Skip to main content

MW 458.6 Da, Purity >99%. Potent, selective histamine H1 receptor antagonist (IC50 = 4 nM) and potent hERG K+ channel blocker (IC50 =0.9 nM). Orally active. Antiallergic agent. Active *in vivo* and *in vitro*.

This product has no reviews yet! Submit a review

CAS number

68844-77-9

Purity

> 99%

Form

Solid

Molecular weight

458.6 Da

Molecular formula

C28H31FN4O

PubChem identifier

2247

Nature

Synthetic

Loading...
Loading...
Loading...
Loading...
Loading...
Loading...
Loading...
Shipping To:
United States

Images

Target data

Recommended products

  1. Loading...
  2. Loading...
  3. Loading...
  4. Loading...

MW 458.6 Da, Purity >99%. Potent, selective histamine H1 receptor antagonist (IC50 = 4 nM) and potent hERG K+ channel blocker (IC50 =0.9 nM). Orally active. Antiallergic agent. Active *in vivo* and *in vitro*.

Key facts

Purity

> 99%

PubChem identifier

2247

Solubility

In water, 4.3X10-2 mg/L at 25 °C (est).

Biochemical name

Astemizole

Biological description

Potent, selective histamine H1 receptor antagonist (IC50 = 4 nM) and potent hERG K+ channel blocker (IC50 =0.9 nM). Orally active. Antiallergic agent. Active *in vivo* and *in vitro*.

Canonical SMILES

COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F

InChI

InChI=1S/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-20H2,1H3,(H,30,31)

InChIKey

GXDALQBWZGODGZ-UHFFFAOYSA-N

IUPAC name

1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl]benzimidazol-2-amine

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate long-term storage conditions

Ambient

Storage information

The product can be stored for up to 12 months

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

There was a problem

We can’t download that datasheet. Please try again. If you need help, contact our Customer Services team at technical@abcam.com