AZD1480

Key facts

CAS number

935666-88-9

Purity

>98%

Form

Solid

form

Molecular weight

348.76 Da

Molecular formula

C₁₄H₁₄ClFN₈

PubChem

16659841

Nature

Synthetic

Solubility

?93.8 mg/mL in DMSO

?4.57 mg/mL in EtOH with ultrasonic and warming

Insoluble in H2O

Biochemical name

Azd-1480

Biological description

Novel, potent and selective small-molecule JAK2 inhibitor (IC₅₀ < 3 nM). It can effectively inhibit tumor angiogenesis and metastasis mediated by STAT3 in stromal cells as well as tumor cells. Also demonstrates >50-fold selectivity for JAK2 over JAK3.

Canonical smiles

CC1=CC(=NN1)NC2=NC(=NC=C2Cl)NC(C)C3=NC=C(C=N3)F

Isomeric smiles

CC1=CC(=NN1)NC2=NC(=NC=C2Cl)N[C@@H](C)C3=NC=C(C=N3)F

InChi

InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1

InChiKey

PDOQBOJDRPLBQU-QMMMGPOBSA-N

IUPAC Name

5-chloro-2-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-4-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine