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MW 1155.3 Da, Purity >99%. Potent HMG-CoA reductase inhibitor (IC50 = 8 nM). Metabolised by CYP3A4. Able to reduce circulating LDL-C through inhibition of cholesterol biosynthesis and inducing expression of LDL receptors.

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Images

Chemical Structure - Atorvastatin hemicalcium salt, HMG-CoA reductase inhibitor (AB141083), expandable thumbnail
  • Immunocytochemistry/ Immunofluorescence - Atorvastatin hemicalcium salt, HMG-CoA reductase inhibitor (AB141083), expandable thumbnail

Publications

Key facts

CAS number

134523-03-8

Purity

> 99%

Form

Solid

Molecular weight

1155.3 Da

Molecular formula

C66H68CaF2N4O10

PubChem identifier

60822

Nature

Synthetic

Alternative names

Recommended products

MW 1155.3 Da, Purity >99%. Potent HMG-CoA reductase inhibitor (IC50 = 8 nM). Metabolised by CYP3A4. Able to reduce circulating LDL-C through inhibition of cholesterol biosynthesis and inducing expression of LDL receptors.

Key facts

Purity

> 99%

PubChem identifier

60822

Solubility

Soluble in DMSO to 100 mM.

Biochemical name

Atorvastatin calcium

Biological description

Potent HMG-CoA reductase inhibitor (IC50 = 8 nM). Metabolised by CYP3A4. Able to reduce circulating LDL-C through inhibition of cholesterol biosynthesis and inducing expression of LDL receptors.

Canonical SMILES

CC(C)C1=C(C(=C(N1CCC(CC(CC(=O)[O-])O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4.CC(C)C1=C(C(=C(N1CCC(CC(CC(=O)[O-])O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4.[Ca+2]

Isomeric SMILES

CC(C)C1=C(C(=C(N1CC[C@H](C[C@H](CC(=O)[O-])O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4.CC(C)C1=C(C(=C(N1CC[C@H](C[C@H](CC(=O)[O-])O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4.[Ca+2]

InChI

InChI=1S/2C33H35FN2O5.Ca/c2*1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40;/h2*3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40);/q;;+2/p-2/t2*26-,27-;/m11./s1

InChIKey

FQCKMBLVYCEXJB-MNSAWQCASA-L

IUPAC name

calcium;(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Storage information

It is important to note that this product is reported to be light sensitive, Store in the dark, Store under desiccating conditions

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2 product images

  • Chemical Structure - Atorvastatin hemicalcium salt, HMG-CoA reductase inhibitor (ab141083), expandable thumbnail

    Chemical Structure - Atorvastatin hemicalcium salt, HMG-CoA reductase inhibitor (ab141083)

    2D chemical structure image of ab141083, Atorvastatin hemicalcium salt, HMG-CoA reductase inhibitor

  • Immunocytochemistry/ Immunofluorescence - Atorvastatin hemicalcium salt, HMG-CoA reductase inhibitor (ab141083), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - Atorvastatin hemicalcium salt, HMG-CoA reductase inhibitor (ab141083)

    Anti-Cytochrome C antibody ab90529 staining cytochrome C in HepG2 cells treated with atorvastatin hemicalcium salt (ab141083), by ICC/IF. Increase of cytochrome C expression correlates with increased concentration of atorvastatin hemicalcium salt, as described in literature.
    The cells were incubated at 37°C for 4 hours in media containing different concentrations of ab141083 (atorvastatin hemicalcium salt) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with Anti-Cytochrome C antibody ab90529 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

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