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AB120576

Asenapine maleate, 5-HT receptor antagonist and D2 antagonist

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MW 401.85 g/mol, Purity >99%. Novel, multiple receptor antagonist. Displays activity at 5-HT, dopamine, adrenoceptors and histamine receptors. (pKi values are 8.60 (5-HT1A), 8.40 (5-HT1B), 10.15 (5-HT2A), 9.75 (5-HT2B), 10.46 (5-HT2C), 8.84 (5-HT5A), 9.60 (5-HT6), 9.94 (5-HT7), 8.85 (D1), 8.90 (D2L), 8.84 (D2S), 9.38 (D3), 8.95 (D4), 8.93 (α1A), 8.9 (α2A), 9.49 (α2B), 8.91 (α2C), 9.00 (H1) and 8.21(H2)). Increases dopamine, norepinephrine and acetylcholine efflux. Antipsychotic in vivo.
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Chemical Structure - Asenapine maleate, 5-HT receptor antagonist and D2 antagonist (AB120576)
  • Chemical Structure

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Chemical Structure - Asenapine maleate, 5-HT receptor antagonist and D2 antagonist (AB120576)

2D chemical structure image of ab120576, Asenapine maleate, 5-HT receptor antagonist and D2 antagonist

Key facts

CAS number

85650-56-2

Purity

>99%

Form

Solid

form

Molecular weight

401.85 g/mol

Molecular formula

C<sub>1</sub><sub>7</sub>H<sub>1</sub><sub>6</sub>ClNO.C<sub>4</sub>H<sub>4</sub>O<sub>4</sub>

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

Biological description

Novel, multiple receptor antagonist. Displays activity at 5-HT, dopamine, adrenoceptors and histamine receptors. (pKi values are 8.60 (5-HT1A), 8.40 (5-HT1B), 10.15 (5-HT2A), 9.75 (5-HT2B), 10.46 (5-HT2C), 8.84 (5-HT5A), 9.60 (5-HT6), 9.94 (5-HT7), 8.85 (D1), 8.90 (D2L), 8.84 (D2S), 9.38 (D3), 8.95 (D4), 8.93 (α1A), 8.9 (α2A), 9.49 (α2B), 8.91 (α2C), 9.00 (H1) and 8.21(H2)). Increases dopamine, norepinephrine and acetylcholine efflux. Antipsychotic in vivo.

InChi

InChI=1S/C17H16ClNO.C4H4O4/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19;5-3(6)1-2-4(7)8/h2-8,14-15H,9-10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

IUPAC Name

trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole maleate

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Complementary Products

Biochemicals

AB120528

Serotonin hydrochloride (5-HT/5-Hydroxytryptamine), 5-HT receptor agonist

Chemical Structure - Serotonin hydrochloride (5-HT/5-Hydroxytryptamine), 5-HT receptor agonist (AB120528)

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Biochemicals

AB120133

Citalopram, 5-HT reuptake inhibitor

Chemical Structure - Citalopram, 5-HT reuptake inhibitor (AB120133)

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Biochemicals

AB120511

1-Phenylbiguanide, 5-HT3 receptor agonist

Chemical Structure - 1-Phenylbiguanide, 5-HT3 receptor agonist (AB120511)

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Primary Antibodies

AB317501

Anti-5HT4 Receptor antibody [EPR28675-19] - BSA and Azide free

Recombinant|RabMAb

Western blot - Anti-5HT4 Receptor antibody [EPR28675-19] - BSA and Azide free (AB317501)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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Product promise

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