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AB145895

Azaserine, serine derivative diazo compound

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(1 Publication)

MW 173.13 g/mol, Purity >98%. Serine derivative diazo compound with antibiotic, antifungal and antineoplastic properties. Structural analog of glutamine which competes with glutamine in binding to enzymes involved in purine biosynthesis. Inhibits the glutamine-dependent amidotransferases FGAM synthetase and glucosamine-6-phosphate isomerase. Inhibits the rate-limiting step of the hexosamine biosynthesis pathway (HBP) and irreversibly inhibits GGT1 (gamma-Glutamyltranspeptidase). Downregulates the expression of VCAM-1 and ICAM-1 in response to TNF-α. Protects against hyperglycemic endothelial damage through its antioxidant effect independently of inhibiting HBP pathway.
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Chemical Structure - Azaserine, serine derivative diazo compound (AB145895)
  • Chemical Structure

Lab

Chemical Structure - Azaserine, serine derivative diazo compound (AB145895)

2D chemical structure image of ab145895, Azaserine, serine derivative diazo compound

Key facts

CAS number

115-02-6

Purity

>98%

Form

Solid

form

Molecular weight

173.13 g/mol

Nature

Synthetic

Solubility

Soluble in water

Biological description

Serine derivative diazo compound with antibiotic, antifungal and antineoplastic properties. Structural analog of glutamine which competes with glutamine in binding to enzymes involved in purine biosynthesis. Inhibits the glutamine-dependent amidotransferases FGAM synthetase and glucosamine-6-phosphate isomerase. Inhibits the rate-limiting step of the hexosamine biosynthesis pathway (HBP) and irreversibly inhibits GGT1 (gamma-Glutamyltranspeptidase). Downregulates the expression of VCAM-1 and ICAM-1 in response to TNF-α. Protects against hyperglycemic endothelial damage through its antioxidant effect independently of inhibiting HBP pathway.

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Pathology, research and practice 215:152681 PubMed31685298

2019

Glutamine-fructose-6-phosphate transaminase 2 (GFPT2) promotes the EMT of serous ovarian cancer by activating the hexosamine biosynthetic pathway to increase the nuclear location of β-catenin.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Zhou,Mu Luo,Li-Juan Cheng,Ruo-Nan Li,Bin Liu,Hua Linghu
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