image of ab142060, Apicidin, HDAC inhibitor
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Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Histone deacetylases HDAC1 HDAC2 HDAC3 HDAC4 and HDAC5 participate in transcriptional repression when part of larger multiprotein complexes. HDAC9 is another member that shares similar roles. These complexes often include NCOR2/SMRT which acts as a co-repressor. By altering chromatin conformation they play a vital role in development differentiation and cell cycle regulation. Their activity is modulated by HDAC inhibitors like trichostatin A and valproic acid which are used in research and therapeutics for epigenetic modulation.
Pathways
The HDAC family members are central in pathways such as the cell cycle regulation pathway and the Wnt signaling pathway. They interact with proteins like histone acetyltransferases (HATs) balancing acetylation states and controlling gene expression dynamics. In the Wnt pathway changes in acetylation states influence transcriptional outcomes that are vital for developmental processes and oncogenic transformations.
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