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AB216311

AZD4547, FGFR inhibitor

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(3 Publications)

MW 463.6 Da, Purity >98%. Novel, selective inhibitor of the FGFR1, 2, and 3 tyrosine kinases. Binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways, thus resulting in the inhibition of tumor cell proliferation and tumor cell death.
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Chemical Structure - AZD4547, FGFR inhibitor (AB216311)
  • Chemical Structure

Lab

Chemical Structure - AZD4547, FGFR inhibitor (AB216311)

2D chemical structure image of ab216311, AZD4547, FGFR inhibitor

Key facts

CAS number

1035270-39-3

Purity

>98%

Form

Solid

form

Molecular weight

463.6 Da

Molecular formula

C<sub>2</sub><sub>6</sub>H<sub>3</sub><sub>3</sub>N<sub>5</sub>O<sub>3</sub>

PubChem

51039095

Nature

Synthetic

Solubility

DMSO (>80 mg/ml)

Biochemical name

Azd-4547

Biological description

Novel, selective inhibitor of the FGFR1, 2, and 3 tyrosine kinases. Binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways, thus resulting in the inhibition of tumor cell proliferation and tumor cell death.

Canonical smiles

CC1CN(CC(N1)C)C2=CC=C(C=C2)C(=O)NC3=NNC(=C3)CCC4=CC(=CC(=C4)OC)OC

Isomeric smiles

C[C@@H]1CN(C[C@@H](N1)C)C2=CC=C(C=C2)C(=O)NC3=NNC(=C3)CCC4=CC(=CC(=C4)OC)OC

InChi

InChI=1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21(29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8,15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+

InChiKey

VRQMAABPASPXMW-HDICACEKSA-N

IUPAC Name

N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3S,5R)-3,5-dimethylpiperazin-1-yl]benzamide

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Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB10646

Anti-FGFR1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGFR1 antibody (AB10646)

  • 4
  • 4
Biochemicals

AB146602

SU-5402 (DMSO solution), VEGFR and FGFR inhibitor

Chemical Structure - SU-5402 (DMSO solution), VEGFR and FGFR inhibitor (AB146602)

  • 0
  • 0
Primary Antibodies

AB18258

Anti-PSD95 antibody - Synaptic Marker

BOND RX™ Validated|Lab Essentials

Western blot - Anti-PSD95 antibody - Synaptic Marker (AB18258)

  • 5
  • 40
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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 9403 AZD-4547. 9403-25 is the same size as the 25 mg size of ab216311.
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|Store under desiccating conditions
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

VEGF Receptor 2 also known as KDR or Flk-1 along with FGFR1 FGFR2 FGFR3 and FGFR4 are important targets in cellular signaling pathways. VEGFR2 with a molecular weight of approximately 150 kDa is a tyrosine kinase receptor prominently expressed in vascular endothelial cells. FGFRs share similar functional motifs and are expressed widely with variations in expression in tissue types like mesenchyme and oligodendrocytes. AZD-4547 is known as an FGFR inhibitor specifically targeting these receptors.
Biological function summary

VEGFR2 and FGFRs play roles in angiogenesis and tissue development. VEGFR2 mediates endothelial cell proliferation migration and new blood vessel formation. FGFRs form a complex with fibroblast growth factors and mediate signaling that controls cell differentiation proliferation and survival. Both VEGFR2 and FGFRs interact in ligand-receptor complexes to induce downstream signaling cascades for tissue vascular and development processes.

Pathways

VEGFR2 and FGFRs are integral to the MAPK and PI3K-Akt pathways. These pathways affect cellular responses such as growth and survival. VEGFR2's signaling interplays with proteins like PLCγ and Src to promote angiogenesis. FGFRs interact within the FGF signaling pathway connecting with proteins like SOS and Ras which regulate gene expression related to cell growth and differentiation.

VEGFR2 and FGFRs link to cancer and developmental syndromes. VEGFR2 is associated with pathological angiogenesis in various cancers and its overexpression can lead to tumor growth. Mutations in FGFRs cause disorders like skeletal dysplasia. Both VEGFR2 and FGFRs connect with other proteins such as PDGFR and EGFR influencing disease progression through altered signaling.
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Product protocols

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Molecular & cellular proteomics : MCP 22:100655 PubMed37793502

2023

Impact of Bmal1 Rescue and Time-Restricted Feeding on Liver and Muscle Proteomes During the Active Phase in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jacob G Smith,Jeffrey Molendijk,Ronnie Blazev,Wan Hsi Chen,Qing Zhang,Christopher Litwin,Valentina M Zinna,Patrick-Simon Welz,Salvador Aznar Benitah,Carolina M Greco,Paolo Sassone-Corsi,Pura Muñoz-Cánoves,Benjamin L Parker,Kevin B Koronowski

Hepatology communications 6:1574-1588 PubMed35271760

2022

FGF1 Signaling Modulates Biliary Injury and Liver Fibrosis in the Mdr2 Mouse Model of Primary Sclerosing Cholangitis.

Applications

Unspecified application

Species

Unspecified reactive species

April O'Brien,Tianhao Zhou,Tori White,Abigail Medford,Lixian Chen,Konstantina Kyritsi,Nan Wu,Jonathan Childs,Danaleigh Stiles,Ludovica Ceci,Sanjukta Chakraborty,Burcin Ekser,Leonardo Baiocchi,Guido Carpino,Eugenio Gaudio,Chaodong Wu,Lindsey Kennedy,Heather Francis,Gianfranco Alpini,Shannon Glaser

International journal of molecular medicine 36:442-8 PubMed26082290

2015

Recruitment of mesenchymal stem cells by stromal cell-derived factor 1α in pulp cells from deciduous teeth.

Applications

Unspecified application

Species

Unspecified reactive species

Yuki Akazawa,Tomokazu Hasegawa,Yoshitaka Yoshimura,Naoyuki Chosa,Takeyoshi Asakawa,Kimiko Ueda,Asuna Sugimoto,Takamasa Kitamura,Hiroshi Nakagawa,Akira Ishisaki,Tsutomu Iwamoto
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