AS601245, JNK inhibitor

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(2 Publications)

MW 372.4 Da, Purity >95%. Potent, selective, ATP competitive JNK inhibitor (IC₅₀ values are 150, 220 and 70 nM for hJNK1,2 and 3 respectively). Reduces cell adhesion and migration in cancer cells. Shows neuroprotective, anti-ischemic effects in vivo. Blood-brain barrier and cell-permeable.

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1810038L18Rik, AI849689, C Jun kinase 2, C-JUN kinase 1, DYRK2_HUMAN, Double stranded RNA activated protein kinase;, Dual specificity tyrosine (Y) phosphorylation regulated kinase 2, Dual specificity tyrosine-phosphorylation-regulated kinase 2, E2AK2_HUMAN, EC 2.7.11.24, EC 2.7.12.1, EIF2AK1, EIF2AK2, Eukaryotic translation initiation factor 2-alpha kinase 2, FLJ12099, FLJ21217, FLJ21365, FLJ33785, GSK-3 beta, GSK3B_HUMAN, GSK3beta isoform, Glycogen synthase kinase-3 beta, HGNC:9437, Interferon inducible elF2 alpha kinase, Interferon-induced, double-stranded RNA-activated protein kinase, Interferon-inducible RNA-dependent protein kinase, JNK, JNK 1, JNK 2, JNK-46, JNK-55, JNK1A2, JNK2 alpha, JNK2 beta, JNK21B1/2, JNK2A, JNK2B, JNK3, JNK3 alpha protein kinase, JNK3A, Jun kinase, Kid 1, Kinase induced by depolarization, MAP Kinase, MAP kinase 10, MAP kinase 8, MAP kinase 9, MAP kinase p49 3F12, MAPK 10, MAPK 8, MAPK 9, MGC126524, MGC50974, MK08_HUMAN, MK09_HUMAN, MK10_HUMAN, Mitogen-activated protein kinase 10, Mitogen-activated protein kinase 8, Mitogen-activated protein kinase 9, ONCOGENE PIM3, Oncogene PIM 1, P1/eIF-2A protein kinase, P54a, PIM, PIM1_HUMAN, PIM3_HUMAN, PPP1R83, PRKM 8, PRKM 9, PRKM10, PRKR, Pim 1 kinase, Pim 1 oncogene, Pim 3 oncogene, Pim-3 proto-oncogene, serine/threonine kinase, Protein kinase JNK1, Protein kinase Kid 1, Protein kinase RNA-activated, Protein kinase interferon inducible double stranded RNA dependent, Protein kinase, mitogen-activated, 8, Protein kinase, mitogen-activated, 9, Protein phosphatase 1 regulatory subunit 83, Proto-oncogene serine/threonine-protein kinase Pim-1, Proviral integration site 1, Proviral integration site 2, SAPK, SAPK 1, SAPK alpha, SAPK gamma, SAPK1a, SAPK1b, Serine/threonine kinase Pim 3, Serine/threonine protein kinase TIK, Serine/threonine-protein kinase GSK3B, Serine/threonine-protein kinase Pim-3, Stress activated protein kinase beta, Stress-activated protein kinase 1, Stress-activated protein kinase 1a, Stress-activated protein kinase 1b, Stress-activated protein kinase JNK1, Stress-activated protein kinase JNK2, Stress-activated protein kinase JNK3, Tyrosine protein kinase EIF2AK2, c Jun kinase 3, c-Jun N-terminal kinase 1, c-Jun N-terminal kinase 2, c-Jun N-terminal kinase 3, eIF-2A protein kinase 2, p493F12, p54 gamma, p54aSAPK, p54bSAPK, p68 kinase, pim 1 kinase 44 kDa isoform, pim 1 oncogene (proviral integration site 1), protein kinase mitogen activated 10