AZD6244, MEK1/2 inhibitor

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MW 457.7 Da, Purity >99%. Potent, selective, non-ATP competitive MEK1/2 inhibitor (IC₅₀ MEK1 = 14 nM). Also inhibits ERK1/2 phosphorylation.

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AAK1_HUMAN, AIS, ANDR_HUMAN, AP2 associated kinase 1, AP2-associated protein kinase 1, AR, AR8, Adaptor-associated kinase 1, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor, testicular feminization, spinal and bulbar muscular atrophy, Kennedy disease), Atherosclerosis, susceptibility to, included, Avian erythroblastic leukemia viral (v erb b) oncogene homolog, BIKe, BMP-2-inducible protein kinase, BMP2 inducible kinase, BMP2K, BMP2K_HUMAN, Bike kinase, CFC syndrome, CFC4, CK II, CK II alpha', CK2A2, CSK22_HUMAN, Cardiofaciocutaneous syndrome, Casein kinase 2 alpha prime polypeptide, Casein kinase II alpha' chain, Casein kinase II subunit alpha', Cell growth inhibiting protein 40, Cell proliferation inducing protein 61, DHTR, DKFZp434K0614, DKFZp434P0116, DKFZp686F03202, DKFZp686K16132, DKFZp686N23123, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), Dual specificity mitogen-activated protein kinase kinase 1, Dual specificity mitogen-activated protein kinase kinase 2, EGFR_HUMAN, ER, ER-alpha, ER-beta, ERBB, ERBB1, ERK activator kinase 1, ERK activator kinase 2, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESRA, ESTR B, Epidermal growth factor receptor, Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog), Epidermal growth factor receptor (erythroblastic leukemia viral (v erb b) oncogene homolog avian), Era, Erb, Erb2, Errp, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta 4, Estrogen resistance, included, FLJ23712, FLJ25931, FLJ26075, FLJ31060, FLJ42882, FLJ43934, FLJ45252, HDL cholesterol, augmented response of, to hormone replacement, included, HER1, HRIHFB2017, HUMARA, HYSP1, IMD42, KD, KIAA1048, Kennedy disease (KD), MAP kinase kinase 1, MAP kinase kinase 2, MAP kinase/Erk kinase 1, MAP2K1, MAP2K2, MAPK / ERK kinase 2, MAPK/ERK kinase 1, MAPKK 1, MAPKK 2, MEK 1, MEK 2, MEKK 1, MGC129539, MGC138170, MGC164568, MGC164570, MKK 1, MKK 2, MP2K1_HUMAN, MP2K2_HUMAN, Microtubule associated protein kinase kinase 2, Mitogen Activated Protein Kinase Kinase 1, Mitogen activated protein kinase kinase 2, Mitogen activated protein kinase kinase 2 p45, Myocardial infarction, susceptibility to, included, NISBD2, NR1F3, NR3A1, NR3A2, NR3C4, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), OTTHUMP00000017718, OTTHUMP00000017719, OTTHUMP00000165826, OTTHUMP00000165827, Oncogen ERBB, PIG61, PRKMK 1, PRKMK 2, Protein kinase mitogen activated kinase 1 (MAP kinase kinase 1), Proto-oncogene c-ErbB-1, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-related orphan receptor C, RNESTROR, RORG_HUMAN, RZR GAMMA, RZRG, Receptor tyrosine-protein kinase ErbB-1, Retinoic acid binding receptor gamma, Retinoid-related orphan receptor-gamma, Rorc, SA7, SBMA, SMAX1, Species antigen 7, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), TFM, TOR, Testicular Feminization (TFM), Urogastrone, Wa5, androgen receptor splice variant 4b, erb-b2 receptor tyrosine kinase 1, mENA, protein kinase mitogen-activated kinase 1, v-erb-b Avian erythroblastic leukemia viral oncogen homolog, wa2