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AB285379

Apremilast

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MW 460.5 Da, Purity >98%. Ppotent PDE4 (phosphodiesterase 4) inhibitor (IC₅₀ = 74 nM). It reduces TNF-α production in human synovial cells and significantly suppresses experimental arthritis.

Key facts

CAS number

608141-41-9

Purity

>98%

Form

Solid

form

Molecular weight

460.5 Da

Molecular formula

C<sub>2</sub><sub>2</sub>H<sub>2</sub><sub>4</sub>N<sub>2</sub>O<sub>7</sub>S

PubChem

11561674

Nature

Synthetic

Solubility

DMSO (>80 mg/ml)

Biochemical name

Apremilast

Biological description

Ppotent PDE4 (phosphodiesterase 4) inhibitor (IC₅₀ = 74 nM). It reduces TNF-α production in human synovial cells and significantly suppresses experimental arthritis.

Canonical smiles

CCOC1=C(C=CC(=C1)C(CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC

Isomeric smiles

CCOC1=C(C=CC(=C1)[C@@H](CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC

InChi

InChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1

InChiKey

IMOZEMNVLZVGJZ-QGZVFWFLSA-N

IUPAC Name

N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-1,3-dioxoisoindol-4-yl]acetamide

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 2352 Apremilast. 2352-25 is the same size as the 25 mg size of ab285379.

Protect from air and moisture.

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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this is air sensitive and impurities can occur as a result of air oxidation
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Product protocols

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Product promise

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