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AB273623

AZ-20

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MW 412.5 Da. Potent and selective ATR kinase inhibitor (IC50 = 5 nM in vitro; IC50 = 50 nM in carcinoma cell lines). Selective versus mTOR (8-fold). Displayed selectivity versus a panel of 442 kinases.Inhibits LoVo colorectal adenocarcinoma tumor cell growth.
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Chemical Structure - AZ-20 (AB273623)
  • Chemical Structure

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Chemical Structure - AZ-20 (AB273623)

Chemical structure of AZ-20, 1233339-22-4

Key facts

CAS number

1233339-22-4

Form

Solid

form

Molecular weight

412.5 Da

Molecular formula

C<sub>2</sub><sub>1</sub>H<sub>2</sub><sub>4</sub>N<sub>4</sub>O<sub>3</sub>S

PubChem

46244454

Nature

Synthetic

Solubility

Soluble in DMSO (up to 20 mg/ml). Solutions in DMSO may be stored at -20°C for up to 1 month.

Biochemical name

4-[4-(1-methanesulfonylcyclopropyl)-6-[(3R)-3-methylmorpholin-4-yl]pyrimidin-2-yl]-1H-indole

Biological description

Potent and selective ATR kinase inhibitor (IC50 = 5 nM in vitro; IC50 = 50 nM in carcinoma cell lines). Selective versus mTOR (8-fold). Displayed selectivity versus a panel of 442 kinases.Inhibits LoVo colorectal adenocarcinoma tumor cell growth.

Canonical smiles

CC1COCCN1C2=NC(=NC(=C2)C3(CC3)S(=O)(=O)C)C4=C5C=CNC5=CC=C4

Isomeric smiles

C[C@@H]1COCCN1C2=NC(=NC(=C2)C3(CC3)S(=O)(=O)C)C4=C5C=CNC5=CC=C4

InChi

InChI=1S/C21H24N4O3S/c1-14-13-28-11-10-25(14)19-12-18(21(7-8-21)29(2,26)27)23-20(24-19)16-4-3-5-17-15(16)6-9-22-17/h3-6,9,12,14,22H,7-8,10-11,13H2,1-2H3/t14-/m1/s1

InChiKey

SCGCBAAYLFTIJU-CQSZACIVSA-N

IUPAC Name

(3R)-4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-3-methylmorpholine

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Biochemicals

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Biochemicals

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Chemical Structure - KU-60019, ATM kinase inhibitor (AB144817)

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Biochemicals

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Product details

Solutions in DMSO may be stored at -20° for up to 1 month.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Refer to SDS for further information.

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Product protocols

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