Auranofin, inhibits both leukocyte activation pathways

Key facts

CAS number

34031-32-8

Purity

>98%

Form

Solid

form

Molecular weight

678.5 Da

Molecular formula

C₂₀H₃₄AuO₉PS

PubChem

24199313

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

Biochemical name

(1-Thio-beta-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetate

Biological description

Organic gold compound. Anti-inflammatory and antiproliferative agent. Glutathione S-transferase P1-1 inhibitor (IC50 = 33 μM). Shows antiproliferative effects through STAT3 inhibition. Shows anti-inflammatory effects *in vivo*. Orally active.

Canonical smiles

CCP(CC)CC.CC(=O)OCC1C(C(C(C(O1)[S-])OC(=O)C)OC(=O)C)OC(=O)C.[Au+]

InChi

InChI=1S/C14H20O9S.C6H15P.Au/c1-6(15)19-5-10-11(20-7(2)16)12(21-8(3)17)13(14(24)23-10)22-9(4)18;1-4-7(5-2)6-3;/h10-14,24H,5H2,1-4H3;4-6H2,1-3H3;/q;;+1/p-1

InChiKey

AUJRCFUBUPVWSZ-UHFFFAOYSA-M

IUPAC Name

gold(1+);3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphane