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AB142049

AZD1152-HQPA, Aurora B kinase inhibitor

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(1 Publication)

MW 507.6 Da, Purity >99%. Potent, selective Aurora B kinase inhibitor (IC50 = 0.37 nM). Induces apoptosis in vitro. Antitumor agent. Cell-permeable. Active in vitro and in vivo.
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Chemical Structure - AZD1152-HQPA, Aurora B kinase inhibitor (AB142049)
  • Chemical Structure

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Chemical Structure - AZD1152-HQPA, Aurora B kinase inhibitor (AB142049)

2D chemical structure image of ab142049, AZD1152-HQPA, Aurora B kinase inhibitor

Key facts

CAS number

722544-51-6

Purity

>99%

Form

Solid

form

Molecular weight

507.6 Da

Molecular formula

C<sub>2</sub><sub>6</sub>H<sub>3</sub><sub>0</sub>FN<sub>7</sub>O<sub>3</sub>

PubChem

16007391

Nature

Synthetic

Solubility

Soluble in DMSO to 25 mM

Biochemical name

Azd-1152hqpa

Biological description

Potent, selective Aurora B kinase inhibitor (IC50 = 0.37 nM). Induces apoptosis in vitro. Antitumor agent. Cell-permeable. Active in vitro and in vivo.

Canonical smiles

CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCO

InChi

InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33)

InChiKey

QYZOGCMHVIGURT-UHFFFAOYSA-N

IUPAC Name

2-[3-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]quinazolin-4-yl]amino]-1H-pyrazol-5-yl]-N-(3-fluorophenyl)acetamide

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 1583 Aurora Kinase B Inhibitor (AZD1152-HQPA). 1583-25 is the same size as the 25 mg size of ab142049.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell division 15:11 PubMed32973917

2020

XMU-MP-1 induces growth arrest in a model human mini-organ and antagonises cell cycle-dependent paclitaxel cytotoxicity.

Applications

Unspecified application

Species

Unspecified reactive species

Ellen Mitchell,Charlotte E L Mellor,Talveen S Purba
View all publications
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