MW 173.13 g/mol, Purity >98%.
Serine derivative diazo compound with antibiotic, antifungal and antineoplastic properties. Structural analog of glutamine which competes with glutamine in binding to enzymes involved in purine biosynthesis. Inhibits the glutamine-dependent amidotransferases FGAM synthetase and glucosamine-6-phosphate isomerase. Inhibits the rate-limiting step of the hexosamine biosynthesis pathway (HBP) and irreversibly inhibits GGT1 (gamma-Glutamyltranspeptidase). Downregulates the expression of VCAM-1 and ICAM-1 in response to TNF-α. Protects against hyperglycemic endothelial damage through its antioxidant effect independently of inhibiting HBP pathway.
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- Pathology, research and practice 215:1526812019Glutamine-fructose-6-phosphate transaminase 2 (GFPT2) promotes the EMT of serous ovarian cancer by activating the hexosamine biosynthetic pathway to increase the nuclear location of β-catenin.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLin Zhou et. al.PubMed 31685298
Key facts
- CAS number
- 115-02-6
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 173.13 g/mol
- Nature
- Synthetic
Recommended products
MW 173.13 g/mol, Purity >98%.
Serine derivative diazo compound with antibiotic, antifungal and antineoplastic properties. Structural analog of glutamine which competes with glutamine in binding to enzymes involved in purine biosynthesis. Inhibits the glutamine-dependent amidotransferases FGAM synthetase and glucosamine-6-phosphate isomerase. Inhibits the rate-limiting step of the hexosamine biosynthesis pathway (HBP) and irreversibly inhibits GGT1 (gamma-Glutamyltranspeptidase). Downregulates the expression of VCAM-1 and ICAM-1 in response to TNF-α. Protects against hyperglycemic endothelial damage through its antioxidant effect independently of inhibiting HBP pathway.
Key facts
- CAS number
- 115-02-6
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 173.13 g/mol
- Nature
- Synthetic
- Solubility
Soluble in water.
- Biological description
Serine derivative diazo compound with antibiotic, antifungal and antineoplastic properties. Structural analog of glutamine which competes with glutamine in binding to enzymes involved in purine biosynthesis. Inhibits the glutamine-dependent amidotransferases FGAM synthetase and glucosamine-6-phosphate isomerase. Inhibits the rate-limiting step of the hexosamine biosynthesis pathway (HBP) and irreversibly inhibits GGT1 (gamma-Glutamyltranspeptidase). Downregulates the expression of VCAM-1 and ICAM-1 in response to TNF-α. Protects against hyperglycemic endothelial damage through its antioxidant effect independently of inhibiting HBP pathway.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- The product can be stored for up to 12 months
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Chemical Structure - Azaserine, serine derivative diazo compound (ab145895)
2D chemical structure image of ab145895, Azaserine, serine derivative diazo compound
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