MW 422.3 Da. Inhibits endonucleases and downstream apoptosis. Displays a multitude of biological activities including inhibition of protein-nucleic acid interactions and topisomerase II. Inhibits protein synthesis.
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Key facts
- CAS number
- 4431-00-9
- Form
- Solid
- Molecular weight
- 422.3 Da
- Molecular formula
- C22H14O9
- PubChem identifier
- 2259
- Nature
- Synthetic
Alternative names
(R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, 1110051E14Rik, 15 LIPOXYGENASE RETICULOCYTE ARACHIDONATE, 15 LOX 1, 15 lipoxygenase 1, 15-LOX, 3-alkyladenine DNA glycosylase, 3-methyladenine DNA glycosidase, 3MG_HUMAN, 41 kDa ubiquitin-specific protease, AAG, ADPG, ALOX15, AML 1, AML1 EVI 1, AML1 EVI 1 fusion protein, AMLCR 1, AP endonuclease 1, AP endonuclease class I, AP lyase, APE, APEN, APEX, APEX nuclease, APEX nuclease (multifunctional DNA repair enzyme) 1, APEX1_HUMAN, APG4 autophagy 4 homolog B, APG4B, APNG, APX, ARMD15, ATG4 autophagy related 4 homolog B (S. cerevisiae), ATG4B_HUMAN, AUT-like 1 cysteine endopeptidase, AUTL1, AW212720, Acute myeloid leukemia 1, Acute myeloid leukemia 1 protein, Alkyladenine DNA glycosylase, Aml1 oncogene, Apex nuclease 1, Apurinic endonuclease, Apurinic-apyrimidinic endonuclease 1, Apurinic/apyrimidinic (abasic) endonuclease, Apurinic/apyrimidinic endonuclease 1, Apurinic/apyrimidinic exonuclease, Arachidonate 15-lipoxygenase, Arachidonate omega-6 lipoxygenase, Autophagin-1, Autophagy related 4B cysteine peptidase, Autophagy-related cysteine endopeptidase 1, Autophagy-related protein 4 homolog B, BAZ2B_HUMAN, BLM_HUMAN, BS, Bloom syndrome, Bloom syndrome RecQ helicase like, Bloom syndrome protein, Bromodomain adjacent to zinc finger domain 2B, Bromodomain adjacent to zinc finger domain protein 2B, C9, C9 deficiency, C9 deficiency with dermatomyositis, C9D, CBF b, CBF-alpha-2, CBF-beta, CBFA 2, CBX, CBX1_HUMAN, CO9_HUMAN, CP2C9_HUMAN, CP2CJ_HUMAN, CPC9, CPCJ, CRA36.1, CYP2C, CYP2C10, CYP2C19, CYPIIC17, CYPIIC19, CYPIIC9, Chromobox 1, Chromobox homolog 1 (HP1 beta homolog Drosophila ), Chromobox protein homolog 1, Complement component 9, Complement component 9 deficiency, Complement component C9, Complement component C9b, Core binding factor alpha 2 subunit, Core binding factor beta subunit, Core binding factor runt domain alpha subunit 2, Core-binding factor subunit alpha-2, Core-binding factor subunit beta, Core-binding factor, beta subunit (CBFB), transcript variant 2, Cysteine protease ATG4B, Cytochrome P-450 II C, Cytochrome P-450MP, Cytochrome P450 2C19, Cytochrome P450 2C9, Cytochrome P450 MP-4, Cytochrome P450 MP-8, Cytochrome P450 PB-1, Cytochrome P450, family 2, subfamily C, polypeptide 9, Cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19, Cytochrome P450-11A, Cytochrome P450-254C, DINB protein, DINB1, DINP, DKFZp434H071, DKFZp762I0516, DNA damage inducible protein b, DNA directed DNA polymerase beta, DNA helicase, DNA helicase RecQ like type 2, DNA pol beta, DNA polymerase beta, DNA polymerase beta subunit, DNA polymerase eta, DNA polymerase iota, DNA polymerase kappa, DNA-(apurinic or apyrimidinic site) lyase, DNA-(apurinic or apyrimidinic site) lyase, mitochondrial, DNA-3-methyladenine glycosylase, DNase IV, DOD, DODO, Drosophila, homolog of, DPOLB_HUMAN, Deoxyribonuclease (apurinic or apyrimidinic), Deubiquitinating enzyme 2, DinB homolog 1 (E. coli), Drosophila HP1 beta, EC 2.3.1.48, EC 4.2.99.18, Eta 2, FEN1_HUMAN, FLJ16395, FLJ21978, FLJ40239, FLJ45644, FLJ77628, Flap endonuclease 1, Flap structure-specific endonuclease 1, GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2, GCN5 general control of amino-acid synthesis 5-like 2 (yeast), GCN5L2, General control of amino acid synthesis protein 5-like 2, General control of amino acid synthesis, yeast, homolog-like 2, HGCN5, HGNC, HP1 beta, HP1 beta homolog, HP1 beta homolog Drosophila, HP1, Drosophila. homolog of, beta, HP1Hs beta, HSMPP8, Heterochromatin protein 1 beta, Heterochromatin protein 1 homolog beta, Heterochromatin protein p25, Histone acetyltransferase GCN5, Histone acetyltransferase KAT2A, Human Apurinic endonuclease 1, Human heterochromatin protein p25 mRNA complete cds, K(lysine) acetyltransferase 2A, KAT2A_HUMAN, LOG15, LOX15_HUMAN, Lysine acetyltransferase 2A, M-phase phosphoprotein 8, M-phase phosphoprotein, mpp, M-phase phosphoprotein, mpp8, M31, MF1, MGC102791, MGC10717, MGC125976, MGC126616, MGC131618, MGC131620, MGC1353, MGC139790, MGC149605, MGC88320, MOD 1, MPHOSPH8, MPP8_HUMAN, Maturation factor 1, Mephenytoin 4-hydroxylase, Microsomal monooxygenase, Modifier 1 protein, Mpg, Multifunctional DNA repair enzyme, N methylpurine DNA glycosirase, N-methylpurine-DNA glycosylase, NIMA interacting 1, OTTHUMP00000020135, OTTHUMP00000108696, OTTHUMP00000108697, OTTHUMP00000108699, OTTHUMP00000108700, OTTHUMP00000108702, OTTHUMP00000162897, OTTHUMP00000162898, Oncogene AML-1, P450 MP, P450 PB 1, P450-11A, P450C2C, P450IIC9, PCAF-b, PEA 2, PEA2-alpha B, PEA2-beta, PEBB_HUMAN, PEBP 2B, PEBP2-alpha B, PEBP2-beta, PEBP2A2, PEBP2aB, PIG11, PIG16, PIN1_HUMAN, POLH_HUMAN, POLI_HUMAN, POLK_HUMAN, POLQ, PPIase Pin1, Peptidyl prolyl cis/trans isomerase NIMA interacting, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Peptidyl-prolyl cis-trans isomerase pin1, Peptidylprolyl cis/trans isomerase NIMA interacting 1, Pol B, Pol beta, Polymerase (DNA directed) beta, Polymerase (DNA directed) iota, Polymerase (DNA directed) kappa, Polyomavirus enhancer-binding protein 2 alpha B subunit, Polyomavirus enhancer-binding protein 2 beta subunit, Proliferation inducing protein 11, Proliferation inducing protein 16, Prolyl isomerase, Protein (peptidylprolyl cis/trans isomerase) NIMA interacting 1, Protein NIMA interacting 1, RAD 30B, RAD30, RAD30 homolog A, RAD30 homolog B, RAD30, S. cerevisiae, homolog of, RAD30A, RAD3OB, RECQ 2, RECQ like, RECQL 2, RECQL 3, REF 1 protein, REF-1, RP11-523H24.1, RUNX1_HUMAN, Rad2, RecQ protein-like 3, RecQ-like type 2, Redox factor-1, Rotamase Pin1, Run1, Runt-related transcription factor 1, S-mephenytoin 4-hydroxylase, SL3 3 enhancer factor 1 beta subunit, SL3-3 enhancer factor 1 alpha B subunit, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor alpha B subunit, SL3/AKV core-binding factor beta subunit, STAF97, Twa3, Two hybrid-associated protein 3 with RanBPM, UBP-t, UBP2_HUMAN, UBP41, USP9, Ubiquitin carboxyl-terminal hydrolase 2, Ubiquitin specific protease 12, Ubiquitin specific protease, 41kD, Ubiquitin thioesterase 2, Ubiquitin thiolesterase 2, Ubiquitin-specific protease 9, Ubiquitin-specific-processing protease 2, Ubiquitin-specific-processing protease testis, WALp4, XP V, Xenobiotic monooxygenase, Xeroderma pigmentosum variant type protein, alpha subunit core binding factor, anpg, chromobox homolog 1, cytochrome P-450 S-mephenytoin 4-hydroxylase, flavoprotein-linked monooxygenase, general control of amino acid synthesis 5-like 2, hAPG4B, hFEN-1, hWALp4, heterochromatin protein p25 beta, hsGCN5, p25beta, polymerase DNA directed eta, polymerase, DNA, kappa, type 2, ubiquitin specific peptidase 2
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MW 422.3 Da. Inhibits endonucleases and downstream apoptosis. Displays a multitude of biological activities including inhibition of protein-nucleic acid interactions and topisomerase II. Inhibits protein synthesis.
Key facts
- CAS number
- 4431-00-9
- Form
- Solid
- Molecular weight
- 422.3 Da
- Molecular formula
- C22H14O9
- PubChem identifier
- 2259
- Nature
- Synthetic
- Solubility
Soluble in ethanol to 100 mM.
Soluble in DMSO to 100 mM.
- Biochemical name
- Aurintricarboxylic acid
- Biological description
Inhibits endonucleases and downstream apoptosis. Displays a multitude of biological activities including inhibition of protein-nucleic acid interactions and topisomerase II. Inhibits protein synthesis.
- Canonical SMILES
- C1=CC(=C(C=C1C(=C2C=CC(=O)C(=C2)C(=O)O)C3=CC(=C(C=C3)O)C(=O)O)C(=O)O)O
- InChI
- InChI=1S/C22H14O9/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31)
- InChIKey
- GIXWDMTZECRIJT-UHFFFAOYSA-N
- IUPAC name
- 5-[(3-carboxy-4-hydroxyphenyl)-(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-2-hydroxybenzoic acid
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
MPG/AAG refers to the N-methylpurine DNA glycosylase enzyme also known as AAG. It is involved in the DNA repair process by excising damaged purines from DNA contributing to base excision repair. DNA Polymerase beta with a mass of about 39 kDa is mainly expressed in the nucleus and plays a role in DNA repair as well. Blooms Syndrome Protein Blm is a helicase implicated in maintaining genome stability. Other targets include cytochrome P450 2C19 part of a superfamily involved in drug metabolism and FEN1 with roles in DNA replication and repair. Many of these proteins share structural roles or associate with DNA and chromatin.
- Biological function summary
The proteins within this list function to maintain DNA integrity and cellular homeostasis. DNA Polymerase iota and Polymerase eta help to bypass DNA lesions to continue replication mitigating damage-induced stalls. Apoptosis inhibitors work to control programmed cell death with proteins like CBX1/HP1 beta playing roles in chromatin organization and gene expression. USP2 acts as a deubiquitinase reversing protein ubiquitination and stabilizing proteins within cellular pathways. These proteins often assemble into complexes like the RUNX1/AML1 and CBFb forming transcription factor complexes important in gene regulation.
- Pathways
These targets integrate into DNA repair and apoptosis regulation pathways. DNA Polymerase Kappa/POLK participates in the translesion synthesis pathway to cope with DNA damage by using polymerases like DNA Polymerase eta and Blm-related helicase activities. FEN1 and APE1 hold significant roles in the base excision repair pathway working closely with other repair enzymes to preserve genomic stability. Apoptosis inhibitor pathways involve regulatory proteins like Pin1 and RUNX1 which modulate cell survival signals.
- Associated diseases and disorders
These proteins relate to cancer and Bloom's syndrome. For instance mutations in Bloom's Syndrome Protein Blm increase cancer risk due to chromosomal instability while alterations in the transcription factor RUNX1/AML1 often occur in leukemia. Cytochrome P450 2C19 has pharmacogenetic implications for drug metabolism in liver diseases. Dysfunction of DNA Polymerase beta or iota links to repair deficiencies seen in tumorigenesis. These proteins through their interactions and dysfunctions highlight their significance in understanding and addressing these conditions.
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1 product image
Chemical Structure - Aurintricarboxylic acid (ATA), Apoptosis inhibitor (ab141027)
2D chemical structure image of ab141027, Aurintricarboxylic acid (ATA), Apoptosis inhibitor
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