MW 461.23 Da, Purity >98%. Achieve your results faster with highly validated, pure and trusted compounds.
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CFC syndrome, CFC4, Cardiofaciocutaneous syndrome, Dual specificity mitogen-activated protein kinase kinase 1, Dual specificity mitogen-activated protein kinase kinase 2, Dual specificity mitogen-activated protein kinase kinase 5, E2AK1_HUMAN, EC 2.7.11.1, EC 2.7.12.2, EIF2AK1, ERK activator kinase 1, ERK activator kinase 2, Eukaryotic translation initiation factor 2-alpha kinase 1, FLJ26075, HCR, HRI, Heme regulated initiation factor 2 alpha kinase, Heme regulated repressor, Heme sensitive initiation factor 2a kinase, Heme-controlled repressor, Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase, Heme-regulated inhibitor, Hemin-sensitive initiation factor 2-alpha kinase, HsT17454, KIAA1369, MAP kinase kinase 1, MAP kinase kinase 2, MAP kinase kinase 5, MAP kinase kinase MEK5b, MAP kinase/Erk kinase 1, MAP2K1, MAP2K2, MAP2K5, MAPK / ERK kinase 2, MAPK/ERK kinase 1, MAPK/ERK kinase 5, MAPKK 1, MAPKK 2, MAPKK 5, MEK 1, MEK 2, MEKK 1, MKK 1, MKK 2, MKK5, MP2K1_HUMAN, MP2K2_HUMAN, MP2K5_HUMAN, Microtubule associated protein kinase kinase 2, Mitogen Activated Protein Kinase Kinase 1, Mitogen activated protein kinase kinase 2, Mitogen activated protein kinase kinase 2 p45, OTTHUMP00000165826, OTTHUMP00000165827, PRKMK 1, PRKMK 2, PRKMK5, PRO1362, Protein kinase mitogen activated kinase 1 (MAP kinase kinase 1), Protein kinase, mitogen-activated, kinase 5, SAPKK5, SKK5, mitogen-activated protein kinase kinase 5, protein kinase mitogen-activated kinase 1
Product details
This product is manufactured by BioVision, an Abcam company and was previously called B1693 AZD8330. B1693-5 is the same size as the 5 mg size of ab235504.
Protect from air and light.
Properties and storage information
Shipped at conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
MEK proteins are key components in cell signal transduction influencing numerous cellular processes such as proliferation differentiation and survival. MEK1 and MEK2 are closely related and often function together in signaling cascades while MEK5 activates ERK5 with distinct effects. Meanwhile HRI exerts control over protein translation by phosphorylating the eukaryotic initiation factor 2 alpha subunit (eIF2α) in response to stress conditions like iron deficiency. This inhibition prevents overproduction of globin proteins when heme is insufficient therefore balancing hemoglobin synthesis.
Pathways
MEK1 and MEK2 are integral parts of the MAPK/ERK pathway which plays an important role in growth factor signaling. They transmit signals from activated Ras protein eventually leading to ERK1/2 activation which influences gene expression. MEK1/2 inhibitors like AZD8330 can reduce downstream signaling which is useful in studying pathway dynamics. MEK5 participates in the MEK5-ERK5 pathway which sometimes shows cross-talk with MAPK/ERK signaling. HRI however is involved in pathways related to stress responses and does not overlap with these MAPK pathways.
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