Aurintricarboxylic acid (ATA), Apoptosis inhibitor

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MPG/AAG refers to the N-methylpurine DNA glycosylase enzyme also known as AAG. It is involved in the DNA repair process by excising damaged purines from DNA contributing to base excision repair. DNA Polymerase beta with a mass of about 39 kDa is mainly expressed in the nucleus and plays a role in DNA repair as well. Blooms Syndrome Protein Blm is a helicase implicated in maintaining genome stability. Other targets include cytochrome P450 2C19 part of a superfamily involved in drug metabolism and FEN1 with roles in DNA replication and repair. Many of these proteins share structural roles or associate with DNA and chromatin.

Biological function summary

The proteins within this list function to maintain DNA integrity and cellular homeostasis. DNA Polymerase iota and Polymerase eta help to bypass DNA lesions to continue replication mitigating damage-induced stalls. Apoptosis inhibitors work to control programmed cell death with proteins like CBX1/HP1 beta playing roles in chromatin organization and gene expression. USP2 acts as a deubiquitinase reversing protein ubiquitination and stabilizing proteins within cellular pathways. These proteins often assemble into complexes like the RUNX1/AML1 and CBFb forming transcription factor complexes important in gene regulation.

Pathways

These targets integrate into DNA repair and apoptosis regulation pathways. DNA Polymerase Kappa/POLK participates in the translesion synthesis pathway to cope with DNA damage by using polymerases like DNA Polymerase eta and Blm-related helicase activities. FEN1 and APE1 hold significant roles in the base excision repair pathway working closely with other repair enzymes to preserve genomic stability. Apoptosis inhibitor pathways involve regulatory proteins like Pin1 and RUNX1 which modulate cell survival signals.

These proteins relate to cancer and Bloom's syndrome. For instance mutations in Bloom's Syndrome Protein Blm increase cancer risk due to chromosomal instability while alterations in the transcription factor RUNX1/AML1 often occur in leukemia. Cytochrome P450 2C19 has pharmacogenetic implications for drug metabolism in liver diseases. Dysfunction of DNA Polymerase beta or iota links to repair deficiencies seen in tumorigenesis. These proteins through their interactions and dysfunctions highlight their significance in understanding and addressing these conditions.