MW 678.5 Da, Purity >98%. Organic gold compound. Anti-inflammatory and antiproliferative agent. Glutathione S-transferase P1-1 inhibitor (IC50 = 33 μM). Shows antiproliferative effects through STAT3 inhibition. Shows anti-inflammatory effects *in vivo*. Orally active.
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Publications
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- PloS one 11:e01663862016Auranofin Inhibits Retinal Pigment Epithelium Cell Survival through Reactive Oxygen Species-Dependent Epidermal Growth Factor Receptor/ Mitogen-Activated Protein Kinase Signaling Pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaodong Chen et. al.PubMed 27846303
- The Journal of biological chemistry 291:21496-215092016Therapeutic Strategy for Targeting Aggressive Malignant Gliomas by Disrupting Their Energy Balance.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAhmed M Hegazy et. al.PubMed 27519418
Key facts
- CAS number
- 34031-32-8
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 678.5 Da
- Molecular formula
- C20H34AuO9PS
- PubChem identifier
- 24199313
- Nature
- Synthetic
Target data
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MW 678.5 Da, Purity >98%. Organic gold compound. Anti-inflammatory and antiproliferative agent. Glutathione S-transferase P1-1 inhibitor (IC50 = 33 μM). Shows antiproliferative effects through STAT3 inhibition. Shows anti-inflammatory effects *in vivo*. Orally active.
Key facts
- CAS number
- 34031-32-8
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 678.5 Da
- Molecular formula
- C20H34AuO9PS
- PubChem identifier
- 24199313
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
Soluble in ethanol to 100 mM.
- Biochemical name
- (1-Thio-beta-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetate
- Biological description
Organic gold compound. Anti-inflammatory and antiproliferative agent. Glutathione S-transferase P1-1 inhibitor (IC50 = 33 μM). Shows antiproliferative effects through STAT3 inhibition. Shows anti-inflammatory effects *in vivo*. Orally active.
- Canonical SMILES
- CCP(CC)CC.CC(=O)OCC1C(C(C(C(O1)[S-])OC(=O)C)OC(=O)C)OC(=O)C.[Au+]
- InChI
- InChI=1S/C14H20O9S.C6H15P.Au/c1-6(15)19-5-10-11(20-7(2)16)12(21-8(3)17)13(14(24)23-10)22-9(4)18;1-4-7(5-2)6-3;/h10-14,24H,5H2,1-4H3;4-6H2,1-3H3;/q;;+1/p-1
- InChIKey
- AUJRCFUBUPVWSZ-UHFFFAOYSA-M
- IUPAC name
- gold(1+);3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphane
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- It is important to note that this product is reported to be light sensitive, Store in the dark
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1 product image
Chemical Structure - Auranofin, inhibits both leukocyte activation pathways (ab141509)
2D chemical structure image of ab141509, Auranofin, inhibits both leukocyte activation pathways
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