AR-R 17779 hydrochloride, alpha7 nAChR agonist

Key facts

CAS number

178419-42-6

Form

Solid

form

Molecular weight

218.68 Da

Molecular formula

C₉H₁₅ClN₂O₂

PubChem

9859263

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

Ar-r 17779 hydrochloride

Biological description

Potent, selective α7 nAChR agonist (EC₅₀ = 420 nM). Shows excitatory central effects in vivo. Blood-brain barrier permeable.

Canonical smiles

C1CN2CCC1C3(C2)CNC(=O)O3.Cl

Isomeric smiles

C1CN2CCC1[C@@]3(C2)CNC(=O)O3.Cl

InChi

InChI=1S/C9H14N2O2.ClH/c12-8-10-5-9(13-8)6-11-3-1-7(9)2-4-11;/h7H,1-6H2,(H,10,12);1H/t9-;/m0./s1

InChiKey

XGLBLUBBDSJBIU-FVGYRXGTSA-N

IUPAC Name

(5S)-spiro[1,3-oxazolidine-5,3'-1-azabicyclo[2.2.2]octane]-2-one;hydrochloride