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MW 547.1 Da, Purity >80%. Substrate and inhibitor of ATP-dependent enzyme systems. Hydrolyzed very slowly by phosphatases and most ATPases. Once thiophosphorylated, proteins are resistant to protein phosphatases. P2 purinergic receptor agonist.
Alternative names=ATP g S, Adenosine 5' (3 thiotriphosphate)tetralithium salt, Ado 5' PPP[S]
- CAS number
93839-89-5
- Purity
> 80%
- Form
Solid
- Molecular weight
547.1 Da
- Molecular formula
C10H12Li4N5O12P3S
- PubChem identifier
5311341
- Nature
Synthetic
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MW 547.1 Da, Purity >80%. Substrate and inhibitor of ATP-dependent enzyme systems. Hydrolyzed very slowly by phosphatases and most ATPases. Once thiophosphorylated, proteins are resistant to protein phosphatases. P2 purinergic receptor agonist.
Alternative names=ATP g S, Adenosine 5' (3 thiotriphosphate)tetralithium salt, Ado 5' PPP[S]
Key facts
- CAS number
93839-89-5
- Purity
> 80%
- Form
Solid
- Molecular weight
547.1 Da
- Molecular formula
C10H12Li4N5O12P3S
- PubChem identifier
5311341
- Nature
Synthetic
- Biochemical name
Adenosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid, tetralithium salt
- Biological description
Substrate and inhibitor of ATP-dependent enzyme systems. Hydrolyzed very slowly by phosphatases and most ATPases. Once thiophosphorylated, proteins are resistant to protein phosphatases. P2 purinergic receptor agonist.
- Canonical SMILES
[Li+].[Li+].[Li+].[Li+].C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)([O-])OP(=O)([O-])OP(=S)([O-])[O-])O)O)N
- Isomeric SMILES
[Li+].[Li+].[Li+].[Li+].C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)([O-])OP(=O)([O-])OP(=S)([O-])[O-])O)O)N
- InChI
InChI=1S/C10H16N5O12P3S.4Li/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-28(18,19)26-29(20,21)27-30(22,23)31;;;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H,20,21)(H2,11,12,13)(H2,22,23,31);;;;/q;4*+1/p-4/t4-,6-,7-,10-;;;;/m1..../s1
- InChIKey
DWQFDOIBOYDYKH-KWIZKVQNSA-J
- IUPAC name
tetralithium;[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] dioxidophosphinothioyl phosphate
Storage
- Shipped at conditions
Blue Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
Notes
Kinase reaction reagent to be used with ab92570 rabbit monoclonal to thiophosphate ester for the identification of direct kinase substrates as mentioned in Allen JJ et al. Nat Methods 4:511-6 (2007).
After the kinase of interest has accepted ATP-γ-S, p-Nitrobenzyl mesylate (ab138910) can be used to alkylate the thiophospholyation site on the substrates. A thiophosphate ester rabbit monoclonal antibody (ab92570) is introduced to identify the tagged substrates.
For western blot analysis, we used ATPγS or A*TPγS analogs at a concentration of 1 mM. For kinetic measurements, ATPγS or A*TPγS analog concentration varied from 0.1 μM to 250 μM. See Allen JJ et al. Nat Methods 4:511-6 (2007); Supp. Material.
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