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AB120898

AS-041164, PI3K gamma inhibitor

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MW 249.24 g/mol, Purity >98%. Potent PI3K inhibitor with selectivity for PI3Kγ (IC50 = 70 nM), compared to PI3Kα, β and δ (IC50 values are 240 nM, 1.45 and 1.70 μM, respectively). Shows little or n o activity against 38 other common kinases. Blocks neutrophil migration. Active in vivo.
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Chemical Structure - AS-041164, PI3K gamma inhibitor (AB120898)
  • Chemical Structure

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Chemical Structure - AS-041164, PI3K gamma inhibitor (AB120898)

2D chemical structure image of ab120898, AS-041164, PI3K gamma inhibitor

Key facts

CAS number

6318-41-8

Purity

>98%

Formulation

Constituents: 100% AS-041164

Molecular weight

249.24 g/mol

Molecular formula

C<sub>1</sub><sub>1</sub>H<sub>7</sub>NO<sub>4</sub>S

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biological description

Potent PI3K inhibitor with selectivity for PI3Kγ (IC50 = 70 nM), compared to PI3Kα, β and δ (IC50 values are 240 nM, 1.45 and 1.70 μM, respectively). Shows little or n o activity against 38 other common kinases. Blocks neutrophil migration. Active in vivo.

Isomeric smiles

O=C(/C(S1)=C/C2=CC=C3C(OCO3)=C2)NC1=O

IUPAC Name

5-[(1,3-Benzodioxol-5-yl)methylene]-2,4-thiazolidinedione

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Product protocols

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Product promise

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