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MW 458.6 Da, Purity >99%. Potent, selective histamine H1 receptor antagonist (IC50 = 4 nM) and potent hERG K+ channel blocker (IC50 =0.9 nM). Orally active. Antiallergic agent. Active *in vivo* and *in vitro*.
Alternative names=3dopamine receptor, 5 HT 2B receptor, 5 HT(2B), 5 HT1DB, 5 HT2 receptor, 5 HTT, 5 HTTLPR, 5 Hydroxytryptamine 2C receptor, 5 hydroxytryptamine (serotonin) receptor 2B, 5 hydroxytryptamine (serotonin) receptor 2B G protein coupled, 5 hydroxytryptamine (serotonin) receptor 6 G protein coupled, 5 hydroxytryptamine (serotonin) transporter, 5 hydroxytryptamine 1A receptor, 5 hydroxytryptamine 2B receptor, 5 hydroxytryptamine 6 receptor, 5 hydroxytryptamine transporter, 5-HT-1C, 5-HT-1D-beta, 5-HT-2, 5-HT-6, 5-HTR2C, 5-ht-1c receptor, 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled, 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled, 5-hydroxytryptamine 2A receptor, 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine receptor 1C, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 6, 5HT transporter, 5HT1B_HUMAN, 5HT2A_HUMAN, 5HT2B_HUMAN, 5HT2C_HUMAN, 5HT2F, 5HT6R_HUMAN, ABC 21, ABC20, ABCB1, ABCB4 protein, ACLS, ACM3_HUMAN, ACM4_HUMAN, ACM5_HUMAN, AChR, AChR M5, ADA1D_HUMAN, ADA2A_HUMAN, ADA2C_HUMAN, ADRA1A, ADRA1L1, ADRA2, ADRA2A, ADRA2L2, ADRA2R, ADRA2RL1, ADRA2RL2, ADRAR, ADRARL1, ADRARL2, ADRB2RL1, ADRBRL1, AL024364, ATP binding cassette sub family B MDR/TAP member 4, ATP binding cassette, sub family B (MDR/TAP), member 1, ATP-binding cassette sub-family B member 1, ATP-binding cassette sub-family B member 4, Acetylcholine receptor muscarinic 5, Adra 2c, Adra1d, Adrenergic alpha 1A receptor, Adrenergic alpha 1B receptor, Adrenergic alpha 1C receptor, Adrenergic alpha 1D receptor, Adrenergic alpha 2A receptor, Adrenergic alpha 2C receptor, Adrenoceptor alpha 2C, Aging-associated gene 8 protein, Alpha 2 adrenergic receptor subtype C2, Alpha 2AAR subtype C10, Alpha 2B adrenoceptor, Alpha 2B adrenoreceptor, Alpha 2C adrenergic receptor subtype C4, Alpha adrenergic receptor 1b, Alpha adrenergic receptor 1d, Alpha-1A adrenergic receptor, Alpha-1A adrenoreceptor, Alpha-1C adrenergic receptor, Alpha-1D adrenergic receptor, Alpha-1D adrenoceptor, Alpha-1D adrenoreceptor, Alpha-2 adrenergic receptor subtype C10, Alpha-2 adrenergic receptor subtype C4, Alpha-2-adrenergic receptor, renal type, Alpha-2A adrenergic receptor, Alpha-2A adrenoceptor, Alpha-2A adrenoreceptor, Alpha-2AAR, Alpha-2C adrenergic receptor, Alpha-2C adrenoceptor, Alpha-2C adrenoreceptor, Alpha-2CAR, Alpha-adrenergic receptor 1a, Alpha-adrenergic receptor 1c, Arachidonic acid epoxygenase, BPHS, mouse, homolog of, CAC1C_HUMAN, CAC1D_HUMAN, CAC1S_HUMAN, CACH 2, CACH1, CACH3, CACN 2, CACN1, CACN4, CACNA 1D, CACNL1A1, CACNL1A2, CACNL1A3, CCHL1A1, CCHL1A2, CCHL1A3, CD243, CHKM5MR, CHRM 3, CHRM1, CLCS, CP2J2_HUMAN, CPJ2, CYPIIJ2, CaV1.2, Cach1b, Calcium channel, Calcium channel L type alpha 1 polypeptide isoform 1 cardiac muscle, Calcium channel L type alpha 1 polypeptide isoform 2, Calcium channel cardic dihydropyridine sensitive alpha 1 subunit, Calcium channel neuroendocrine/brain type alpha 1 subunit, Calcium channel voltage dependent L type alpha 1, Calcium channel voltage dependent L type alpha 1C subunit, Calcium channel voltage dependent L type alpha 1D subunit, Calcium channel, L type, alpha 1 polypeptide, isoform 3, skeletal, Calcium channel, L type, alpha 1 polypeptide, isoform 3, skeletal muscle, Calcium channel, L type, alpha 1 polypeptide, isoform 3, skeletal muscle, hypokalemic periodic paralysis, Calcium channel, skeletal muscle dihydropyridine sensitive , alpha 1 subunit, Calcium channel, voltage dependent, L type, alpha 1S subunit, Calcium channel, voltage-dependent, L type, alpha 1S subunit, b, Cav1.1, Cav1.3, Cholinergic receptor muscarinic 1, Cholinergic receptor muscarinic 4, Cholinergic receptor muscarinic 5, Chrm 4, Chrm 5, Colchicin sensitivity, Cytochrome P450 2J2, Cytochrome P450 family 2 subfamily J polypeptide 2, Cytochrome P450 subfamily IIJ (arachidonic acid epoxygenase) polypeptide 2, Cytochrome P450 subfamily IIJ polypeptide 2, D(2) dopamine receptor, D(3) dopamine receptor, D2 dopamine receptor, D2DR, D2R, DA transporter, DAT, DAT 1, DHPR alpha 1, DHPR alpha 1 subunit, DNA binding protein, DRD2_HUMAN, DRD3_HUMAN, Dihydropyridine receptor, Dihydropyridine sensitive L type calcium channel alpha 1 subunit, Dopamine D2 receptor, Dopamine D3 receptor, Dopamine receptor D2, Dopamine receptor D3, Dopamine transporter, Dopamine transporter 1, Doxorubicin resistance, EGBRS, ETM1, Eag-related protein 1, Ether a go go related potassium channel protein, Ether-a-go-go-related gene potassium channel 1, Ether-a-go-go-related protein 1, FET1, G-21, GBD1, GCPS, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI family zinc finger 3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3FL, GLI3_HUMAN, GP170, Gastric receptor 1, Gastric receptor I, Glioma associated oncogene family zinc finger 3, H-ERG, H1 R, HGNC:5183, HH1R, HH2R, HM 3, HM 4, HM 5, HM1, HOKPP, HRH1_HUMAN, HRH2_HUMAN, HTR 2, HTR 2A, HTR 6, HTR1D2, HTR1DB, HTR2, formerly, HTR2C, HisH1, Histamine H(1) receptor, Histamine H1 receptor, Histamine H2 receptor, Histamine receptor H1, Histamine receptor H2, Histamine receptor subclass H1, Htr 2b, Htr1b, Htr1c, HypoPP, ICP3, KCNH2_HUMAN, Kv11.1, L type, LMOR, LQT 2, LQT8, M-OR-1, M3 muscarinic receptor, M4, M5R, MAC30, MDR1_HUMAN, MDR2, MDR2/3, MDR3 P glycoprotein, MDR3 P gp, MDR3_HUMAN, MGC41838, MHS5, MOR, Malignant hyperthermia susceptibility 5, Microsomal monooxygenase, Mu opiate receptor, Mu opioid receptor, Mu-type opioid receptor, Multidrug resistance 1, Multidrug resistance protein 1, Multidrug resistance protein 3, Multiple drug resistance 3, Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M4, Muscarinic acetylcholine receptor M5, NK-2 receptor, NK2R_HUMAN, NKNAR, NP75 protein, NR1B1, Na+/Cl- dependent serotonin transporter, Neurokinin 2 receptor, Neurokinin A receptor, Neurotransmitter transporter, Norepinephrine transporter, Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein, Nuclear receptor subfamily 1 group B member 1, Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form, OCD1, OPRM1, OPRM_HUMAN, OTTHUMP00000010550, OTTHUMP00000058849, OTTHUMP00000161242, OTTHUMP00000161243, Oncogene GLI3, Opioid receptor mu 1, P-glycoprotein 1, P-glycoprotein 3, PAP A, PAPB, PASNA, PFIC 3, PGY 3, PGY1, PKDYS, PPD IV, Potassium channel HERG, Potassium voltage gated channel subfamily H (eag related) member 2, Potassium voltage-gated channel subfamily H member 2, Protein MAC30, RAR, RAR-alpha, RARA_HUMAN, RARalpha1, ROB1, RP23 167I12.6, Retinoic acid nuclear receptor alpha variant 1, Retinoic acid nuclear receptor alpha variant 2, Retinoic acid receptor alpha, Retinoic acid receptor alpha polypeptide, SANDD, SC6A2_HUMAN, SC6A3_HUMAN, SC6A4_HUMAN, SEROTONIN 5HT2B RECEPTOR, SERT, SERT1, SGMR1_HUMAN, SIG-1R, SKR, SLC6A3, SLC6A5, SQT1, SR-BP, SR31747-binding protein, Serotonin 1D beta receptor, Serotonin 5-HT-2C receptor, Serotonin receptor 1A, Serotonin receptor 1B, Serotonin receptor 2A, Serotonin receptor 2B, Serotonin receptor 2C, Serotonin receptor 6, Serotonin transporter 1, Seven transmembrane helix receptor, Sigma 1-type opioid receptor, Sigma non-opioid intracellular receptor 1, Sigma1-receptor, Sigma1R, Sigmar1, Slc6a2, Slc6a4, Sodium-dependent dopamine transporter, Sodium-dependent noradrenaline transporter, Sodium-dependent serotonin transporter, Solute carrier family 6 (neurotransmitter transporter dopamine), member 3, Solute carrier family 6 (neurotransmitter transporter norepinephrine) member 5, Solute carrier family 6 (neurotransmitter transporter) member 4, Solute carrier family 6 (neurotransmitter transporter), member 3, Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2, Solute carrier family 6 member 2, Solute carrier family 6 member 3, Solute carrier family 6 member 4, Solute carrier family 6 member 5, Stomach fundus serotonin receptor, Substance-K receptor, Subtype alpha2 C4, TAC 2R, TAC R2, TACR 2, TACR2, TMM97_HUMAN, TS, TTPP1, Tachykinin receptor 2, Tachykinin receptor 2 (substance K receptor; neurokinin 2 receptor), Transcriptional activator GLI3, Transcriptional repressor GLI3R, Transmembrane protein 97, Variable number tandem repeat (VNTR), Voltage dependent L type calcium channel alpha 1C subunit, Voltage gated L type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*, Voltage gated calcium channel alpha 1 subunit, Voltage gated calcium channel alpha subunit Cav1.2, Voltage gated calcium channel alpha subunit Cav1.3, Voltage gated potassium channel, subfamily H, member 2, Voltage-dependent L-type calcium channel subunit alpha-1C, Voltage-dependent L-type calcium channel subunit alpha-1D, Voltage-dependent L-type calcium channel subunit alpha-1S, Voltage-gated calcium channel subunit alpha Cav1.1, Voltage-gated calcium channel subunit alpha Cav1.2, Voltage-gated calcium channel subunit alpha Cav1.3, Voltage-gated potassium channel subunit Kv11.1, Zinc finger protein GLI 3, alpha 2BAR, alpha-1 polypeptide, alpha-2-adrenergic receptor, platelet type, alpha2 AR C4, alpha2 C4, alpha2C, alpha2cii-adrenergic receptor, cardiac muscle, cholinergic receptor muscarinic 3, eag homolog, flavoprotein-linked monooxygenase, fmd, hERG-1, hMOP, hSERT, hSigmaR1, isoform 1, isoform 2, isoform 3, m3 muscarinic acetylcholine receptor, m5, mSigmaR1, muscarinic 3, muscarinic cholinergic m3 receptor, muscarinic m3 receptor, opioid receptor, sigma 1, opioid receptor, sigma 1 isoform 1, serotonin 1c receptor, serotonin 2c receptor, serotonin 5-HT-2 receptor, formerly, serotonin 5-HT-2A receptor, sj, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
68844-77-9
> 99%
Solid
458.6 Da
C28H31FN4O
2247
Synthetic
MW 458.6 Da, Purity >99%. Potent, selective histamine H1 receptor antagonist (IC50 = 4 nM) and potent hERG K+ channel blocker (IC50 =0.9 nM). Orally active. Antiallergic agent. Active *in vivo* and *in vitro*.
Alternative names=3dopamine receptor, 5 HT 2B receptor, 5 HT(2B), 5 HT1DB, 5 HT2 receptor, 5 HTT, 5 HTTLPR, 5 Hydroxytryptamine 2C receptor, 5 hydroxytryptamine (serotonin) receptor 2B, 5 hydroxytryptamine (serotonin) receptor 2B G protein coupled, 5 hydroxytryptamine (serotonin) receptor 6 G protein coupled, 5 hydroxytryptamine (serotonin) transporter, 5 hydroxytryptamine 1A receptor, 5 hydroxytryptamine 2B receptor, 5 hydroxytryptamine 6 receptor, 5 hydroxytryptamine transporter, 5-HT-1C, 5-HT-1D-beta, 5-HT-2, 5-HT-6, 5-HTR2C, 5-ht-1c receptor, 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled, 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled, 5-hydroxytryptamine 2A receptor, 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine receptor 1C, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 6, 5HT transporter, 5HT1B_HUMAN, 5HT2A_HUMAN, 5HT2B_HUMAN, 5HT2C_HUMAN, 5HT2F, 5HT6R_HUMAN, ABC 21, ABC20, ABCB1, ABCB4 protein, ACLS, ACM3_HUMAN, ACM4_HUMAN, ACM5_HUMAN, AChR, AChR M5, ADA1D_HUMAN, ADA2A_HUMAN, ADA2C_HUMAN, ADRA1A, ADRA1L1, ADRA2, ADRA2A, ADRA2L2, ADRA2R, ADRA2RL1, ADRA2RL2, ADRAR, ADRARL1, ADRARL2, ADRB2RL1, ADRBRL1, AL024364, ATP binding cassette sub family B MDR/TAP member 4, ATP binding cassette, sub family B (MDR/TAP), member 1, ATP-binding cassette sub-family B member 1, ATP-binding cassette sub-family B member 4, Acetylcholine receptor muscarinic 5, Adra 2c, Adra1d, Adrenergic alpha 1A receptor, Adrenergic alpha 1B receptor, Adrenergic alpha 1C receptor, Adrenergic alpha 1D receptor, Adrenergic alpha 2A receptor, Adrenergic alpha 2C receptor, Adrenoceptor alpha 2C, Aging-associated gene 8 protein, Alpha 2 adrenergic receptor subtype C2, Alpha 2AAR subtype C10, Alpha 2B adrenoceptor, Alpha 2B adrenoreceptor, Alpha 2C adrenergic receptor subtype C4, Alpha adrenergic receptor 1b, Alpha adrenergic receptor 1d, Alpha-1A adrenergic receptor, Alpha-1A adrenoreceptor, Alpha-1C adrenergic receptor, Alpha-1D adrenergic receptor, Alpha-1D adrenoceptor, Alpha-1D adrenoreceptor, Alpha-2 adrenergic receptor subtype C10, Alpha-2 adrenergic receptor subtype C4, Alpha-2-adrenergic receptor, renal type, Alpha-2A adrenergic receptor, Alpha-2A adrenoceptor, Alpha-2A adrenoreceptor, Alpha-2AAR, Alpha-2C adrenergic receptor, Alpha-2C adrenoceptor, Alpha-2C adrenoreceptor, Alpha-2CAR, Alpha-adrenergic receptor 1a, Alpha-adrenergic receptor 1c, Arachidonic acid epoxygenase, BPHS, mouse, homolog of, CAC1C_HUMAN, CAC1D_HUMAN, CAC1S_HUMAN, CACH 2, CACH1, CACH3, CACN 2, CACN1, CACN4, CACNA 1D, CACNL1A1, CACNL1A2, CACNL1A3, CCHL1A1, CCHL1A2, CCHL1A3, CD243, CHKM5MR, CHRM 3, CHRM1, CLCS, CP2J2_HUMAN, CPJ2, CYPIIJ2, CaV1.2, Cach1b, Calcium channel, Calcium channel L type alpha 1 polypeptide isoform 1 cardiac muscle, Calcium channel L type alpha 1 polypeptide isoform 2, Calcium channel cardic dihydropyridine sensitive alpha 1 subunit, Calcium channel neuroendocrine/brain type alpha 1 subunit, Calcium channel voltage dependent L type alpha 1, Calcium channel voltage dependent L type alpha 1C subunit, Calcium channel voltage dependent L type alpha 1D subunit, Calcium channel, L type, alpha 1 polypeptide, isoform 3, skeletal, Calcium channel, L type, alpha 1 polypeptide, isoform 3, skeletal muscle, Calcium channel, L type, alpha 1 polypeptide, isoform 3, skeletal muscle, hypokalemic periodic paralysis, Calcium channel, skeletal muscle dihydropyridine sensitive , alpha 1 subunit, Calcium channel, voltage dependent, L type, alpha 1S subunit, Calcium channel, voltage-dependent, L type, alpha 1S subunit, b, Cav1.1, Cav1.3, Cholinergic receptor muscarinic 1, Cholinergic receptor muscarinic 4, Cholinergic receptor muscarinic 5, Chrm 4, Chrm 5, Colchicin sensitivity, Cytochrome P450 2J2, Cytochrome P450 family 2 subfamily J polypeptide 2, Cytochrome P450 subfamily IIJ (arachidonic acid epoxygenase) polypeptide 2, Cytochrome P450 subfamily IIJ polypeptide 2, D(2) dopamine receptor, D(3) dopamine receptor, D2 dopamine receptor, D2DR, D2R, DA transporter, DAT, DAT 1, DHPR alpha 1, DHPR alpha 1 subunit, DNA binding protein, DRD2_HUMAN, DRD3_HUMAN, Dihydropyridine receptor, Dihydropyridine sensitive L type calcium channel alpha 1 subunit, Dopamine D2 receptor, Dopamine D3 receptor, Dopamine receptor D2, Dopamine receptor D3, Dopamine transporter, Dopamine transporter 1, Doxorubicin resistance, EGBRS, ETM1, Eag-related protein 1, Ether a go go related potassium channel protein, Ether-a-go-go-related gene potassium channel 1, Ether-a-go-go-related protein 1, FET1, G-21, GBD1, GCPS, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI family zinc finger 3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3FL, GLI3_HUMAN, GP170, Gastric receptor 1, Gastric receptor I, Glioma associated oncogene family zinc finger 3, H-ERG, H1 R, HGNC:5183, HH1R, HH2R, HM 3, HM 4, HM 5, HM1, HOKPP, HRH1_HUMAN, HRH2_HUMAN, HTR 2, HTR 2A, HTR 6, HTR1D2, HTR1DB, HTR2, formerly, HTR2C, HisH1, Histamine H(1) receptor, Histamine H1 receptor, Histamine H2 receptor, Histamine receptor H1, Histamine receptor H2, Histamine receptor subclass H1, Htr 2b, Htr1b, Htr1c, HypoPP, ICP3, KCNH2_HUMAN, Kv11.1, L type, LMOR, LQT 2, LQT8, M-OR-1, M3 muscarinic receptor, M4, M5R, MAC30, MDR1_HUMAN, MDR2, MDR2/3, MDR3 P glycoprotein, MDR3 P gp, MDR3_HUMAN, MGC41838, MHS5, MOR, Malignant hyperthermia susceptibility 5, Microsomal monooxygenase, Mu opiate receptor, Mu opioid receptor, Mu-type opioid receptor, Multidrug resistance 1, Multidrug resistance protein 1, Multidrug resistance protein 3, Multiple drug resistance 3, Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M4, Muscarinic acetylcholine receptor M5, NK-2 receptor, NK2R_HUMAN, NKNAR, NP75 protein, NR1B1, Na+/Cl- dependent serotonin transporter, Neurokinin 2 receptor, Neurokinin A receptor, Neurotransmitter transporter, Norepinephrine transporter, Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein, Nuclear receptor subfamily 1 group B member 1, Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form, OCD1, OPRM1, OPRM_HUMAN, OTTHUMP00000010550, OTTHUMP00000058849, OTTHUMP00000161242, OTTHUMP00000161243, Oncogene GLI3, Opioid receptor mu 1, P-glycoprotein 1, P-glycoprotein 3, PAP A, PAPB, PASNA, PFIC 3, PGY 3, PGY1, PKDYS, PPD IV, Potassium channel HERG, Potassium voltage gated channel subfamily H (eag related) member 2, Potassium voltage-gated channel subfamily H member 2, Protein MAC30, RAR, RAR-alpha, RARA_HUMAN, RARalpha1, ROB1, RP23 167I12.6, Retinoic acid nuclear receptor alpha variant 1, Retinoic acid nuclear receptor alpha variant 2, Retinoic acid receptor alpha, Retinoic acid receptor alpha polypeptide, SANDD, SC6A2_HUMAN, SC6A3_HUMAN, SC6A4_HUMAN, SEROTONIN 5HT2B RECEPTOR, SERT, SERT1, SGMR1_HUMAN, SIG-1R, SKR, SLC6A3, SLC6A5, SQT1, SR-BP, SR31747-binding protein, Serotonin 1D beta receptor, Serotonin 5-HT-2C receptor, Serotonin receptor 1A, Serotonin receptor 1B, Serotonin receptor 2A, Serotonin receptor 2B, Serotonin receptor 2C, Serotonin receptor 6, Serotonin transporter 1, Seven transmembrane helix receptor, Sigma 1-type opioid receptor, Sigma non-opioid intracellular receptor 1, Sigma1-receptor, Sigma1R, Sigmar1, Slc6a2, Slc6a4, Sodium-dependent dopamine transporter, Sodium-dependent noradrenaline transporter, Sodium-dependent serotonin transporter, Solute carrier family 6 (neurotransmitter transporter dopamine), member 3, Solute carrier family 6 (neurotransmitter transporter norepinephrine) member 5, Solute carrier family 6 (neurotransmitter transporter) member 4, Solute carrier family 6 (neurotransmitter transporter), member 3, Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2, Solute carrier family 6 member 2, Solute carrier family 6 member 3, Solute carrier family 6 member 4, Solute carrier family 6 member 5, Stomach fundus serotonin receptor, Substance-K receptor, Subtype alpha2 C4, TAC 2R, TAC R2, TACR 2, TACR2, TMM97_HUMAN, TS, TTPP1, Tachykinin receptor 2, Tachykinin receptor 2 (substance K receptor; neurokinin 2 receptor), Transcriptional activator GLI3, Transcriptional repressor GLI3R, Transmembrane protein 97, Variable number tandem repeat (VNTR), Voltage dependent L type calcium channel alpha 1C subunit, Voltage gated L type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*, Voltage gated calcium channel alpha 1 subunit, Voltage gated calcium channel alpha subunit Cav1.2, Voltage gated calcium channel alpha subunit Cav1.3, Voltage gated potassium channel, subfamily H, member 2, Voltage-dependent L-type calcium channel subunit alpha-1C, Voltage-dependent L-type calcium channel subunit alpha-1D, Voltage-dependent L-type calcium channel subunit alpha-1S, Voltage-gated calcium channel subunit alpha Cav1.1, Voltage-gated calcium channel subunit alpha Cav1.2, Voltage-gated calcium channel subunit alpha Cav1.3, Voltage-gated potassium channel subunit Kv11.1, Zinc finger protein GLI 3, alpha 2BAR, alpha-1 polypeptide, alpha-2-adrenergic receptor, platelet type, alpha2 AR C4, alpha2 C4, alpha2C, alpha2cii-adrenergic receptor, cardiac muscle, cholinergic receptor muscarinic 3, eag homolog, flavoprotein-linked monooxygenase, fmd, hERG-1, hMOP, hSERT, hSigmaR1, isoform 1, isoform 2, isoform 3, m3 muscarinic acetylcholine receptor, m5, mSigmaR1, muscarinic 3, muscarinic cholinergic m3 receptor, muscarinic m3 receptor, opioid receptor, sigma 1, opioid receptor, sigma 1 isoform 1, serotonin 1c receptor, serotonin 2c receptor, serotonin 5-HT-2 receptor, formerly, serotonin 5-HT-2A receptor, sj, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
68844-77-9
> 99%
Solid
458.6 Da
C28H31FN4O
2247
Synthetic
In water, 4.3X10-2 mg/L at 25 °C (est).
Astemizole
Potent, selective histamine H1 receptor antagonist (IC50 = 4 nM) and potent hERG K+ channel blocker (IC50 =0.9 nM). Orally active. Antiallergic agent. Active *in vivo* and *in vitro*.
COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F
InChI=1S/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-20H2,1H3,(H,30,31)
GXDALQBWZGODGZ-UHFFFAOYSA-N
1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl]benzimidazol-2-amine
Ambient - Can Ship with Ice
Ambient
The product can be stored for up to 12 months
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