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AB120141

Apigenin, Anticancer agent

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(1 Publication)

MW 270.24 Da, Purity >98%. Plant flavone. Antioxidant, anti-inflammatory and anticancer properties. Effects a wide range of molecular targets including caspases, fatty acid synthase, topoisomerase and nuclear factor-κB.
2 Images
Functional Studies - Apigenin, Anticancer agent (AB120141)
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PubMed

Functional Studies - Apigenin, Anticancer agent (AB120141)

(A-D). The release of cytokines as assessed using Human Cytokine Array C1000 membranes from MDA-MB-231 cells ± TNFα ± Apigenin. [A] Ctrls, [B] TNFα-treated (40ng/mL) [C] Apigenin (40μM) and [D] TNFα-treated (40ng/mL) + Apigenin (40μM) co-treated cells.

Bauer et al PLoS One. 2017 Apr 25;12(4):e0175558. doi: 10.1371/journal.pone.0175558. eCollection 2017. Fig 2. Reproduced under the Creative Commons license https://creativecommons.org/publicdomain/zero/1.0/

Chemical Structure - Apigenin, Anticancer agent (AB120141)
  • Chemical Structure

Lab

Chemical Structure - Apigenin, Anticancer agent (AB120141)

2D chemical structure image of ab120141, Apigenin, Anticancer agent

Key facts

CAS number

520-36-5

Purity

>98%

Form

Solid

form

Molecular weight

270.24 Da

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>1</sub><sub>0</sub>O<sub>5</sub>

PubChem

5280443

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

Apigenin

Biological description

Plant flavone. Antioxidant, anti-inflammatory and anticancer properties. Effects a wide range of molecular targets including caspases, fatty acid synthase, topoisomerase and nuclear factor-κB.

Canonical smiles

C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O

InChi

InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H

InChiKey

KZNIFHPLKGYRTM-UHFFFAOYSA-N

IUPAC Name

5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

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PloS one 12:e0175558 PubMed28441391

2017

Apigenin inhibits TNFα/IL-1α-induced CCL2 release through IKBK-epsilon signaling in MDA-MB-231 human breast cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

David Bauer,Natalie Redmon,Elizabeth Mazzio,Karam F Soliman
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