Skip to main content

MW 236.11 Da, Purity >98%. Muscarinic receptor agonist (EC50 values are 7 (M1), 95 (M2), 11 (M3), 410 (M4) and 69 nM (M5)). Natural alkaloid. Induces decreased blood-brain barrier permeability.

Be the first to review this product! Submit a review

Images

Key facts

CAS number

300-08-3

Purity

> 98%

Form

Solid

Molecular weight

236.11 Da

Molecular formula

C8H14BrNO2

PubChem identifier

9301

Nature

Synthetic

Loading...
Loading...
Loading...
Loading...
Loading...
Loading...
Loading...
Loading...

Alternative names

Recommended products

  1. Loading...
  2. Loading...
  3. Loading...
  4. Loading...

MW 236.11 Da, Purity >98%. Muscarinic receptor agonist (EC50 values are 7 (M1), 95 (M2), 11 (M3), 410 (M4) and 69 nM (M5)). Natural alkaloid. Induces decreased blood-brain barrier permeability.

Alternative names

Key facts

Purity

> 98%

PubChem identifier

9301

Biochemical name

Arecoline hydrobromide

Biological description

Muscarinic receptor agonist (EC50 values are 7 (M1), 95 (M2), 11 (M3), 410 (M4) and 69 nM (M5)). Natural alkaloid. Induces decreased blood-brain barrier permeability.

Canonical SMILES

CN1CCC=C(C1)C(=O)OC.Br

InChI

InChI=1S/C8H13NO2.BrH/c1-9-5-3-4-7(6-9)8(10)11-2;/h4H,3,5-6H2,1-2H3;1H

InChIKey

AXOJRQLKMVSHHZ-UHFFFAOYSA-N

IUPAC name

methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate;hydrobromide

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate long-term storage conditions

+4°C

Storage information

Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary info

Biological function summary

TRPC4 and TRPML3 contribute to key signal transduction pathways influencing cell function. TRPC4 interacts with proteins like muscarinic receptors and involves in the regulation of vasodilation and tissue remodeling through calcium modulation. TRPML3 functions in autophagy and lysosomal trafficking forming complexes with other TRP channels. Mutations in these channels disrupt normal calcium homeostasis indicating their significance in maintaining cellular health and communication.

Activity summary

TRPC4 known as Transient Receptor Potential Canonical 4 and TRPML3 also identified as MCOLN3 are non-selective cation channels that play significant roles in calcium signaling. TRPC4 has a molecular mass of around 100 kDa and is highly expressed in endothelial and smooth muscle cells as well as in the brain. TRPML3 with a mass of roughly 65 kDa predominantly occurs in the inner ear and retina. These channels facilitate the movement of calcium ions across cellular membranes contributing to various cellular processes.

Pathways

Both TRPC4 and TRPML3 are integral to calcium signaling cascades. TRPC4 participates in the phospholipase C pathway interacting with proteins such as phosphoinositide-dependent kinase-1 and arecoline muscarinic receptor agonists to modulate vascular and cardiac functions. TRPML3 relevant in the PI3K pathway impacts lysosomal function connecting with other lysosomal proteins. These pathways illustrate how these channels orchestrate calcium's role in physiological processes.

Associated diseases and disorders

TRPC4's dysfunction associates with cardiovascular diseases particularly hypertension. Its regulatory actions on vascular tone involve interactions with nitric oxide synthase. TRPML3 relates to disorders such as hearing loss due to its role in ionic balance in the ear. Mutations in TRPML3 interact with other proteins affecting auditory hair cell function highlighting the importance of proper channel operation in disease manifestation.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • Chemical Structure - Arecoline hydrobromide, Muscarinic receptor agonist (ab141044), expandable thumbnail

    Chemical Structure - Arecoline hydrobromide, Muscarinic receptor agonist (ab141044)

    2D chemical structure image of ab141044, Arecoline hydrobromide, Muscarinic receptor agonist

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

There was a problem

We can’t download that datasheet. Please try again. If you need help, contact our Customer Services team at technical@abcam.com